Composite traditional Chinese medicine lozenge as well as preparation method and application thereof
A technology of compound traditional Chinese medicine and traditional Chinese medicine, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and medical formulas, and can solve the problems of inconvenient carrying, storage, and taking of mixtures, easy drug resistance, and poor overall effect. Achieve the effect of being easy to carry and take, avoiding drug resistance, and improving taste
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Embodiment 1
[0035] Example 1 Effect Test on Rat Acute Pharyngitis Model
[0036] 1. Test material
[0037] Samples: Viola dicarpa extract and Dandelion extract prepared by the process described in Best Example 11 were used as test samples, and a uniform suspension was prepared with 0.5% sodium carboxymethylcellulose solution. Positive control drug: Golden Throat Lozenges.
[0038] Animals and grouping: Wistar rats were divided into normal control group, model control group, positive control group and Example 1 group. Pharyngeal spray administration, the dosage of Example 1 group is 76 mg / kg / d of viola extract + 38 mg / kg / d of dandelion extract, and the dosage of the positive control group is 926 mg / kg / d.
[0039] Instruments: electronic scales, ultra-clean bench, magnetic stirrer.
[0040] 2. Test method
[0041] After the rat was fixed with a spatula, 15% ammonia solution was sprayed in the throat of the rat; 0.5ml was sprayed each time, once a day at 9:00, 13:00, and 16:00, for 4 conse...
Embodiment 2
[0055] Example 2 Effect Test on Rabbit Chronic Pharyngitis Model
[0056] 1. Test material
[0057] Samples: Viola dicarpa extract and Dandelion extract prepared by the process described in Best Example 11 were used as test samples, and a uniform suspension was prepared with 0.5% sodium carboxymethylcellulose solution. Positive control drug: Erding Granules.
[0058] Animals and grouping: Japanese big-eared white rabbits, divided into normal control group, model control group, positive control group and Example 1. Pharyngeal spray administration, the dosage of the embodiment 1 group is viola chinensis extract 43.4mg / kg / d+dandelion extract 21.7mg / kg / d, and the dosage of the positive control group is 2657.3mg / kg / d .
[0059] Instruments: electronic scales, ultra-clean bench, magnetic stirrer.
[0060] 2. Test method
[0061] Modeling was made according to Peng's modeling method, that is, after the tongue was fixed with a tongue depressor, 2.5% ammonia solution was sprayed o...
Embodiment 3
[0072] The preparation of embodiment 3 compound Chinese medicine buccal tablets
[0073] 1) Preparation of the extract of Viola chinensis: take the medicinal material of Viola chinensis, add 14 times and 10 times the amount of 80% ethanol, heat and reflux extraction twice, each time for 1 hour, filter, combine the filtrates, and recover the ethanol under reduced pressure And concentrated to the amount of medicinal materials, centrifuged, the centrifugate was added to the treated HPD-826 macroporous adsorption resin column at a flow rate of 0.5BV / h, first eluted with 3BV water at a flow rate of 3BV / h, and then sequentially washed with 2BV 30 % and 2BV 60% ethanol were eluted at a flow rate of 2BV / h, the corresponding alcohol eluent was collected, the ethanol was recovered, concentrated into a thick paste with a relative density of 1.25-1.30, and vacuum-dried at 80°C and a vacuum degree greater than 0.8Mpa. Smash, that is.
[0074] 2) Preparation of dandelion extract: Take dand...
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