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Chitosan microsphere, and preparation method and application thereof

A technology of chitosan microspheres and chitosan, which is applied in the directions of application, pharmaceutical formulation, and medical preparations containing active ingredients, etc., to achieve the effects of promoting healing, good biocompatibility, and simple preparation method.

Active Publication Date: 2016-08-31
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the deepening of research, it is found that there are certain limitations in the chitosan hemostatic material of a single component, therefore, it is necessary to improve the existing chitosan hemostatic material

Method used

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  • Chitosan microsphere, and preparation method and application thereof
  • Chitosan microsphere, and preparation method and application thereof
  • Chitosan microsphere, and preparation method and application thereof

Examples

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preparation example Construction

[0042] The second aspect of the present invention provides a kind of preparation method of chitosan microsphere, comprises the following steps:

[0043] Prepare chitosan solution and hydrophilic polymer solution respectively, hydrophilic polymer comprises at least one in polyvinyl alcohol, gelatin, cellulose and polyethylene oxide, chitosan solution and hydrophilic polymer solution Mixing and mixing to obtain a mixed solution; in the mixed solution, the mass of chitosan and the mass of the hydrophilic polymer account for 25%-99% and 1%-75% of the total mass of the solute respectively;

[0044]The mixed solution is dripped into the negatively charged receiving solution by electrostatic spraying method, and left standing to obtain a suspension of microspheres. After the microspheres are separated and obtained, they are washed and dried to obtain chitosan microspheres, which consist of chitosan and hydrophilic polymer, in the chitosan microsphere, the mass percentage of chitosan ...

Embodiment 1

[0072] A preparation method of chitosan microspheres, comprising the following steps:

[0073] (1) Weigh 3 g of chitosan (CS) and dissolve it in 100 mL of dilute acetic acid to prepare a CS solution with a mass volume concentration of 3% (w / v), and store it at 4°C for future use. Weigh a certain amount of polyvinyl alcohol (PVA), place it in a constant temperature water bath at 70°C and stir until it is completely dissolved, then make a PVA solution with a mass volume concentration of 0.6% (w / v) with water, and store it at 4°C for later use. A certain amount of sodium polyphosphate (TPP) was weighed and dissolved in water to obtain a TPP aqueous solution with a mass volume concentration of 4.5% (w / v);

[0074] (2) get a certain amount of above-mentioned chitosan solution and polyvinyl alcohol solution, fully mix, the mass volume concentration of both chitosan and PVA in the mixed solution is 1.8%, wherein, the mass ratio of chitosan and PVA is 5:1. And set the propulsion spe...

Embodiment 2

[0077] A preparation method of chitosan microspheres, comprising the following steps:

[0078] (1) Weigh 3 g of chitosan (CS) and dissolve it in 100 mL of dilute acetic acid to prepare a CS solution with a mass volume concentration of 3% (w / v), and store it at 4°C for future use. Weigh a certain amount of polyvinyl alcohol (PVA), place it in a constant temperature water bath at 70°C and stir until it is completely dissolved, then make a PVA solution with a mass volume concentration of 0.6% (w / v) with water, and store it at 4°C for later use. A certain amount of sodium polyphosphate (TPP) was weighed and dissolved in water to obtain a TPP aqueous solution with a mass volume concentration of 4.5% (w / v).

[0079] (2) get a certain amount of above-mentioned chitosan solution and polyvinyl alcohol solution, fully mix, the mass volume concentration of both chitosan and PVA in the mixed solution is 1.8%, wherein, the mass ratio of chitosan and PVA It is 5:1. Set the receiving dista...

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Abstract

The invention provides a chitosan microsphere. The chitosan microsphere comprises, by mass, 25-99% of chitosan and 1-75% of a hydrophilic polymer, and the hydrophilic polymer comprises at least one of polyvinyl alcohol, gelatin, cellulose and polyoxyethylene. The chitosan microsphere improves the moisture absorption capability and the moisture retention capability of chitosan, and solves the problem of traditional powder hemostasis materials. The invention also provides a preparation method of the chitosan microsphere. The method comprises the following steps: mixing a chitosan solution with a hydrophilic polymer solution until the chitosan solution and the hydrophilic polymer solution are uniform in order to prepare a mixed solution; and adding the mixed solution to a negatively charged receiving solution in a dropwise manner through adopting an electrostatic spraying technology, standing to obtain a microsphere suspension, separating to obtain microspheres, washing the microspheres, and drying the washed microspheres to obtain the chitosan microsphere. The preparation method has the advantages of simplicity and mild conditions, and the dimensions of the prepared chitosan microsphere are uniform and controllable.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a chitosan microsphere and a preparation method and application thereof. Background technique [0002] Chitosan (CS) is a natural biopolymer polysaccharide derived from the ocean, which has the effect of accelerating hemostasis. At present, the hemostatic mechanism of chitosan has not been clarified, but studies have found that CS has two main functions in the coagulation process: (1) it can effectively promote the activation of platelets to accelerate the coagulation activation process; (2) it can absorb blood through electrostatic force The red blood cells (RBCs) in the blood can enhance the interaction between red blood cells and tissues, so that they can be enriched at the wound, achieve the blocking effect, and achieve the purpose of hemostasis. And it can also activate the coagulation pathway through the activation of platelets, accelerate the synthesis of blood fibrin, st...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00A61L26/00A61K9/16A61K31/722A61P7/04A61P17/02
CPCA61K9/1635A61K9/1641A61K9/1652A61K9/1658A61K31/722A61L24/001A61L24/043A61L26/0023A61L26/0061A61L2400/04C08L5/08
Inventor 赵晓丽陈庆昌刘缘
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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