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Micro-emulsion thermosensitive gel for skin external use and preparation method thereof

A temperature-sensitive gel and microemulsion technology, which is applied in the field of medicine and achieves the effects of high biodegradability, large transdermal penetration and high drug concentration

Inactive Publication Date: 2012-08-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about the microemulsion thermosensitive gel that can promote skin wound healing

Method used

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  • Micro-emulsion thermosensitive gel for skin external use and preparation method thereof
  • Micro-emulsion thermosensitive gel for skin external use and preparation method thereof
  • Micro-emulsion thermosensitive gel for skin external use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1. Preparation of resveratrol microemulsion thermosensitive gel

[0037] (1) Preparation of liquid A

[0038] Dissolve 0.04g resveratrol in 4g glycerol triacetate, mix evenly, add 3.5g polyoxyethylene castor oil EL, 7g alkyl glucoside and 5.5g 1,2-propanediol, and ultrasonically mix evenly to obtain drug-containing Inner phase; place it on a magnetic stirrer at room temperature, stir at a constant speed of 300r / min, and slowly add deionized water dropwise to the inner phase containing the medicine while stirring, to a total weight of 50g, forming clear and transparent resveratrol Alcohol microemulsion, namely liquid A;

[0039] (2) Preparation of liquid B

[0040] Take 19.5g of poloxamer 407 and 0.5g of poloxamer 188, add water to 50g, stir evenly and let stand to make it fully swell and disperse evenly to obtain liquid B;

[0041] (3) Preparation of resveratrol microemulsion thermosensitive gel

[0042] Slowly add liquid A into liquid B, stir evenly to o...

Embodiment 2

[0044]Embodiment 2, preparation resveratrol microemulsion thermosensitive gel

[0045] (1) Preparation of liquid A

[0046] Dissolve 0.06g of resveratrol in 5g of ethyl oleate, mix well, add 8g of polyoxyethylene castor oil EL and 10g of 1,2-propanediol, and mix evenly by ultrasonic to obtain the drug-containing inner phase; On a magnetic stirrer, stir at a constant speed of 300r / min, slowly drop deionized water into the drug-containing inner phase while stirring, to a total weight of 50g, and form a clear and transparent resveratrol microemulsion, namely liquid A;

[0047] (2) Preparation of liquid B

[0048] Take 19g of poloxamer 407 and 0.1g of poloxamer 188, add water to 50g, stir evenly and let stand to make it fully swell and disperse evenly to obtain liquid B;

[0049] (3) Preparation of resveratrol microemulsion thermosensitive gel

[0050] Slowly add liquid A into liquid B, stir evenly to obtain resveratrol microemulsion temperature-sensitive gel, put the resveratr...

Embodiment 3

[0052] Example 3. Preparation of Resveratrol Microemulsion Thermosensitive Gel

[0053] (1) Preparation of liquid A

[0054] Dissolve 0.02g resveratrol in 6g isopropyl myristate, mix evenly, add 7.5g lecithin and 12g polyethylene glycol 400, and ultrasonically mix evenly to obtain the drug-containing inner phase; then place it in On a magnetic stirrer, stir at a constant speed of 300r / min, slowly drop deionized water into the drug-containing inner phase while stirring, to a total weight of 50g, and form a clear and transparent resveratrol microemulsion, namely liquid A;

[0055] (2) Preparation of liquid B

[0056] Take 17g of poloxamer 407 and 0.1g of poloxamer 188, add water to 50g, stir evenly and let stand to make it fully swell and disperse evenly to obtain liquid B;

[0057] (3) Preparation of resveratrol microemulsion thermosensitive gel

[0058] Slowly add liquid A into liquid B, stir evenly to obtain resveratrol microemulsion temperature-sensitive gel, put the resv...

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Abstract

The invention relates to the technical field of medicines, and in particular relates to a micro-emulsion thermosensitive gel for skin wound healing and a preparation method thereof. The micro-emulsion thermosensitive gel disclosed by the invention is composed of medicines, oil phase, a surfactant, a cosurfactant, a gel matrix and water, wherein the medicines are selected from resveratrol, paeonol and matrine. Proved by animal experiments, the prepared micro-emulsion thermosensitive gel has the characteristics of nearly no irritation to skin, safety in use, large percutaneous infiltration quantity, high percutaneous infiltration rate, long retention time of the micro-emulsion gel in the skin, high medicine concentration in the skin, good slow-release effect and good effect of promoting the healing of skin wound injury. The micro-emulsion thermosensitive gel disclosed by the invention has the advantages of simpleness in preparation method, low cost, convenience and safety in use and capability of effectively promoting the skin wound healing. According to the invention, a novel dosage form is provided for treating the skin wound.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to an external microemulsion temperature-sensitive gel for skin wound healing and a preparation method thereof. Background technique [0002] Skin wound injuries caused by burns, mechanical trauma, chemical corrosion, or diseases (such as diabetic gangrene, severe skin diseases, and surgical incisions) are common and frequently-occurring clinical diseases. At present, there are not many clinical treatment methods for this kind of disease. One is to let the patient rest and wait for the wound to heal itself, and at the same time use anti-infective drugs to prevent wound infection; the other is to use some biological drugs that can promote the growth of epidermal cells, such as recombinant bovine Basic fibroblast growth factor solution for external use (trade name: Beifuji), etc., are externally applied to the affected area with gauze to promote wound healing. There are big problems i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/05A61K31/12A61K31/4375A61K47/34A61P17/02
Inventor 刘继勇吴建华高申王峥涛朱全刚杨帝顺郝天龙房俨潘勇华尤本明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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