Oral instant microcapsule tablet prepared from rhizoma chuanxiong volatile oil and preparation method of oral instant microcapsule tablet

Abstract

The invention discloses an oral instant microcapsule tablet prepared from rhizoma chuanxiong volatile oil and a preparation method of the oral instant microcapsule tablet. The preparation method comprises the following steps: uniformly mixing a capsule material (ethyl cellulose) with a solvent (ethyl acetate) to obtain a mixture, uniformly mixing the mixture with a capsule core (rhizoma chuanxiong volatile oil) so as to obtain an oil phase, and uniformly mixing an emulsifying agent (lauryl sodium sulfate) and a saturated water solution of the solvent (ethyl acetate) so as to obtain a water phase, wherein the concentration of the emulsifying agent is 0.8%-1.2%; dropwise adding the oil phase into the water phase at a stirring speed of 500rpm-600rpm so as to obtain an emulsion, and washing, so as to obtain microcapsules, wherein the mass ratio of the capsule material to the capsule core is (1.5 to 1)-(2.5 to 1), and the volume ratio of the oil phase to the water phase is (1 to 4)-(1 to 6); and (2) uniformly mixing 40%-60% of microcapsules and a disintegrating agent (3%-7% of cross-linked povidone and 8%-12% of sodium carboxymethyl starch), a filling agent (10%-30% of lactose and 8%-12% of microcrystalline cellulose) and a lubricating agent (4%-6% of micropowder silica gel), and tabletting. The prepared oral instant microcapsule tablet is short in disintegration time and high in bioavailability.

Description

technical field [0001] The invention relates to an oral instant microcapsule tablet of Chuanxiong volatile oil and a preparation method thereof. Background technique [0002] The chemical properties of volatile oil are unstable, insoluble, and irritating, which lead to its poor druggability. Microencapsulation technology has obvious effects in improving the stability of volatile oil in traditional Chinese medicine. Oral instant tablets can provide convenience for patients with poor swallowing function and inconvenient water intake, especially for the elderly, children and patients with dysphagia. At present, the volatile oil of Rhizoma Chuanxiong is often subjected to β-cyclodextrin inclusion treatment, and then applied to the preparation of various dosage forms such as capsules and gel ointments. However, β-cyclodextrin inclusion does not have strict requirements on the particle size of the inclusion compound, which has limitations in the development and application of som...

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defect of the lack of Chuanqiong volatile oil instant tablets in the prior art, and innovatively provide a Chuanxiong volatile oil oral instant microcapsule tablet and its preparation method

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