62results about How to "Short sequence" patented technology

A microwave hyperthermia apparatus that can be inserted into the body which includes a hollow central tube for the insertion of radioactive therapy sources. The use of a coaxial transmission line impedance transformation along the insertable portion of the coaxial cable enables a reduction in the characteristic impedance by increasing the outer diameter of the inner coaxial conductor so that the center conductor can be a metal tube. If the ratio of the outer coaxial conductor diameter vs. the inner coaxial conductor is decreased, the characteristic impedance of the transmission line is lowered. This enables the inner conductor diameter to increase sufficiently to make the central hollow opening large enough to receive standard radioactive sources therein. This provides for a good impedance match that improves microwave energy efficiency while at the same time permitting a large hollow center opening. The combination of the microwave antenna device and brachytherapy sources provides for enhanced effectiveness when the two treatments are delivered simultaneously or in close time proximity to each other.

A method of accessing or receiving information stored in electronic or other form, the method comprising the use of alpha-numeric sub-codes, wherein the codes comprise one or more alpha-numeric sub-codes in a hierarchical structure and wherein the sub-codes and/or codes are used to identify, describe, define, classify or encode a description of the content of said information.

A system for detecting picture freeze within a video signal wherein a video signal processing portion for connection to a video signal source comprising digital video luma samples and digital video clock and timing signals separately detects motion across the vertical axis of the video picture and across the horizontal axis of the video picture and wherein a frozen picture indicating portion connected to the output of the video signal processing portion determines the number of motionless video picture frames occurring since the last video picture frame in which motion was detected to indicate picture freeze when the number of motionless video picture frames reaches a predetermined value. A noise reduction threshold signal is applied to the video signal processing portion to distinguish motion from background noise in a video signal.

A hydraulic module for a hydraulic antilock braking system for a two-wheeled vehicle, the hydraulic module including a first hydraulic connection for connecting the hydraulic module by a hydraulic line to a brake-actuating device; a second hydraulic connection for connecting the hydraulic module by a hydraulic line to a wheel brake; an inlet valve for connecting and disconnecting the first hydraulic connection to/from the second hydraulic connection; an outlet valve for connecting and disconnecting a pressure accumulator to/from the second hydraulic connection; and a housing in which the inlet valve and the outlet valve are accommodated and which provides the first hydraulic connection and the second hydraulic connection.

The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are versatile vehicles for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. Any kind of compound, but in particular drugs, such as interferons, viral reverse transcriptase inhibitors or core assembly inhibitors, and/or labels can be specifically targeted to the liver and so be enriched in the liver. This liver targeting can further be used for the targeted diagnosis, prevention and/or treatment of liver diseases or disorders, such as hepatitis, malaria, hepatocellular carcinoma (HCC), as well as for the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified preS-derived peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to a method for the combined treatment of a liver disease and the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates also to the use of the preS-derived peptides in gene therapy and the delivery of immunogenic epitopes for hepatocyte-mediated antigen presentation to activate liver-directed immunological responses.

A novel approach of repeated adaptation is provided that can be applied to either one or both of channel estimation and/or equalization. From an incoming data packet that includes data and a training sequence, a modified data packet is generated that includes the data, the training sequence, and at least one additional copy of the training sequence. From the format of this modified data packet, the same training sequence can be used over and over again a desired number of times to perform channel estimation and subsequent calculation of equalizer tap coefficients. Alternatively, the same training sequence can be used over and over again a desired number of times to converge the equalizer coefficient taps directly without doing any preliminary channel estimation. Generally, either of these approaches can be characterized as a cyclic adaptation operation that provides improved performance without incurring any reduction in throughput of the communication channel.

The invention discloses an intelligent community safety monitoring system and a safety monitoring method. The system comprises a monitoring cloud, a video monitoring unit, an entrance monitoring unit, an outlet monitoring unit, a field prompting unit, an automatic alarm unit and a hand-held terminal. The monitoring cloud is arranged in an equipment operation room; the video monitoring unit is connected with the monitoring cloud through an electric signal transmitted in the electronic connecting line; the entrance monitoring unit is installed at an entrance of a community and is connected withthe video monitoring unit via an electric signal transmitted in the electronic connecting line; the exit monitoring unit is installed at a community exit and is connected with the video monitoring unit through an electric signal transmitted in the electronic connecting line, the on-site prompting unit is installed on the community monitoring device, and the automatic alarm unit is connected withthe monitoring cloud through an electric signal transmitted in the electronic connecting line. According to the smart community safety monitoring system and the safety monitoring method, the identities of people entering and exiting the community can be identified in time, and the community comfort level index is improved.

The invention relates to a production unit (1), in particular a bending press, and a method of operating the latter in order to shape workpieces of sheet metal between two press beams (15, 16) equipped with bending tools (36, 37) and displaceable relative to one another by means of a drive system (27), and having a control unit (47). The control unit (47) incorporates a detection system and has at least one detection means which is connected so as to communicate with the detection system in order to transmit data and/or signals.

Selectively exciting bulk protons in certain tissue components, e.g. water, while suppressing the excitation of others, e.g. fat, can lead to images with better contrast for desired features. The invention provides binomial, off-resonance RF excitation pulses for differentiating tissue excitation that yields a larger fat suppression that prior art water excitation methods. Proper balancing of the frequency offset and the pulse duration with a relative phase offset between the pulses leads to large-bandwidth pass- and stopbands for water and fat, respectively. The pulses can be applied with short, or even zero, interpulse delay, leading to substantial time savings in the imaging sequence.

The invention relates to a mercury ion fluorescence detection method and a kit for rapid detection of mercury ions in water. Specifically, original MSO (mercury-specific oligonucleotide) is optimized and modified, fluorescence modified and non-fluorescence modified optimized MSO is adsorbed to the surface of GO (graphene oxide) by means of a non covalent bond's (pi-pi stacking) acting force, and MSO and mercury ions are utilized to form a T-Hg<2+>-T structure, so that fluorescently-labeled MSO can be released from the GO surface, and fluorescence signals can be restored. By detecting the change of fluorescence signals in a solution, quantitative detection of mercury ions in the solution can be realized. The method provided in the invention can realize convenient analysis of mercury ions without requiring any special condition. The lowest detection limit is 10pM, the sensitivity of original methods is enhanced by 18 times, and the the cost of DNA synthesis is reduced. Thus, the invention provides a simple, efficient, sensitive and cost-effective solution for monitoring mercury ion pollution in water, and the solution is easy to promote and use.

The invention relates to a myocardial specific promoter, which is a part of a TroponinI promoter and comprises a component (TATA/MEF-2) with rich A/T, two GATA components and an area (comprising CACC box and Sp1 element) with rich cytosine; and preferably, the myocardial specific promoter is a part from the -791st site to the 67th site of a TNNI3 gene, and more preferably, the myocardial specific promoter is a part from the -234th site to the 67th site of the TNNI3 gene. The invention also relates to a nucleic-acid construction body, a carrier and a reconstitution cell comprising the promoter. The invention also relates to an application of the promotor for controlling the specific expression of target genes in myocardium and an application for preparing a medicine for preventing or treating cardiovascular disease. The promoter has the advantages that the target gene can be controlled for high expression to myocardial specificity and a new path for preventing or treating the cardiovascular disease is opened up.

The invention relates to a single-gene bispecific antibody capable of targeting CTLA4 and PD-1. The single-gene bispecific antibody comprises a first target binding region, a second target binding region and an Fc region from an N end to a C end in sequence, wherein the first target binding region is connected with the second target binding region through a connecting fragment, and the first target binding region targets one of the CTLA4 and PD-1, the second target binding region targets the other of the CTLA4 and PD-1. The invention also relates to application of the single-gene bispecific antibody in preparation of antitumor drugs. The invention also relates to an AAV bispecific antibody expression vector. The single-gene bispecific antibody can effectively target the PD1 and CTLA4, is short in sequence and simple in structure, is suitable for construction of an AAV virus-based antibody expression vector, the antibody expression vector can be directly injected, and the maintenance time of the antibody in the body is prolonged.

The invention relates to a method for analyzing a genomic region of an organism, comprising four major parts. The first part involves the isolation of mRNA from a selected organism that is used for the preparation of small single stranded DNA fragments with one adaptor containing an affinity label. These DNA fragments are used in part three. In the second part, genomic DNA from the same or a related organism is isolated. This genomic DNA is fragmented and ligated to adaptor molecules. In the third part, these genomic fragments are hybridized with single stranded DNA fragments from part one, and the hybrids formed in this process are used for synthesis of DNA fragments. These fragments will be used in part four which involves sequencing of these fragments using one of the available high throughput sequencing methods.

The invention is an actuator which includes at least one control element which has thermally activatable transducer material and which, in response to the supply or dissipation of energy, changes from a first shape state into a second shape state, and a mechanical energy store, which is functionally connected to the control element and, when the control element is in the second shape state, exerts on the control element a restoring force which returns the control element to the first shape state. The mechanical energy store includes an elastomer body, which at least in some regions is in direct physical and thermal contact with the control element, the elastomer body is connected in a spatially fixed manner to the control element in at least two spatially separated joining regions along the control element.

The invention discloses an identification method of rice bacterial leaf blight resistance and an application of miRNA1425 genetic locus, and belongs to the field of biotechnology. The identification method comprises the following steps: inoculating paddy rice to be detected and infected paddy rice; separating miRNA genes of the paddy rice to be detected and the infected paddy rice; detecting the expressions of the miRNA genes; and determining whether the paddy rice to be detected is resistant to bacterial leaf blight. The invention further discloses the application of the miRNA1425 genetic locus in identification of rice bacterial leaf bright resistance. The invention uses the transcription of the miRNA1425 gene locus to identify whether paddy rice is resistant to bacterial leaf blight, and achieves success. The transcription of the miRNA1425 gene locus provided by the invention is detection based on expression level, so as to avoid misjudgment caused by bacterial leaf blight resistance gene silencing; and the identification method provided by the invention does not use the conventional DNA linkage tracer method, so as to avoid misjudgment caused by untightness of DNA linkage, improve the detection accuracy and avoid unnecessary production loss.

The invention relates to an MSO/GO (Mercury-Specific Oligonucleotide/Graphene Oxide) based mercury ion detecting method and a kit for the rapid detection of mercury ion in water. According to the invention, fluorescence-modified and not-fluorescence-modified optimized MSO is adsorbed to the surface of GO by utilizing the acting force of non-covalent bonds (pi-pi superposition); a structure of T-Hg2+-T is formed by the MSO and the mercury ion to ensure that the fluorescently-labeled MSO is released from the surface of the GO and the fluorescence signal is recovered; and the quantitative determination of the mercury ion in solution is realized through detecting the changes of the fluorescence signal in the solution. The method disclosed by the invention has the advantages that the convenient and fast analysis of the mercury ion can be realized without any special condition; the lowest detection limit is 10pM; the sensitivity is greatly increased; the DNA (DeoxyriboNucleic Acid) synthetizing cost is reduced; a solution which is simple, convenient, efficient, sensitive and cost performance is provided for the monitoring of the pollution of the mercury ion in the water; and the method is easy to popularize.

The invention discloses a macrobrachium rosenbergii estrogen-related receptor gene ERR. The nucleotide sequence of the gene ERR is shown as SEQ ID NO:1, and the amino acid sequence of the gene ERR is shown as SEQ ID NO:2. The invention further discloses application of the recombined macrobrachium rosenbergii estrogen-related receptor gene ERR to environmental internal-secretion interfering-substance detection and pollution assessment, and macrobrachium rosenbergii ERR protein has important application value in the aspects of natural water environment internal-secretion interfering-substance (like NP) detection and pollution assessment.

The invention provides a single-stranded DNA aptamer specifically binding to cardiac troponin I (hereinafter referred to as cTnI protein). The single-stranded DNA aptamer comprises a nucleotide sequence as shown in any one of SEQ ID Nos.1-3. The nucleic acid aptamer provided by the invention can also be various similar sequences with high homology or derivatives obtained from the sequences provided by the invention. The nucleic acid aptamer provided by the invention has stronger binding capacity with cardiac troponin I and has a shorter sequence, and also has the advantages of small molecularweight, easiness in synthesis, short production time, lower synthesis cost and the like. The invention also provides an application of the single-stranded DNA aptamer. The single-stranded DNA aptamercan be used for cTnI protein purification or cTnI protein detection independently or in combination. The invention also provides a kit for detecting the cTnI protein, and the kit comprises the single-stranded DNA aptamer provided by the invention.