The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The
assembly can include a depot having a therapeutic region comprising a therapeutic agent, and a control region comprising a bioresorbable
polymer and a releasing agent mixed with the
polymer. The releasing agent may be configured to dissolve when the depot is placed
in vivo to form
diffusion openings in the control region. The depot may be configured to be implanted at a treatment site
in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.