Compound bone cement, preparation method and application of compound bone cement, and bone repair material

A bone cement and bone repair technology, applied in the field of preparation, bone repair materials, and composite bone cement, can solve the problems of calcium phosphate bone cement application limitations, insufficient compressive strength, and easy collapse, so as to promote chondrocyte differentiation and expand Range of use, effect of improving collapse resistance

Active Publication Date: 2018-07-13
深圳市中科海世御生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the existing calcium phosphate bone cement still has obvious deficiencies, for example, it is prone to collapse when it contacts body fluids in the early stage of setting, and its compressive strength is not enough to be used for the repair of load-bearing bone defects.
At the same time, because the final solidification product of calcium phosphate bone cement in the body is hydroxyapatite (HA), and the degradation rate of hydroxyapatite is extremely slow, and it cannot release osteoinductive elements, so it does not have osteoinductive properties. The above defects make phosphoric acid The application of calcium bone cement is limited to some extent

Method used

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  • Compound bone cement, preparation method and application of compound bone cement, and bone repair material
  • Compound bone cement, preparation method and application of compound bone cement, and bone repair material
  • Compound bone cement, preparation method and application of compound bone cement, and bone repair material

Examples

Experimental program
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Effect test

Embodiment 1

[0043] This embodiment provides a composite bone cement, which is prepared by mixing raw materials including 80% solid phase powder and 20% solidification liquid by mass percentage. The solid phase powder is composed of anhydrous calcium hydrogen phosphate: tetracalcium phosphate according to 30%:70% mass percentage is uniformly mixed and prepared, and the solidified liquid is uniformly prepared from citric acid: chitosan: hyaluronic acid: water according to the mass percentage of 20%: 20%: 10%: 50%.

[0044] This embodiment also provides a method for preparing the above-mentioned composite bone cement. Anhydrous calcium hydrogen phosphate: tetracalcium phosphate is mixed uniformly according to a mass percentage of 30%: 70% to form a solid phase powder, and citric acid is added to deionized water to form Citric acid solution, then chitosan and hyaluronic acid are added to the citric acid solution in sequence and mixed uniformly to prepare a solidified liquid. The mass ratio of cit...

Embodiment 2

[0047] Take anhydrous calcium hydrogen phosphate: tetracalcium phosphate according to the mass percentage of 70%: 30% to mix uniformly to prepare a solid phase powder, take citric acid and add deionized water to form a citric acid solution, and then add chitosan to the citric acid solution in sequence It is uniformly mixed with hyaluronic acid to prepare a solidified liquid, and the mass ratio of citric acid: chitosan: hyaluronic acid: water in the solidified liquid is 5%: 5%: 1%: 89%. At room temperature, the solid phase powder and the solidified liquid are respectively 50%: 50%, 60%: 40%, 66.7%: 33.3%, 75%: 25% and 80%: 20% by mass percentages (that is, mass ratios respectively) (1:1, 1.5:1, 2:1, 3:1 and 4:1) were mixed for 2 minutes to prepare 5 kinds of uncured composite bone cements.

[0048] Take the above five uncured composite bone cements, and use a medical syringe to characterize the injectability of the composite bone cement. The specific process is: accurately weigh t...

Embodiment 3

[0050] Take anhydrous calcium hydrogen phosphate: tetracalcium phosphate according to the mass percentage of 40%:60% to mix uniformly to prepare a solid phase powder, take acetic acid and add deionized water to form an acetic acid solution, and then add chitosan and hyaluronic acid to the acetic acid solution. The acid is mixed uniformly to prepare a solidified liquid, and the mass ratio of acetic acid: chitosan: hyaluronic acid: water in the solidified liquid is 15%: 15%: 5%: 65%. At room temperature, the solid-phase powder and the solidified liquid were mixed at a mass percentage of 80%:20% for 1 minute to prepare an uncured composite bone cement.

[0051] Experimental group: The uncured composite bone cement was filled into a mold with a diameter of 6 mm and a height of 12 mm, cured at 37 degrees Celsius for 24 hours, and then demolded to obtain a bone repair material.

[0052] Control group: Take the solid phase powder of the same composition and deionized water, mix them at a ...

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Abstract

The invention discloses compound bone cement, a preparation method and application of the compound bone cement, and a bone repair material. The compound bone cement is prepared by mixing the followingraw materials in percentage by mass: 50-80% of solid phase powder and 20-50% of setting liquid, wherein the solid phase powder comprises phosphate and/or acidic salt of phosphoric acid; the setting liquid comprises chitosan, hyaluronic acid, organic acids and water. The compound bone cement has excellent syringeability, biological activity and bone conduction and repair ability, the set bond repair material has an excellent mechanical property, the surface of the material is easy for cell adhesion, and the cell differentiation ability cannot be influenced. The compound bone cement disclosed by the invention can be used for bone defect filling and repairing and serves as a drug carrier to be used for treating orthopedic related diseases.

Description

Technical field [0001] The invention relates to the field of biomaterials, in particular to a composite bone cement, a preparation method and application thereof, and a bone repair material. Background technique [0002] Bone cement is a kind of medical material widely used in orthopedic surgery. Bone cement is usually composed of solid powder and solidifying liquid. It can be solidified by mixing it in a certain proportion at room temperature. Place it in a joint replacement or filling After the reaction is over, the joint can be fixed or the bone defect can be repaired. Because bone cement is injectable, it can minimize the area of ​​minor surgical wounds, accelerate the speed of recovery, and reduce the pain of patients. Therefore, the filling materials and scaffold materials commonly used in bone tissue play a supporting role and are indispensable for bone tissue applications. A member of. Since the advent of bone cements in the early 1960s, the main types of bone cements h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/12A61L27/54A61L27/50A61L27/58A61K31/7036A61K38/14A61K31/496A61P19/08A61P31/04
CPCA61K31/496A61K31/7036A61K38/14A61L27/12A61L27/20A61L27/50A61L27/54A61L27/58A61L2300/204A61L2300/252A61L2300/41A61L2300/412A61L2300/602A61L2400/06A61L2430/02C08L5/08
Inventor 崔旭潘浩波王践云黄程程杨鸿生张朦
Owner 深圳市中科海世御生物科技有限公司
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