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Nano-silver-containing sodium alginate based antibacterial medical dressing and preparation method thereof

A technology of sodium alginate and nano-silver, applied in medical science, absorbent pads, bandages, etc., can solve the problems of poor antibacterial performance and wettability, poor air permeability and mechanical properties, and achieve high bactericidal activity and excellent hygroscopic performance , good stability

Active Publication Date: 2013-12-18
哈尔滨生材新材料科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a sodium alginate-based antibacterial agent containing nano-silver in order to solve the problems of poor antibacterial performance and wettability, poor air permeability and mechanical properties in the existing chitosan-based medical dressing and its preparation method. Medical dressing and preparation method thereof

Method used

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Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0026] Specific embodiment 1: A sodium alginate-based antibacterial medical dressing containing nano-silver in this embodiment is made of nano-silver particles and an interpenetrating network film; wherein, the interpenetrating network film is made of sodium alginate and high The molar ratio of nano-silver particles to sodium alginate is 1:10-50; the molar ratio of nano-silver particles to macromolecules is 1-10:60.

[0027] The dressing of this embodiment has undergone a morphology observation test, and the dressing pore size ranges from 100 to 800 microns.

[0028] The dressing in this embodiment has good toughness and can be bent arbitrarily, so as to be suitable for wounds in different parts.

[0029] When the antibacterial medical dressing of this embodiment is in contact with the wound, the released calcium ions can induce the activation of platelets, produce hemostatic growth factors, play the role of hemostasis and accelerate wound healing, quickly and efficiently cont...

specific Embodiment approach 2

[0036] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the polymer is a mixture of gelatin, polyvinyl alcohol or chitosan, or a combination of several combinations in any ratio. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0037] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that the molar ratio of silver nanoparticles to sodium alginate is 1-5:10. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a preparation method of a nano-silver-containing sodium alginate based antibacterial medical dressing, and relates to an antibacterial medical dressing with sodium alginate as a main raw material, solving the problems that the air permeability is poor, the wettability is low, the antibacterial performance is not realized and the like in the existing dressing and a preparation method thereof. The medical dressing provided by the invention is composed of silver nanoparticles, sodium alginate and an interpenetrating polymer network film. The preparation method provided by the invention comprises the following steps: I, preparing nano-silver loaded sol; II, preparing a sodium alginate solution loaded with silver nanoparticles; III, preparing a crosslinked polymer solution; IV, preparing a mixing solution used for processing the dressing; V, preliminarily processing and forming the dressing; and VI, preparing the nano-silver-containing sodium alginate based antibacterial medical dressing. The dressing is able to quickly control major bleeding, has antibacterial performance, is outstanding in moisture absorption performance, high in moisture-vapor transmission and biocompatibility, and biodegradable, has the capacity of promoting wound healing and is low in price, simple and convenient to operate, and suitable for mass production.

Description

technical field [0001] The invention relates to an antibacterial medical dressing with sodium alginate as the main raw material. Background technique [0002] Skin trauma is a common clinical disease. In order to avoid bacterial infection and other external factors, protect and promote wound healing, and promote tissue repair, various wounds and wound surfaces are often temporarily covered with medical dressings. The commonly used clinical dressings are mainly made of gauze, medical absorbent cotton and other materials. Although the cost is low, the source of raw materials is wide, the production is simple, and it has strong absorption capacity, but the hemostatic effect is not good, and the moisturizing effect of the non-invasive surface is easy to cause secondary damage. The accumulation of fluid on the surface can easily cause bacterial infection and so on. [0003] Sodium alginate is a linear anionic natural polysaccharide extracted from seaweed, composed of β-D-mannuro...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/28A61L15/22A61L15/32A61L15/24C08J5/18C08J3/24
Inventor 李莉李兆清李珍郑卫郑玉峰
Owner 哈尔滨生材新材料科技发展有限公司
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