Diltiazem hydrochloride and its prepn

A technology of diltiazem hydrochloride and diltiazem, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of low bioavailability, long disintegration time, and influence on drug efficacy, and achieve bioavailability. High temperature, reduce dust pollution, quick onset effect

Inactive Publication Date: 2006-05-17
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have disadvantages such as long disintegration time, slow onset of action, and low bioavailability, which affect the full play of the drug effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0019] Embodiment: every 1000 grains of diltiazem hydrochloride dripping pills ratio of raw and auxiliary materials

[0020] Example

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PUM

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Abstract

The present invention discloses one kind of diltiazem hydrochloride dripping pill and its preparation process. The diltiazem hydrochloride dripping pill is compounded with diltiazem hydrochloride and dripping pill matrix. The present invention has high bioavailability, high stability, convenient taking, fast disintegration and dissolving, high leaching degree, fast medicine releasing, fast acting, simple production process, low cost and other features.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, in particular to a diltiazem hydrochloride drop pill prepared from diltiazem hydrochloride and a drop pill base. Background technique [0002] Diltiazem hydrochloride, the chemical name is cis-(+)-5-[(2-dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-acetoxy 2,3-dihydro- 1,5-Benzothiazepine-4(5H)-one hydrochloride is a calcium ion channel blocker that can effectively dilate epicardium and subendocardium coronary arteries and relieve spontaneous angina or Angina pectoris caused by coronary artery spasm induced by ergometrine; by slowing heart rate and lowering blood pressure, reducing myocardial oxygen demand, increasing exercise tolerance and relieving exertional angina pectoris; it can relax vascular smooth muscle, reduce peripheral vascular resistance, and lower blood pressure; The degree of blood pressure reduction is related to the degree of hypertension. Normal blood pressure only slightly lowe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/554A61K9/20A61P9/10
Inventor 陈茜滕慧丽
Owner 陈茜
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