Cinnarizine drop pills, and preparation method

A technology of cinnarizine and dropping pills, which is applied in the field of cinnarizine dropping pills and its preparation, can solve the problems of difficulty in adapting to swallowing, affecting the full effect of the drug, and low bioavailability, so as to be beneficial to human body absorption, Increased bioavailability, high bioavailability effect

Inactive Publication Date: 2007-10-10
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of these conventional preparation technology, such oral preparations have disadvantages such as long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of the drug effect.
During storage, it is easy to split, change color, absorb moisture, etc., and the quality is unstable
It is also difficult to accommodate patients who have difficulty swallowing

Method used

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  • Cinnarizine drop pills, and preparation method
  • Cinnarizine drop pills, and preparation method
  • Cinnarizine drop pills, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: In this example, the formulation of cinnarizine and a single matrix is ​​used to operate according to the preparation method in [Specific Embodiment], the coolant is simethicone oil, dripping pills are made, and the roundness, pill weight difference, Hardness, dissolving time, etc. are used as indicators to observe the influence of the weight ratio of the drug to the single matrix on the product involved in the present invention. The test results are shown in Table 1.

[0027] Table 1 Tests of drug and single matrix formulation (all drugs are 1 part)

[0028]

[0029] 5

Polyethylene glycol 6000 (3 parts)

+++

＜10

+++

＜15

+++

6

Polyethylene glycol 6000 (9 parts)

+++

＜10

+++

＜15

+++

7

Polyethylene glycol 10000 (1 part)

too thick to drip

8

Polyethylene glycol 10000 (3 parts)

+++

＜10

+++

＜15

++...

Embodiment 2

[0032] Example 2: In this example, the formula of cinnarizine and mixed matrix is ​​used, and the preparation method in [specific implementation] is operated. The coolant is simethicone oil, and dripping pills are made, and the roundness, pill weight difference, Hardness, dissolving time etc. are investigation indexes, observe the influence of the weight ratio of medicine and mixed matrix on the product involved in the present invention, test result is shown in Table 2.

[0033] Table 2 Drug and mixed matrix formulation test (1 part of drug)

[0034]

[0035] 7

Polyethylene glycol 6000: poloxamer = 1:

0.2 (1 part)

+++

＜10

++

＜15

++

8

Polyethylene glycol 6000: poloxamer = 1:

0.2 (3 parts)

+++

＜10

+++

＜15

+++

9

Polyethylene glycol 6000: poloxamer = 1:

0.2 (9 parts)

+++

＜10

+++

...

Embodiment 3

[0038] Embodiment 3: In this embodiment, different coolants are selected, and the coolant is simethicone, liquid paraffin, vegetable oil, and polyethylene glycol is selected as a single matrix 6000 , the mixed matrix chooses polyethylene glycol 6000 : the formula of poloxamer=1:0.2, operate according to the preparation method in [the specific embodiment], drip dripping pill, select roundness, pill weight difference, hardness, dissolving time etc. as investigation index, observe different The impact of coolant on the products involved in the present invention, the test results are shown in Table 3.

[0039] Table 3 Experiments using different coolants (drug: matrix = 1:3)

[0040]

[0041] 5

vegetable oil

single

++

＜10

+++

＜15

++

6

vegetable oil

mix

++

＜10

+++

＜15

++

[0042] Note: 1. The cooling temperature is 8-5°C; the heat preservation temperature of the d...

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Abstract

A dripping pill of cinnarizine for treating cerebrovascular obstacle, cerebral thrombus and cerebral arteriosclerosis is prepared from the cinnarizine and the matrix of dripping pill. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, in particular to a cinnarizine dripping pill formulated from a drug cinnarizine (Cinnarizine) and a dripping pill base for the treatment of cerebrovascular disorders, cerebral embolism, and cerebral arteriosclerosis, and its preparation method. Background technique [0002] Cerebrovascular disease is a general term for brain diseases caused by disorders of blood supply to the brain. Clinically, acute cerebrovascular disease is more common. Mild cases gradually recover after 3-6 months, and can take care of themselves, and even engage in pre-ill work; severe cases become comatose, die, or leave serious sequelae, and even need to stay in bed for a long time, and eventually die of complications such as lung infection and bed sores . According to the Chinese health statistics of the Ministry of Health in the past 10 years, cardiovascular and cerebrovascular diseases have always been the leading c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K9/20A61P9/00
Inventor 陈茜滕慧丽
Owner 陈茜
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