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Extraction for radix cynanchi bungei polysaccharide and oral lozenge preparation

A technology of Baishouwu and buccal tablets, which can be applied in the direction of medical preparations containing active ingredients, sheet-like delivery, organic active ingredients, etc., and can solve the problem of less deep processing, etc.

Inactive Publication Date: 2005-02-23
SHANDONG AGRICULTURAL UNIVERSITY
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] At present, Baishouwu in the market is mainly raw materials and Baishouwu powder, with less deep processing

Method used

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  • Extraction for radix cynanchi bungei polysaccharide and oral lozenge preparation
  • Extraction for radix cynanchi bungei polysaccharide and oral lozenge preparation
  • Extraction for radix cynanchi bungei polysaccharide and oral lozenge preparation

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Embodiment Construction

[0026] 1. Preparation of polysaccharides from Polygonum multiflorum

[0027] Take Radix Polygoni Multiflori powder 100g (1), reflux extraction with 500ml 95% ethanol (2) twice, each time for 2h, filter under reduced pressure, add water 1000ml to the solid residue, extract at 100°C for 2h, and extract once. The extract was concentrated to 60ml under reduced pressure at 60°C, 250ml of 95% ethanol was added, centrifuged at 4000r / min, the polysaccharide was precipitated, the precipitate was washed twice with 95% ethanol, and the precipitate was dried to dryness at 60°C by vacuum drying (19 ), pulverized (20) to obtain the crude polysaccharide powder of Radix Polygoni Multiflori (21), the extraction rate was 9%, and the yield was 82%.

[0028] 2. Preparation of polysaccharides from Radix Polygoni Multiflori

[0029] Take 100g of Radix Polygoni Multiflori powder, extract twice with 500ml of 95% ethanol under reflux, each time for 2h, and filter under reduced pressure; add 1000ml of...

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Abstract

Extraction of cynanchum bunqei polysaccharide and preparation of its oral tablets pharmaceutics are achieved by: pulverizeing cynanchum bunqei (granular <4mm), Reflux extracting two to three times in 3-10 times alcohol . The extracted liquid is concentrated to recover for other uses. The extracted solid residues was extracted three times in certain ratio 1: 8-20 of materials and water at 80deg.C-100deg.C for 1-3 h, then incorporating the aquatic extracted liquid. The aquatic extracted liquid was concentrated, depositing with alcohol and drying to obtain cynanchum bunqei crude polysaccharide. The aquatic extracted liquid was destarch by enzyming, deproteinizing by chloroform- normal butanol method, depositing with alcohol and drying to get cynanchum bunqei total polysaccharide. The animal testing in vivo and testing in vitro prove that, the polysaccharide and total polysaccharide are capable of preparing pharmaceuticals as componets of immunoregulation fuctions and health-care food such as buccal tablets and oral liquid.

Description

(1) Technical field [0001] The invention relates to the extraction of Polygonum multiflorum polysaccharide and the preparation technology of buccal tablets. (2) Background technology [0002] Plant polysaccharides, especially plant polysaccharides derived from nourishing traditional Chinese medicine, have a variety of physiological functions. Therefore, this type of polysaccharide has attracted much attention, and the market prospect for the development of medicines and health products is good. [0003] The traditional Chinese medicine Baishouwu mainly comes from the tuber roots of three species of plants in the genus Evelynaceae. One is Baishouwu (Cynanchum bungei Decne), also known as Taishan Polygonum multiflorum, Jiye Niupixiao, etc. It is the first of the four famous medicines in Mount Tai, and Baishouwu genuine product is included in the Pharmacopoeia of the People's Republic of China; C. auriculatum Royle ex Wight), the main product in the market is Baishouwu; the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/715C08B37/00
Inventor 王建华高丽君
Owner SHANDONG AGRICULTURAL UNIVERSITY
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