Tumor active-targeting nano drug delivery system capable of reversing drug-resistance
A nano-drug delivery system and active targeting technology, which can be used in anti-tumor drugs, drug combinations, anti-infective drugs, etc., and can solve the problems of low drug loading, capture, and poor hydrophilicity
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[0021] Preparation and antitumor activity of doxorubicin tumor-targeted drug delivery system
[0022] 1 Objective: To evaluate the antitumor activity of DOX-loaded lipid-mixed PLGA nanoparticles.
[0023] 2 Research methods:
[0024] 2.1 Determination of encapsulation efficiency and drug loading
[0025] The nanoparticles were dissolved in DMSO to destroy the nanoparticle structure, and the encapsulation efficiency and drug loading were detected by HPLC-MS / MS.
[0026] Drug loading = (the amount of drug wrapped in the drug delivery system / weight of the drug delivery system) × 100%
[0027] Encapsulation efficiency = (actual drug loading / dosage) × 100%
[0028] 2.2 Evaluation of acid sensitivity characteristics
[0029] The lipid-mixed PLGA nanoparticles were weighed, and the Zeta potential of the lipid-mixed PLGA nanoparticles in different pH (pH 5.0, pH 6.5 and pH 7.4) media was analyzed by laser particle size analyzer.
[0030] 2.3 Cytotoxicity evaluation
[0031] Huma...
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