Use of nano structured lipid carrier drug feeding system

A nanostructured lipid and drug delivery system technology, applied in liposome delivery, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as limited drug loading capacity and drug exclusion

Inactive Publication Date: 2008-02-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solid lipid nanoparticle drug delivery system also has some potential limitations, such as limited drug loading capacity, drug exclusion during storage, etc.

Method used

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  • Use of nano structured lipid carrier drug feeding system

Examples

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Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preparation and Application of Doxorubicin Monoglyceride Nanostructured Carrier Delivery System

[0016] 1) Preparation of Adriamycin Monoglyceride Nanostructured Carrier Delivery System

[0017] Take 60 mg of monoglyceride and 3 mg of doxorubicin respectively, weigh them accurately, add 6 mL of absolute ethanol, dissolve in a water bath at 70°C, and form an organic phase. Take distilled water as the dispersed phase, put it in a water bath at 70°C, and set it at 400r·min -1 Under the condition of mechanical stirring, the organic phase was injected into 60mL of the dispersed phase, and stirred for 5min to prepare the dispersion liquid of the doxorubicin monoglyceride nanostructured lipid carrier delivery system, and the dispersion liquid was prepared with 3mol L -1 HCl solution to adjust the pH to 1.2, at 20000r·min -1 Centrifuge for 10 min, add 0.1% Poloxamer (w / v) to the precipitate to redisperse, and use 1.0mol·L -1 The NaOH solution adjusts the pH to 7....

Embodiment 2

[0029] Example 2: Preparation and Application of Doxorubicin Monoglyceride / Oleic Acid Nanostructured Carrier Delivery System

[0030] 1) Preparation of doxorubicin monoglyceride / oleic acid nanostructure carrier drug delivery system

[0031] Take 60 mg of monoglyceride, 6 mg of oleic acid and 3 mg of doxorubicin, respectively, and weigh them accurately. Add 6 mL of absolute ethanol and dissolve in a water bath at 70°C. Take distilled water as the dispersed phase, put it in a water bath at 70°C, and set it at 400r·min -1Under the condition of mechanical stirring, the organic phase was injected into 60mL of the dispersed phase, and stirred for 5min to obtain the dispersion liquid of the doxorubicin monoglyceride / oleic acid nanostructured lipid carrier drug delivery system, and the dispersion liquid used 3mol L -1 HCl solution to adjust the pH to 1.2, at 20000r·min -1 Centrifuge for 10 min, add 0.1% Poloxamer (w / v) to the precipitate to redisperse, and use 1mol L -1 The NaOH s...

Embodiment 3

[0041] Example 3: Preparation and Application of Paclitaxel Monoglyceride Nanostructured Carrier Delivery System

[0042] 1) Preparation of paclitaxel monoglyceride nanostructure carrier drug delivery system

[0043] Take 60 mg of monoglyceride and 3 mg of paclitaxel respectively, weigh them accurately, add 6 mL of absolute ethanol, and dissolve in a water bath at 70°C. Take distilled water as the dispersed phase, put it in a water bath at 70°C, and set it at 400r·min -1 Under the condition of mechanical stirring, the organic phase was injected into 60mL of the dispersed phase, and stirred for 5min to obtain the dispersion liquid of paclitaxel monoglyceride nanostructured lipid carrier drug delivery system, and the dispersion liquid used 3mol L -1 HCl solution to adjust the pH to 1.2, at 20000r·min -1 Centrifuge for 10 min, add 0.1% Poloxamer (w / v) to the precipitate to redisperse, and use 1mol L -1 NaOH solution was used to adjust the pH to 7.0 to obtain the paclitaxel mon...

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Abstract

The invention discloses an application of nanometer structure lipid carrier administration system in the antineoplastic drug to reverse the multiple-drug tolerance of tumour cell, which comprises the following parts: solid lipid material, liquid lipid material and antineoplastic drug, wherein the rate of the liquid lipid (such as oleic acid) is 0-30wt%; the solid lipid is selected from monoglyceride; the liquid lipid is oleic acid; the antineoplastic drug is Paclitaxel or adriablastina. The invention has highly effective cell uptaking and cytolymph condensing function with packing molecular target in the antineoplastic drug of cell, which avoids P-glucoprotein in the drug tolerant cytolymph from identifying the antineoplastic drug to reduce exclusion.

Description

technical field [0001] The invention relates to the application of the nanostructure lipid carrier delivery system, and mainly relates to the application of the nanostructure lipid carrier delivery system in anti-tumor treatment and reversal of tumor multidrug resistance. Background technique [0002] Tumor has always been a major disease that directly threatens human health. Due to the lack of molecular targeting of drugs themselves, tumor chemotherapy has major treatment problems such as low cure rate, multidrug resistance, and huge toxic and side effects. One of the important reasons for the failure of clinical chemotherapy is the resistance of tumor cells to chemotherapy drugs. The cause of death of most cancer patients is directly or indirectly related to the resistance of tumor cells to anti-tumor drugs. Therefore, finding and studying drug delivery systems that can reverse the drug resistance of drug-resistant tumor cells is one of the important strategies and direct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/14A61K31/704A61K31/337A61K47/12A61P35/00
Inventor 胡富强杜永忠袁弘游剑
Owner ZHEJIANG UNIV
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