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Herba Andrographitis dripping pills for treating cold, and its preparing method

A technology of Andrographis paniculata and dripping pills, which is applied in the direction of pill delivery, anti-infective drugs, and medical raw materials derived from angiosperm subphylum, which can solve the problems of low bioavailability, unstable quality, and long disintegration time, and achieve bioavailability High purity, good drug stability, and the effect of reducing dust pollution

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of such conventional preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset, and low bioavailability, which affect the full play of the drug effect.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Herba Andrographitis dripping pills for treating cold, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Get 2000g of Andrographis paniculata and 2000g of Mateng, add water to decoct twice, the amount of water added is 8 times for the first time, and 6 times for the second time, the decoction time is 2 hours for the first time, 1 hour for the second time, Combine the decoctions, let stand for 12 hours, filter, concentrate the filtrate to an extract with a relative density of 1.16-1.26 (60°C), add ethanol to make the alcohol content 70%, stir evenly, let stand for 24 hours, and take the supernatant Ethanol is recovered from the liquid, concentrated into an extract, and the extract is vacuum-dried to obtain an extract. Take the extract, crush it, and pass through a 100-mesh sieve. Andrographis paniculata, Maima vine extract by weight ratio: polyethylene glycol 6000 =1:2.5 ratio, add to the melted matrix (85°C), stir evenly, drop into the simethicone coolant (3°C), separate the dripping pills, absorb the coolant, and dry to obtain.

Embodiment 2

[0020] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves. Andrographis paniculata by weight, Maima vine extract: the ratio of mixed matrix=1:2 (mixed matrix is ​​polyethylene glycol 6000 : poloxamer according to 1:0.3 formula), add to the melted mixed matrix (85°C), stir evenly, drop into the simethicone coolant (3°C), separate the dropping pills, absorb the coolant , dried, that is.

Embodiment 3

[0021] Example 3: In this example, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated through the extracts of Andrographis paniculata paniculata and Maimaiteng and different matrix formulations, so as to determine the weight ratio of the extract to a single or mixed matrix.

[0022] Andrographis paniculata, Maimaiteng extracts and different matrix formulation tests (extracts are 1 part)

[0023] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0024] 2. The above results show that all the indicators of No. 4~11 experiments are good, that is, when the ratio of the extract to the matrix is ​​1:1~1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test No. 4, 6, 8, and 10, that is, the ratio...

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PUM

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Abstract

A dripping pill of green chiretta for treating cold, sore throat, bronchitis and tonsillitis is prepared from green chiretta. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Qinggan Chuanxinlian dripping pill and a preparation process thereof. Background technique [0002] Flu is a common respiratory disease caused by a variety of viruses, which can take place throughout the year. The incidence of colds does not distinguish between age, gender, occupation, and region. Many people suffer from colds every year. It is a disease that almost everyone has experienced personally. "Headache and brain fever" visits from time to time, which can make people uncomfortable and affect work and study. Seriously, it will cause complications and cause greater health hazards. Traditional Chinese medicine divides colds into three types: wind-cold, wind-heat, and summer-dampness. The clinical manifestations of wind-heat are fever, mild aversion to cold, headache, thirst, stuffy nose, thick yellow nasal mucus, sore throat, et...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K9/20A61P31/00A61P11/02A61P11/04
Inventor 陈茜滕慧丽
Owner 陈茜
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