Preparing process of magnetic adsorbent and its application in treating hyperbilirubinemia

Abstract

The present invention discloses preparation process and application in treating hyperbilirubinemia of magnetic adsorbent. The magnetic adsorbent is one kind of polyaminated magnetic chitosan microsphere prepared with (NH4)2Fe(SO4)2.6H2O, NH4Fe(SO4)2.12H2O and chitosan as main material, and sodium hydroxide as precipitant, and through hydroxypropylation and amination. It has hydroxypropyl radical and amino radical introduced into the molecular structure of chitosan, high amino radical content, strengthened alkalinity, reactive functional amino radical and capacity of being separated fast under the action of external magnetic field. It has high adsorption on bilirubin and may be used in treating hyperbilirubinemia.

Description

field of invention

[0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a magnetic adsorbent and its application in treating hyperbilirubinemia. Background technique

[0002] Bilirubin is the catabolism product of heme, the prosthetic group of hemoglobin in mammals, and exists in biological fluids such as blood and bile. Many diseases can cause an abnormal increase in the concentration of bilirubin in the blood, resulting in hyperbilirubinemia. Patients with hyperbilirubinology will develop biliary cirrhosis, and other organs will also be yellowed by bilirubin, which will affect their functions and cause other syndromes. Excessive bilirubin can be removed by hemoperfusion. The earliest adsorbent used is activated carbon, but its adsorption selectivity is poor, and particles are prone to fall off, leading to blood vessel blockage. With the development of synthetic polymer materials, people have introduced di...