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Preparing process of magnetic adsorbent and its application in treating hyperbilirubinemia

A magnetic adsorbent and magnetic technology, applied in the field of biomedical materials, can solve problems such as blood vessel blockage, poor compatibility, and particle shedding

Inactive Publication Date: 2007-06-27
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Excessive bilirubin can be removed by hemoperfusion. The earliest adsorbent used is activated carbon, but its adsorption selectivity is poor, and particles are prone to fall off, leading to blood vessel blockage.
With the development of synthetic polymer materials, people have introduced different functional groups on polymer resins, hoping to improve the adsorption performance of adsorbents for bilirubin, but these adsorbents have poor compatibility with blood.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0013] 1. Preparation of Magnetic Adsorbent

[0014] (1) Preparation of magnetic chitosan polymer microspheres

[0015] Weigh 3.0g chitosan, dissolve it with 150ml 2% acetic acid solution, transfer it into a 500mL reaction vessel, and heat it at 1200r·min -1 Under the conditions of stirring speed and heating in a water bath at 35°C, add 50mL 0.5mol / L ferric ammonium sulfate solution and 50mL 0.5mol / L ferrous ammonium sulfate solution, then immediately add 1mol / L sodium hydroxide solution, and stir until the solution It is black and bright in color, moved into an ultrasonic cleaner, and ultrasonically oscillated for the purpose of dispersing magnetic chitosan polymer microspheres. In the ultrasonic solution, add 2.5mL cross-linking agent epichlorohydrin, and continue to stir the reaction, so that the cross-linking reaction between epichlorohydrin and the hydroxyl group in chitosan can fully occur, and then precipitate with the help of a magnetic field, and wash repeatedly with...

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PUM

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Abstract

The present invention discloses preparation process and application in treating hyperbilirubinemia of magnetic adsorbent. The magnetic adsorbent is one kind of polyaminated magnetic chitosan microsphere prepared with (NH4)2Fe(SO4)2.6H2O, NH4Fe(SO4)2.12H2O and chitosan as main material, and sodium hydroxide as precipitant, and through hydroxypropylation and amination. It has hydroxypropyl radical and amino radical introduced into the molecular structure of chitosan, high amino radical content, strengthened alkalinity, reactive functional amino radical and capacity of being separated fast under the action of external magnetic field. It has high adsorption on bilirubin and may be used in treating hyperbilirubinemia.

Description

field of invention [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a magnetic adsorbent and its application in treating hyperbilirubinemia. Background technique [0002] Bilirubin is the catabolism product of heme, the prosthetic group of hemoglobin in mammals, and exists in biological fluids such as blood and bile. Many diseases can cause an abnormal increase in the concentration of bilirubin in the blood, resulting in hyperbilirubinemia. Patients with hyperbilirubinology will develop biliary cirrhosis, and other organs will also be yellowed by bilirubin, which will affect their functions and cause other syndromes. Excessive bilirubin can be removed by hemoperfusion. The earliest adsorbent used is activated carbon, but its adsorption selectivity is poor, and particles are prone to fall off, leading to blood vessel blockage. With the development of synthetic polymer materials, people have introduced di...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P1/16A61P43/00
Inventor 王丽娟刘峥覃庆敏
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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