91 results about "Bioresorbable polymers" patented technology

A device and method for stabilizing a spine utilizes one or more stabilization members made of, or including, a bioresorbable and/or biointegrable material such as natural tissue or a bioresorbable polymer. The stabilization member(s) may be elastic, and may secure one or more spinal motion segments in a manner effective to reduce the range of flexion and/or extension of the spinal motion segments. The stabilization member may include one or more elongate straps of nonosteogenic natural tissue, each of which may be secured to the spine using fasteners such as bone screws or tacks. The stabilization device may include a blocking member sized and configured to be effective for maintaining a medically desirable distance between adjacent spinous processes in the spine of a medical patient.

A luminal stent is a tubular body formed by knitting a sole yarn of a bioresorbable polymer fiber, such as fiber of polylactic acid, polyglycol acid or a polylactic acid—polyglycol acid copolymer. When introduced into and attached to the inside of the vessel by a catheter fitted with a balloon, the tubular member may retain its shape for several weeks to several months after attachment and subsequently disappears by being absorbed into the living tissue. In this manner, the luminal stent is not left as a foreign matter semi-permanently in the living body without producing inflammation or hypertrophy in the vessel. There is also provided a method for attaching the luminal stent in the vessel.

Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.

Methods and constructs including a fixation device and a suture for fixation of soft tissue to bone, or of soft tissue to soft tissue, which amplifies the body's healing response created by the introduction of the suture material and the material properties of the fixation device. Fixation of soft tissue to bone (or of soft tissue to soft tissue) is conducted using a suture (for example, a suture strand, braid, a suture tape, or a combination thereof) and a fixation device (for example, a bone anchor, implant or screw). The suture and fixation device are manufactured from materials that have properties to amplify the body's healing response. Materials such as synthetic bioresorbable polymers (for example, poly-lactic acid) are utilized in the fabrication of orthopedic fixation devices. Once these materials are introduced into the body and are exposed to in vivo conditions, the devices manufactured with these materials undergo hydrolysis and degrade while maintaining specific mechanical properties over time.

Bone fixation or augmentation in a mammalian body to enhance the mechanical strength of a fracture is provided by reinforcement fixing bone ends together using the implant device. A resorbable device can be rendered anti-osteolytic by incorporating materials such as bisphosphonates. It can also be rendered osteoconductive by the incorporation of an osteoconductive material such as bioactive glass or TCP. The implant device has a matrix as one phase, where the matrix is made of a bioresorbable polymer. One phase of the implant is made from self-reinforcing elements and the matrix contains an antiosteolytic agent component. The implant contains further osteoconductive and/or osteoconductive material.

The invention relates to the use of Fused Deposition Modeling to construct three-dimensional (3D) bioresorbable scaffolds from bioresorbable polymers such as polycaprolactone (PCL), or from composites of bioresorbable polymers and ceramics, such as polycaprolactone/hydroxyapatite (PCL/HA). Incorporation of a bioresorbable ceramic to produce a hybrid/composite material support provides the desired degradation and resorption kinetics. Such a composite material improves the biocompatibility and hard tissue integration and allows for increased initial flash spread of serum proteins. The basic resorption products of the composite also avoids the formation of an unfavorable environment for hard tissue cells due to a decreased pH. The scaffolds have applications in tissue engineering, e.g., in tissue engineering bone and cartilage.

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.

Methods of treating coronary and peripheral artery disease in diabetic patients with bioresorbable polymer stents are described. The stents may include everolimus.

The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.

The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.

The invention provides a neural restoration sleeve and a preparing method and application thereof. The neural restoration sleeve is a double-layer fiber sleeve, the inner layer of the sleeve is an orientation polymer fiber layer, the outer layer of the sleeve is a non-orientation polymer fiber layer, bioresorbable polymers are adopted, and the nerve growth promoting factors are embedded in the inner layer. The neural restoration sleeve prepared through the preparing method can induce nerve cells to grow in the fiber orientation, meanwhile, the nerve growth promoting factors are embedded in the inner layer to promote growth of nerve axon and accelerate nerve tissue restoration, the non-woven non-orientation polymer fiber layer on the outer layer plays a role in supporting and endows the neural restoration sleeve with high strength and stability, and the polymers on the inner layer and the outer layer are the bioresorbable polymers, have high biocompatibility, will not cause chronic inflammation reaction and are high in safety; the preparing method is simple, and industrial production can be realized.

Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

The invention provides a neural restoration sleeve tube and a preparation method and application thereof. The neural restoration sleeve tube is a double-layer fiber sleeve tube, the inner layer of the sleeve tube is an orientated polymer fiber layer, the outer layer of the sleeve tube is a non-woven non-orientated polymer fiber layer, and the polymer is a bioresorbable polymer. According to the neural restoration sleeve tube prepared through the preparation method, nerve cells can grow along the fiber orientation, then nervous tissue is restored, the non-woven non-non-orientated polymer fiber layer on the outer layer achieves a supporting function, and the neural restoration sleeve tube achieves good strength and stability. Meanwhile, due to the fact that the polymer on the inner layer and the outer layer is the bioresorbable polymer, good biocompatibility is achieved, no chronic inflammation reaction is caused, high safety is achieved, the preparation method is simple, and industrial production can be achieved.

The invention relates to a method for preparing a composite material having a homogeneous composition, containing at least one bioactive ceramic phase and at least one bioresorbable polymer. The inventive method is characterised in that it comprises the following steps: a) a bioactive ceramic phase in powder form is obtained, b) the bioactive ceramic powder is suspended in a solvent, c) a bioresorbable polymer is added to the suspension obtained in (b) and mixed to produce a viscous homogeneous dispersion of said bioactive ceramic powder in a solution formed by the solvent and the polymer, and d) the dispersion obtained in (c) is precipitated in an aqueous solution in order to obtain a homogeneous composite material. The invention also relates to the resulting composite material and to the use thereof in the production of implantable medical devices.

The invention provides an absorbable luminal stent and a preparation method thereof. The absorbable luminal stent comprises a stent body, a plurality of through holes prepared on the stent body and bioresorbable polymer materials full filled in the through holes. When the stent is transplanted into a blood vessel, by compounding of the materials in the through holes and the material of the stent body, damage caused in the pressure holding and opening process of the stent is reduced, duration time of a radial supporting force of the stent is prolonged and mechanical performance of the transplanted stent is ensured.

A bioresorbable polymer is obtained by reacting together (a) a prepolymer comprising co-polymerised units of a caprolactone and poly(alkylene oxide) moieties; (b) a polycaprolactone diol comprising co-polymerised units of a caprolactone and a C₂-C₆ diol; and (c) a diisocyanate. The polymer may be loaded with a pharmaceutically active agent to produce a drug delivery device.

New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles