Injectable compound bone cement and preparation method thereof

A technology of bone cement and calcium phosphate bone cement, applied in the field of injectable composite bone cement kit, injectable composite bone cement and its preparation, to achieve the effects of high compressive strength, excellent anti-collapse performance and excellent injection performance

Active Publication Date: 2012-07-04
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this co-modification method needs to add a variety of additives at the same time to improve the different proper

Method used

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  • Injectable compound bone cement and preparation method thereof
  • Injectable compound bone cement and preparation method thereof
  • Injectable compound bone cement and preparation method thereof

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[0113] Preparation method of injectable composite bone cement

[0114] In a preferred embodiment, the preparation method of the injectable composite bone cement provided by the present invention comprises the following steps:

[0115] (1) Chitosan microspheres and calcium phosphate bone cement powder are mixed evenly;

[0116] (2) Add a solidifying solution containing sodium glycerophosphate (GP), and mix evenly to obtain an injectable composite bone cement.

[0117] In a preferred embodiment, the preparation method of the injectable composite bone cement provided by the present invention comprises the following steps:

[0118] (1) chitosan microspheres are mixed evenly with the solidified solution containing sodium glycerophosphate,

[0119] (2) Add calcium phosphate bone cement powder and mix evenly to obtain an injectable composite bone cement.

[0120] In another preferred example, the weight ratio of the calcium phosphate bone cement powder to the cross-linked chitosan...

Embodiment 1

[0131] Preparation of sulfuric acid cross-linked chitosan

[0132] Dissolve chitosan in acetic acid solution, prepare 3% (w / v) chitosan solution, add slowly in the oil phase liquid paraffin containing emulsifier, stir to form W / O emulsion, add 20% (w / v) v) Sulfuric acid solution is cross-linked to form sulfuric acid cross-linked chitosan microspheres, then fully washed with acetone, absolute ethanol and water, and freeze-dried to obtain chitosan microspheres with complete morphology and smooth and compact surface (Such as figure 1 shown), the particle size is 5-20 μm.

Embodiment 2

[0134] Preparation of phosphoric acid cross-linked chitosan

[0135] Dissolve chitosan in acetic acid solution, prepare 1% (w / v) chitosan solution, and drop it into NaOH-methanol mixed solution under high-voltage static electricity to coagulate, collect microspheres, and then disperse the microspheres Treat in a phosphoric acid solution with a concentration of 30% (w / v) for 20 hours; collect the microspheres, wash and dry them fully to obtain phosphoric acid cross-linked chitosan microspheres, and the particle size of the microspheres is 80-120 μm.

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Abstract

The invention discloses injectable compound bone cement and a preparation method thereof. The invention further discloses a kit for preparing the injectable compound bone cement. The kit comprises solid powder and a curing liquid, wherein the solid powder comprises calcium phosphate bone cement powder and chitosan microspheres; and the curing liquid contains glycerophosphate. The injectable compound bone cement is prepared by uniformly mixing the solid power with the curing liquid, has superior scattering resistance, superior injection performance, rapid self-curing performance, high compressive strength and high biocompatibility, and can be used for preparing a biomedical material applied to bone defect reconstruction, bone fracture treatment and bone repair.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to an injectable composite bone cement kit, an injectable composite bone cement and a preparation method and application thereof. Background technique [0002] With the development of minimally invasive procedures, such as percutaneous surgery, there is an increasing need for directly injectable biomaterials. Since its cured product is similar to the inorganic phase of natural bone, self-curing calcium phosphate cement (CPC) can be used as a minimally invasive surgical material for repairing bone defects. However, some shortcomings of injectable calcium phosphate bone cement, such as poor mechanical properties, difficulty in injection, easy collapse in blood or liquid, and lack of holes for bone cell growth, have limited its wide clinical application. [0003] In order to overcome these shortcomings, people use different kinds of additives to improve the performance ...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/12C08J3/24
Inventor 刘昌胜钱秀珍王靖
Owner EAST CHINA UNIV OF SCI & TECH
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