97 results about "Bioresorbable polymers" patented technology

Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.

Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.

A device and method for stabilizing a spine utilizes one or more stabilization members made of, or including, a bioresorbable and / or biointegrable material such as natural tissue or a bioresorbable polymer. The stabilization member(s) may be elastic, and may secure one or more spinal motion segments in a manner effective to reduce the range of flexion and / or extension of the spinal motion segments. The stabilization member may include one or more elongate straps of nonosteogenic natural tissue, each of which may be secured to the spine using fasteners such as bone screws or tacks. The stabilization device may include a blocking member sized and configured to be effective for maintaining a medically desirable distance between adjacent spinous processes in the spine of a medical patient.

A method of making a porous bioresorbable dressing is provided for use in applying reduced pressure therapy to a wound site. The process includes manufacture of a dressing by use of one or more bioresorbable polymers and a porogen system. The malleability of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include use of hand molding and formation of a rope dressing. The porogen system may be activated external to the wound site or formed in situ within the wound site, thus creating a porous dressing. A reduced pressure delivery tube is fluidly connected to the wound site to delivery a reduced pressure to the wound site.

A luminal stent is a tubular body formed by knitting a sole yarn of a bioresorbable polymer fiber, such as fiber of polylactic acid, polyglycol acid or a polylactic acid—polyglycol acid copolymer. When introduced into and attached to the inside of the vessel by a catheter fitted with a balloon, the tubular member may retain its shape for several weeks to several months after attachment and subsequently disappears by being absorbed into the living tissue. In this manner, the luminal stent is not left as a foreign matter semi-permanently in the living body without producing inflammation or hypertrophy in the vessel. There is also provided a method for attaching the luminal stent in the vessel.

Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.

The invention relates to the use of Fused Deposition Modeling to construct three-dimensional (3D) bioresorbable scaffolds from bioresorbable polymers such as polycaprolactone (PCL), or from composites of bioresorbable polymers and ceramics, such as polycaprolactone / hydroxyapatite (PCL / HA). Incorporation of a bioresorbable ceramic to produce a hybrid / composite material support provides the desired degradation and resorption kinetics. Such a composite material improves the biocompatibility and hard tissue integration and allows for increased initial flash spread of serum proteins. The basic resorption products of the composite also avoids the formation of an unfavorable environment for hard tissue cells due to a decreased pH. The scaffolds have applications in tissue engineering, e.g., in tissue engineering bone and cartilage.

Methods and constructs including a fixation device and a suture for fixation of soft tissue to bone, or of soft tissue to soft tissue, which amplifies the body's healing response created by the introduction of the suture material and the material properties of the fixation device. Fixation of soft tissue to bone (or of soft tissue to soft tissue) is conducted using a suture (for example, a suture strand, braid, a suture tape, or a combination thereof) and a fixation device (for example, a bone anchor, implant or screw). The suture and fixation device are manufactured from materials that have properties to amplify the body's healing response. Materials such as synthetic bioresorbable polymers (for example, poly-lactic acid) are utilized in the fabrication of orthopedic fixation devices. Once these materials are introduced into the body and are exposed to in vivo conditions, the devices manufactured with these materials undergo hydrolysis and degrade while maintaining specific mechanical properties over time.

Implantable medical devices and prosthesis for rapid regeneration and replacement of tissues, and methods of making and using the devices, are described. The medical devices include a complex three-dimensional braided scaffold with a polymer composition and structure tailored to desired degradation profiles and mechanical properties. The composite three-dimensional braided scaffolds are braided from yarn bundles of biodegradable and bioresorbable polymeric fibers and / or filaments. Monofilament fibers and / or multifilament fibers can be twisted / plied in different combinations to form multifilament yarns, composite multifilament yarns, or composite yarns. The medical devices are useful as both structural prosthetics taking on the function of the tissue as it regenerates and as in vivo scaffolds for cell attachment and ingrowth.

Bone fixation or augmentation in a mammalian body to enhance the mechanical strength of a fracture is provided by reinforcement fixing bone ends together using the implant device. A resorbable device can be rendered anti-osteolytic by incorporating materials such as bisphosphonates. It can also be rendered osteoconductive by the incorporation of an osteoconductive material such as bioactive glass or TCP. The implant device has a matrix as one phase, where the matrix is made of a bioresorbable polymer. One phase of the implant is made from self-reinforcing elements and the matrix contains an antiosteolytic agent component. The implant contains further osteoconductive and / or osteoconductive material.

The invention relates to the use of Fused Deposition Modeling to construct three-dimensional (3D) bioresorbable scaffolds from bioresorbable polymers such as polycaprolactone (PCL), or from composites of bioresorbable polymers and ceramics, such as polycaprolactone / hydroxyapatite (PCL / HA). Incorporation of a bioresorbable ceramic to produce a hybrid / composite material support provides the desired degradation and resorption kinetics. Such a composite material improves the biocompatibility and hard tissue integration and allows for increased initial flash spread of serum proteins. The basic resorption products of the composite also avoids the formation of an unfavorable environment for hard tissue cells due to a decreased pH. The scaffolds have applications in tissue engineering, e.g., in tissue engineering bone and cartilage.

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and / or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.

Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.

Methods of treating coronary and peripheral artery disease in diabetic patients with bioresorbable polymer stents are described. The stents may include everolimus.

The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.

The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and / or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.

An implant for use in biological / biomedical applications may be prepared by subjecting a substrate to a gas-plasma treatment. The substrate may be a biocompatible material, including metals, ceramics, and polymers. More specifically, the substrate may be a bioresorbable polymer. The gas-plasma treatment may include subjecting the substrate to a plasma formed by a reactive gas. The gas-plasma treatment may be performed for a chosen duration at a radio frequency within a temperature range, a pressure range, and a supplied energy range. The substrate may be exposed to living cells, such that some of the living cells become coupled to the substrate. Gas-plasma treatment parameters may be chosen such that the living cells coupled to the treated substrate produce more of a cellular product than living cells coupled to an untreated substrate.

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.

The present invention provides a safe biodegradable and bioabsorbable polymer having an extremely low metal catalyst content, while retaining the properties desired for a medical implant or the like; and a process for producing the same. The present invention further provides a method for reducing the content of a metal catalyst in a biodegradable and absorbable polymer that can be applied on an industrial scale. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 40 / 60 to 60 / 40 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 25 / 75 to 45 / 55 at less than 40° C., and drying the copolymer. 13. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 65 / 35 to 85 / 15 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 45 / 55 to 55 / 45 at less than 40° C., and drying the copolymer.

The invention provides a neural restoration sleeve and a preparing method and application thereof. The neural restoration sleeve is a double-layer fiber sleeve, the inner layer of the sleeve is an orientation polymer fiber layer, the outer layer of the sleeve is a non-orientation polymer fiber layer, bioresorbable polymers are adopted, and the nerve growth promoting factors are embedded in the inner layer. The neural restoration sleeve prepared through the preparing method can induce nerve cells to grow in the fiber orientation, meanwhile, the nerve growth promoting factors are embedded in the inner layer to promote growth of nerve axon and accelerate nerve tissue restoration, the non-woven non-orientation polymer fiber layer on the outer layer plays a role in supporting and endows the neural restoration sleeve with high strength and stability, and the polymers on the inner layer and the outer layer are the bioresorbable polymers, have high biocompatibility, will not cause chronic inflammation reaction and are high in safety; the preparing method is simple, and industrial production can be realized.

A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. A bioactive agent may therefore be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture comprising an oxidized dextran solution, and a second aliquot portion of a reaction mixture comprising a mixture of solids comprised of a dihydrazide, a bioactive agent, and a solid acid which is present in an amount sufficient to achieve a pH of the reaction mixture of 6 or less, mixing the first and second aliquot portions to form the reaction mixture thereof, and thereafter installing the reaction mixture at the body site and allowing a solidified bioerodible drug delivery composition to be formed thereby in situ. The present invention may be provided in the form of a kit comprised of a double syringe which respectively contains the first and second aliquot portions of the reaction mixture so that the same may be mixed just prior to use.

Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.

A method of laser machining a polymer construct to form a stent that includes a bioresorbable polymer and an absorber that increases absorption of laser energy during laser machining. The laser cuts the tubing at least in part by a multiphoton absorption mechanism and the polymer and absorber have a very low absorbance or are transparent to light at the laser wavelength.

Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

The invention provides a neural restoration sleeve tube and a preparation method and application thereof. The neural restoration sleeve tube is a double-layer fiber sleeve tube, the inner layer of the sleeve tube is an orientated polymer fiber layer, the outer layer of the sleeve tube is a non-woven non-orientated polymer fiber layer, and the polymer is a bioresorbable polymer. According to the neural restoration sleeve tube prepared through the preparation method, nerve cells can grow along the fiber orientation, then nervous tissue is restored, the non-woven non-non-orientated polymer fiber layer on the outer layer achieves a supporting function, and the neural restoration sleeve tube achieves good strength and stability. Meanwhile, due to the fact that the polymer on the inner layer and the outer layer is the bioresorbable polymer, good biocompatibility is achieved, no chronic inflammation reaction is caused, high safety is achieved, the preparation method is simple, and industrial production can be achieved.

The invention relates to a method for preparing a composite material having a homogeneous composition, containing at least one bioactive ceramic phase and at least one bioresorbable polymer. The inventive method is characterised in that it comprises the following steps: a) a bioactive ceramic phase in powder form is obtained, b) the bioactive ceramic powder is suspended in a solvent, c) a bioresorbable polymer is added to the suspension obtained in (b) and mixed to produce a viscous homogeneous dispersion of said bioactive ceramic powder in a solution formed by the solvent and the polymer, and d) the dispersion obtained in (c) is precipitated in an aqueous solution in order to obtain a homogeneous composite material. The invention also relates to the resulting composite material and to the use thereof in the production of implantable medical devices.

The invention provides an absorbable luminal stent and a preparation method thereof. The absorbable luminal stent comprises a stent body, a plurality of through holes prepared on the stent body and bioresorbable polymer materials full filled in the through holes. When the stent is transplanted into a blood vessel, by compounding of the materials in the through holes and the material of the stent body, damage caused in the pressure holding and opening process of the stent is reduced, duration time of a radial supporting force of the stent is prolonged and mechanical performance of the transplanted stent is ensured.

Implantable medical devices and prosthesis for rapid regeneration and replacement of tissues, and methods of making and using the devices, are described. The medical devices include a complex three-dimensional braided scaffold with a polymer composition and structure tailored to desired degradation profiles and mechanical properties. The composite three-dimensional braided scaffolds are braided from yarn bundles of biodegradable and bioresorbable polymeric fibers and / or filaments. Monofilament fibers and / or multifilament fibers can be twisted / plied in different combinations to form multifilament yarns, composite multifilament yarns, or composite yarns. The medical devices are useful as both structural prosthetics taking on the function of the tissue as it regenerates and as in vivo scaffolds for cell attachment and ingrowth.