Intestine disease treating drop pills and its preparation method

The technology of Kang Dropping Pill and Dropping Pill is applied in the field of Changkang Dropping Pill and its preparation technology, which can solve the problems of taking patients with difficulty in swallowing, low bioavailability, long disintegration time limit, etc. The effect of high bioavailability and avoidance of first-pass effect of liver and intestine

Inactive Publication Date: 2007-07-04
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of the conventional preparation technology, such oral preparations have long disintegration time, poor dissolution, slow onset, and low bioavailability, which affect the full play of the drug effect.
At the same time, it is easy to split, change color, absorb moisture, crack, etc. during storage, and the quality is unstable
It is also not suitable for patients with swallowing difficulties

Method used

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  • Intestine disease treating drop pills and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Get 1250g of woody incense, grind into coarse powder, 500g of Evodia rutaecarpa (made), add water and decoct twice, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, and the decoction time is 2 times each time. hour, combined the decoction, filtered, and the filtrate was allowed to stand for 24 hours, and the supernatant was concentrated into an extract with a relative density of 1.20 (40°C), and ethanol was added to make the alcohol content 65%, stirred evenly, left for 24 hours, and taken The ethanol was recovered from the supernatant, concentrated into an extract, and the extract was vacuum-dried to obtain extracts of woody fragrance and Evodia rutaecarpa (manufactured). Take 100 g of the extracts of Muxiang, Evodia rutaecarpa (manufactured) and berberine hydrochloride, pulverize them respectively, pass through a 120-mesh sieve, and mix well. According to the weight ratio, it is the extract o...

Embodiment 2

[0023] Embodiment 2: Get 625g of woody incense, grind it into coarse powder, add 250g of Evodia rutaecarpa (manufactured), add 60% ethanol, the amount of addition is 8 times the amount for the first time, 6 times the amount for the second time, heat and reflux 2 times, the first time 2 hours, the second time 1.5 hours, filter, recover ethanol from the filtrate and concentrate to the extract, and dry the extract in vacuum to obtain the extracts of woody fragrance and Evodia rutaecarpa (manufactured). Take 100 g of the extracts of Muxiang, Evodia rutaecarpa (manufactured) and berberine hydrochloride, pulverize them respectively, pass through a 120-mesh sieve, and mix well. The ratio by weight is woody, Evodia rutaecarpa (production) extract and berberine hydrochloride: the ratio of mixed matrix=1:2 (mixed matrix is ​​polyethylene glycol 6000 : polyethylene glycol 4000 According to the formula of 1:0.2), add it into the melted mixed matrix (90°C), stir evenly, drop into the sime...

Embodiment 3

[0024] Example 3: In this example, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated through the extracts of Muxiang and Evodia rutaecarpa (manufactured) and berberine hydrochloride and different matrix formulations, so as to determine the (manufacturing) the weight ratio of extract and berberine hydrochloride to single or mixed matrix.

[0025] The test of the extracts of Muxiang, Evodia rutaecarpa (manufactured) and berberine hydrochloride (both 1 part) and different matrix formulations

[0026]

[0027] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / min.

[0028] 2. The above results show that all the indicators of No. 4-11 tests are good, that is, the extracts of Muxiang, Evodia rutaecarpa (manufactured) and berberine hydrochloride to the...

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PUM

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Abstract

The invention relates to a medicinal dripping pill for treating intestine diseases and its preparation, wherein the medicament possesses functions of reducing fever, removing dampness, regulating flow of qi and relieving pain, and the medicament is prepared from Chinese medicinal materials of banksia rose, evodia rutaecarpa benth through steps of extracting, palletizing berberine hydrochloride into fines, and mixing with drop pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying.

Description

[0001] technical field book [0002] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to Changkang dripping pills and a preparation process thereof. Background technique [0003] Diarrhea is a common clinical disease and frequently-occurring disease, and its causes are various, such as cold-damp diarrhea, damp-heat diarrhea, food-injured diarrhea, liver depression and spleen-deficiency diarrhea, spleen-deficiency diarrhea, kidney-yang deficiency diarrhea, etc. Treatment of diarrhea When dialectical medicine. Damp-heat diarrhea is the evil of damp-heat, accumulating in the spleen and stomach, pouring into the intestinal tract, and losing its ability to pass transformation, so the diarrhea is as thin as water, and the amount is frequent. Sticky and greasy in dampness, acute in heat, steaming with dampness and heat, obstructing gastrointestinal qi, so the diarrhea is urgent, yellow and smelly, or a little mucus, abdo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/20A61P1/12A61K31/4375
Inventor 陈茜滕慧丽
Owner 陈茜
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