Use of nano structured lipid carrier drug feeding system

Abstract

The invention discloses an application of nanometer structure lipid carrier administration system in the antineoplastic drug to reverse the multiple-drug tolerance of tumour cell, which comprises the following parts: solid lipid material, liquid lipid material and antineoplastic drug, wherein the rate of the liquid lipid (such as oleic acid) is 0-30wt%; the solid lipid is selected from monoglyceride; the liquid lipid is oleic acid; the antineoplastic drug is Paclitaxel or adriablastina. The invention has highly effective cell uptaking and cytolymph condensing function with packing molecular target in the antineoplastic drug of cell, which avoids P-glucoprotein in the drug tolerant cytolymph from identifying the antineoplastic drug to reduce exclusion.

Description

technical field

[0001] The invention relates to the application of the nanostructure lipid carrier delivery system, and mainly relates to the application of the nanostructure lipid carrier delivery system in anti-tumor treatment and reversal of tumor multidrug resistance. Background technique

[0002] Tumor has always been a major disease that directly threatens human health. Due to the lack of molecular targeting of drugs themselves, tumor chemotherapy has major treatment problems such as low cure rate, multidrug resistance, and huge toxic and side effects. One of the important reasons for the failure of clinical chemotherapy is the resistance of tumor cells to chemotherapy drugs. The cause of death of most cancer patients is directly or indirectly related to the resistance of tumor cells to anti-tumor drugs. Therefore, finding and studying drug delivery systems that can reverse the drug resistance of drug-resistant tumor cells is one of the important strategies and direct...

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