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Dripping pills for improving sleep quality and its preparation process

A technology of Liermian and dripping pills, which can be applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems that capsules are easy to absorb moisture or break, affect the full effect of the drug, and have low bioavailability , to achieve the effects of labor protection and environmental protection, GMP management, and high bioavailability

Inactive Publication Date: 2007-07-04
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of the preparation technology of such conventional preparations, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, thus affecting the full play of the drug effect.
And the capsule is easy to absorb moisture or break

Method used

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  • Dripping pills for improving sleep quality and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Take 1050g of Coptidis Rhizome, decoct twice with water, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, the decoction time is 3 hours for the first time, 2 hours for the second time, and the decoction is combined , filtered, and the filtrate was concentrated to an extract with a relative density of 1.18-1.20 (40°C), adding ethanol to make the alcohol content 65%, stirring evenly, standing for 12 hours, taking the supernatant to recover ethanol, and concentrating into an extract , vacuum-dried the extract to obtain Coptis chinensis extract. Take 175g of cinnamon, add 60-80% ethanol, add 6-8 times the amount for the first time, 4-6 times the amount for the second and third times, heat and reflux 3 times, the first time for 2 hours, the second time The second time and the third time are each 1.5 hours, filtered, the filtrate recovers ethanol, concentrates to the extract, and vacuum-dries the ext...

Embodiment 3

[0023] Example 3: In this example, through Coptis chinensis, cinnamon extract and different matrix formulations, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated to determine the weight ratio of Coptis chinensis, cinnamon extract and single or mixed matrix .

[0024] Coptis chinensis, cinnamon extracts and different matrix formula tests (extracts are 1 part)

[0025]

[0026] 9

Polyethylene glycol 6000: carboxymethyl starch

Sodium = 1:0.2 (5 parts)

+++

＜10

+++

＜10

+++

10

Polyethylene glycol 6000: Poloxamer

=1:0.2 (1 part)

+++

＜10

+++

＜10

+++

11

Polyethylene glycol 6000: Poloxamer

=1:0.2 (5 parts)

+++

＜10

+++

＜10

+++

[0027] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperatu...

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PUM

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Abstract

The invention provides medicinal dripping pills and process for preparation, wherein the pills have the functions of set one's mind at ease and relaxing tendon and vein, and can be used for treating breakdown between the heart and the kidney, insomnia and cardiopalmus, the medicament is prepared from Chinese medicinal materials of goldthread root and Cinnamomum cassia through extracting, and mixing extractive with dripping pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Liermian dripping pill and a preparation process thereof. Background technique [0002] Insomnia is a common sleep disorder. About 10% of people in my country have sleep disorder, which affects people's health and quality of life. There are many causes of insomnia, one of which is insomnia of heart-kidney disharmony type. Heart-kidney disharmony is a syndrome differentiation type in traditional Chinese medicine. Heart-kidney disharmony type insomnia is often accompanied by dizziness and insomnia, restlessness and dreaminess, palpitations and forgetfulness, dizziness and tinnitus, dry mouth and throat, sore waist and knees, or hot flashes, night sweats and short urination. Red and so on. Liermian preparation has the functions of clearing the heart and reducing fire, and communicating with the heart and kidney, and has a good curative e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/20A61P25/20
Inventor 陈茜滕慧丽
Owner 陈茜
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