59results about How to "Avoid first pass" patented technology

The invention discloses a medicinal composition containing sildenafil citrate and PD-1 type pregelatinized starch and a preparation method thereof. The medicinal preparation prepared from the medicinal composition containing the sildenafil citrate and the PD-1 type pregelatinized starch and the preparation method provided by the invention can be completely disintegrated in water at a degree of 37 DEG C within 15 to 30 seconds, and can pass through a screen in a size of 600 to 710 mu m.

The present invention discloses one kind of sodium diester alginate dripping pill and its preparation process. The sodium diester alginate dripping pill is compounded with sodium diester alginate and dripping pill matrix. The present invention has high bioavailability, high stability, convenient taking, fast disintegration and dissolving, high leaching degree, fast medicine releasing, fast acting, simple production process, low cost and other features.

A dripping pill of dandelion herb for treating upper respiratory tract infection, sore, furuncle, enteritis, etc is prepared from dandelion herb. Its preparing process is also disclosed.

The invention provides medicinal dripping pills and process for preparation, wherein the pills have the functions of set one's mind at ease and relaxing tendon and vein, and can be used for treating breakdown between the heart and the kidney, insomnia and cardiopalmus, the medicament is prepared from Chinese medicinal materials of goldthread root and Cinnamomum cassia through extracting, and mixing extractive with dripping pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying.

A Chinese medicine in the form of plaster for treating tumor is prepared from 34 Chinese-medicinal materials including cyprus tuber, zedoary, Chinese angelica root, myrrh, etc. Its preparing process is also disclosed.

The invention discloses a life nourishing and health preservation device for massaging acupuncture points of a human body, and relates to a life nourishing massager, in particular to a massage device for massaging a seabed acupuncture point (perineum acupuncture point). The life nourishing massager comprises a body, wherein the body is composed of a zinc shell and a zinc ball, a motor is arranged in the zinc shell, a vibratory hammer is arranged on a cam, and the zinc ball is arranged at one end of a flexible pipe. A use method of the life nourishing massager includes: placing the zinc ball in a rectum, and exactly pressing the external zinc shell against the seabed acupuncture point. After a power source is started, the motor drives the vibratory hammer to shake, and the vibratory hammer shakes and hits the seabed acupuncture point so as to massage the seabed acupuncture point, and simultaneously the zinc ball implanted in the rectum can perform holographic massage on the rectum. The life nourishing massager is simple in structure and ingenious in design. A user can use the life nourishing massager when the user walks, sits and lies, and seabed acupuncture point massage and the holographic massage can be simultaneously performed, and then the massage and zinc supplementing can be simultaneously performed. The life nourishing massager is an ideal traditional Chinese medicine health preservation device, and solves problems existing in a common finger pressing method.

A dripping pill of bisoprolol fumarate for treating primary hypertension and angina pectoris is prepared from bisoprolol fumarate and the matrix of dripping pill. Its preparing process is also disclosed.

A dripping pill of cinnarizine for treating cerebrovascular obstacle, cerebral thrombus and cerebral arteriosclerosis is prepared from the cinnarizine and the matrix of dripping pill. Its preparing process is also disclosed.

The invention relates to a medicinal dripping pill for treating intestine diseases and its preparation, wherein the medicament possesses functions of reducing fever, removing dampness, regulating flow of qi and relieving pain, and the medicament is prepared from Chinese medicinal materials of banksia rose, evodia rutaecarpa benth through steps of extracting, palletizing berberine hydrochloride into fines, and mixing with drop pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying.

The invention provides compound Cortex Phellodendri gel for treating child eczema and a preparation method. The compound Cortex Phellodendri gel for treating child eczema consists of the following raw herbal medicines in parts by weight: 70-90 parts of Fructus Forsythiae, 35-45 parts of Cortex Phellodendri, 35-45 parts of honeysuckle, 35-45 parts of dandelion, 2.1-2.7 parts of Scolopendra, 1-6 parts of carbomer, 5-15 parts of Transcutol P, 2-5 parts of triethanolamine, 10-30 parts of glycerol and 0.1-0.5 part of potassium sorbate. By the compound Cortex Phellodendri gel, the shortcomings that the residence time of compound Cortex Phellodendri liquid liniment on wound is short, and the wound needs to be covered with gauze can be overcome to a great extent; compared with other domestic and international like products, the compound Cortex Phellodendri gel has considerable resource advantages and technical advantages; and used Chinese herbal medicines are common medicinal materials, auxiliary materials are common pharmaceutic adjuvants, and the supply quality can be guaranteed. The traditional Chinese medicine extracting technology is mainly used, and is organically combined to an alcohol precipitation and water precipitation separation technology, a gel preparation process and the like, effective ingredients of traditional Chinese medicines and the pharmaceutic adjuvants are combined organically, and the efficacy is played fully. The compound Cortex Phellodendri gel for treating child eczema has considerable social benefit and economic benefit.

The present invention discloses a medicine fexofenadine hydrochloride dripping pills preparation for effectively curing seasonal allergic rhinitis and chronic idiopathic urticaria and its preparation process. It is made up by using fexofenadine hydrochloride and matrix for making dripping pills.

The invention relates to a medicinal dripping pill of spatholobus stem and its preparation, wherein the medicament possesses functions of enriching blood, promoting blood circulation, relaxing tendon and vein, and can be used for treating hyphemia, asthenia, abnormal menstruation, dysmenorrhea, sallow complexion, anesthesia, paralysis and rheumatalgia. The medicament is prepared from Chinese medicinal herb of spatholobus stem through extracting and mixing extractive with dripping pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying. The medicament also has the advantages of quicker disintegration and dissolution, higher dissolution, quick-speed medicine release, quick-speed effect, simple process for manufacturing, and low cost.

The present invention discloses one kind of diltiazem hydrochloride dripping pill and its preparation process. The diltiazem hydrochloride dripping pill is compounded with diltiazem hydrochloride and dripping pill matrix. The present invention has high bioavailability, high stability, convenient taking, fast disintegration and dissolving, high leaching degree, fast medicine releasing, fast acting, simple production process, low cost and other features.

The invention belongs to the field of medicinal preparations. Nimodipine serving as a clinical cerebrovascular medicament is applied for years; however, the nimodipine has the defects of poor water solubility, obvious first pass effect and the like due to the physicochemical property of the nimodipine, which directly influence clinical medicinal effect. The invention provides nimodipine oral fast dissolving tablets and a preparation method thereof. The preparation method comprises the following steps of: preparing a nimodipine solid dispersion with high water solubility from a nimodipine raw material and a hydrophilic carrier by a spray drying process; mixing the solid dispersion and suitable auxiliary materials; and preparing the oral fast dissolving tablets by a direct powder compression method. The preparation process is simple and industrial production is easy to realize. The prepared nimodipine oral fast dissolving tablets can be administrated without water. After being administrated, the nimodipine oral fast dissolving tablets are rapidly dissolved and absorbed in an oral cavity in 30 seconds so as to avoid the first pass effect of the gastrointestinal tract, greatly improve the dissolution rate of the medicament and improve the bioavailability of the medicament.

A dripping pill of green chiretta for treating cold, tonsillitis, enteritis and urethritis is prepared from green chiretta and matrix. Its preparing process is also disclosed.

The invention belongs to the field of pharmaceutical medicine, specifically relates to a drug lamp stand leaves pills and its preparation method which has effect of relieving cough, removing the phlegm and anti-inflammatory and applies to chronic bronchitis and pertussis. The invention use extracts from the herbal material lamp stand leaves and is prepared by lamp stand leaves extract and pill base. The bioavailability of the invention is high, the drug stability is good, drug size is small, taking and carry is easy, in particular is help for patient swallow medication who has swallowing difficulty. It has the characteristics of rapid collapse and dissolution, high dissolution degree, rapid releasing medication, rapid effect and so on, and production technology is simple and cost is low.

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly discloses an oral traditional Chinese medicine film agent and a method for preparing the same. The oral traditional Chinese medicine film agent mainly comprises, by weight, 5-70 parts of raw materials and 30-100 parts of excipients. The oral traditional Chinese medicine film agent prepared bythe aid of the method is a square laminar film with the area of 1 cm<2>. The oral traditional Chinese medicine film agent and the method have the advantages that the oral traditional Chinese medicinefilm agent can be attached to the surfaces of mucosas, accordingly, effects of protecting the mucosas can be realized, site-specific delivery can be carried out on medicines, and curative effects canbe improved.

A Chinese medicine 'Houshuning dripping pill' for treating pharyngolaryngitis, acute tonsillitis, polyp on vocal fold, neck cancer, etc is prepared from oldenlandia, green chiretta and screwtree root. Its preparing process is also disclosed.

A dripping pill of cottonrose hibiscus for treating influenza is prepared from cottonrose hibiscus. Its preparing process is also disclosed.

The invention discloses a cataplasm for treating gout and a preparation method thereof. The cataplasm comprises a principal agent, a base, a transdermal enhancer, water and a medical non-woven fabric,wherein the principal agent comprises a medicinal extract, the medicinal extract comprises phellodendron bark, rhizoma atractylodis, caulis trachelospermi, dahurian angelica root, medicinal cyathularoot and danshen root, the base comprises sodium polyacrylate, PHV, PEG (200) and glycerol, and the transdermal enhancer is azone or menthol. The cataplasm disclosed by the invention is applied to acute inflammation attacks of gout patients, and has very remarkable effects on reducing the uric acid level of the gout patients and relieving joint reddish swelling and pain.

A dripping pill of pravastatin sodium for treating hyperlipemia is prepared from the pravastatin sodium and the matrix of dripping pill. Its preparing process is also disclosed.

The present invention discloses one kind of piroxicam dripping pill and its preparation process. The piroxicam dripping pill is compounded with piroxicam and dripping pill matrix. The present invention has high bioavailability, high stability, convenient taking, fast disintegration and dissolving, high leaching degree, fast medicine releasing, fast acting, simple production process, low cost and other features.

The slimming toothpaste consists of plant extract in 5-8 wt% and toothpaste cream in 92-95 wt%. The plant extract is extracted from lotus leaf, gamboge fruit, Asiatic centella, aloe, mulberry, oolong, astragalus root and wolfberry fruit. The toothpaste cream consists of Carbogel, xanthan gum, CMC, saccharin sodium, sorbic alcohol, glycerin, sodium dodecyl sulfate, polyethylene glycol, polyester, silica, titania, preservative, essence and water. The present invention has functions of cleaning teeth and reducing weight. It reaches the function of reducing weight by means of the synergistic effects of promoting fat burning, reducing absorption to fat, inhibiting the conversion of carbohydrate to fat, raising metabolism level, promoting urination, nourishing Yin and invigorating Qi.

A dripping pill of green chiretta for treating cold, sore throat, bronchitis and tonsillitis is prepared from green chiretta. Its preparing process is also disclosed.

The invention discloses a composite traditional Chinese medicine lozenge which has effects of clearing away heat and toxic materials and relieving swelling and stopping pain, as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicine preparations. The composite traditional Chinese medicine lozenge consists of the following components in percentage by weight: 4-10% of a Chinese violet extract, 1-5% of a dandelion extract and 85-95% of medicinal auxiliary materials. The invention further discloses a method for preparing the composite traditional Chinese medicine lozenge. The method comprises main processes of preparing the Chinese violet extract, preparing the dandelion extract and preparing the composite traditional Chinese medicine lozenge. In addition, the invention further discloses application of the composite traditional Chinese medicine lozenge in preparing a medicine for treating pharyngitis. Compared with a preparation for treating pharyngitis in the market, the composite traditional Chinese medicine lozenge disclosed by the invention is concise and special in medicinal effect, can treat both symptoms and root causes and is good in specificity as the medicine is retained at focuses of throats for a long time and the medicinal effects can be brought into play rapidly and continuously; meanwhile, by adopting the oral lozenge, the first pass effect of livers can be avoided, and the bioavailability can be high.

The invention provides a Chinese medicinal tablet for purging the pathogenic fire, which comprises (based on 1000 tablets in g), rhubarb horsetails 120-200, pearl 80-150, natural indigo 150-190, water melon frost 80-150, cow-bezoar 2-50, borneol 10-50. Its preparing process is also disclosed in the invention.

A dripping pill of senecio for treating acute conjunctitis, acute pharyngolaryngitis, acute tonsillitis, acute enteritis, acute bacterial dycentery, upper respiratory tract inflammation, etc is prepared from senecio. Its preparing process is also disclosed.

The invention discloses an oral instant microcapsule tablet prepared from rhizoma chuanxiong volatile oil and a preparation method of the oral instant microcapsule tablet. The preparation method comprises the following steps: uniformly mixing a capsule material (ethyl cellulose) with a solvent (ethyl acetate) to obtain a mixture, uniformly mixing the mixture with a capsule core (rhizoma chuanxiong volatile oil) so as to obtain an oil phase, and uniformly mixing an emulsifying agent (lauryl sodium sulfate) and a saturated water solution of the solvent (ethyl acetate) so as to obtain a water phase, wherein the concentration of the emulsifying agent is 0.8%-1.2%; dropwise adding the oil phase into the water phase at a stirring speed of 500rpm-600rpm so as to obtain an emulsion, and washing, so as to obtain microcapsules, wherein the mass ratio of the capsule material to the capsule core is (1.5 to 1)-(2.5 to 1), and the volume ratio of the oil phase to the water phase is (1 to 4)-(1 to 6); and (2) uniformly mixing 40%-60% of microcapsules and a disintegrating agent (3%-7% of cross-linked povidone and 8%-12% of sodium carboxymethyl starch), a filling agent (10%-30% of lactose and 8%-12% of microcrystalline cellulose) and a lubricating agent (4%-6% of micropowder silica gel), and tabletting. The prepared oral instant microcapsule tablet is short in disintegration time and high in bioavailability.

The invention discloses a uremia skin dialysis curer combining massaging and transdermal administration. The uremia skin dialysis curer consists of an extruding type massaging head driven by using a micro motor, an ultrasonic low-frequency transdermal administration curer, and Chinese and Western medicines. Friction administration through friction heat generation, ultrasonic heating and extruding impact is combined with ultrasonic vibrating cavatition administration, and Chinese and Western medicines enter human bodies through a keratoderma barrier for performing blood circulation, so that the technical problem of transdermal administration existing in the conventional uremia skin dialysis treatment is solved, transdermal administration treatment can be performed on uremia patients for whom oral taking of medicaments and medicament injection treatment are invalid, and metabolism recovery treatment can be performed by inputting mechanical energy, heat energy and chemical energy into patients with extensive whole body poison symptoms through medicament passaging. The uremia skin dialysis curer is combined with Chinese medicinal bath, blood dialysis and peritoneal dialysis, so that the skin dialysis treatment effect can be updated and enhanced, the treatment cost is lowered, and the treatment goal of controlling the pathologic change and development trends of reverse uremia is achieved.