Neural restoration sleeve tube and preparation method and application thereof

A nerve repair and cannula technology, applied in the field of nerve cannula, can solve the problems of nerve compression, difficulty in use, and difficulty in batch production of natural protein, and achieve good strength and stability, good biocompatibility, and easy operation Effect

Inactive Publication Date: 2016-04-06
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Natural materials that can be used as nerve sleeves include blood vessels, denatured muscle, laminin, fibronectin, collagen, etc. Natural materials can sometimes cause adverse immune reactions, although immunosuppressants can play a role, but in injury or In the case of tumors, it is not easy to use; in addition, natural proteins are difficult to mass-produce, and the quality and performance are difficult to control. People have turned more attention to artificial materials
Non-degradable artificial material sleeves include silicone sleeves and polytetrafluoroethylene sleeves. The simple use of such sleeves has no e...

Method used

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  • Neural restoration sleeve tube and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] In this embodiment, the nerve repair sleeve is prepared by the following method, which specifically includes the following steps:

[0043] (1) Dissolve polycaprolactone in a mixture of chloroform and N,N-dimethylformamide at a volume ratio of 1:1 to prepare a solution with a mass volume concentration of 30%, and then stir at 50°C 24h obtains polymer solution;

[0044] (2) The polymer solution is injected into the electrospinning equipment through a syringe (with a No. 5 stainless steel needle, 1-5mm in diameter) for spinning. The parameters during spinning are set as follows: the spinneret voltage is 10kV, and the solution flow rate is 5mL / h; the formed fiber is ejected from the spinneret of the electrospinning equipment, the receiving distance between the receiving device and the spinneret is 5cm, the receiving device is equipped with double electrodes as the receiving electrodes, and the axes of the double electrodes are parallel on the same horizontal line permutat...

Embodiment 2

[0046] In this embodiment, the nerve repair sleeve is prepared by the following method, which specifically includes the following steps:

[0047] (1) Glycolide-lactide copolymer (glycolide content greater than 80%) is dissolved in a mixture of chloroform and N,N-dimethylformamide with a volume ratio of 2:1 to prepare A solution with a mass volume concentration of 10%, and then stirred at 60° C. for 20 hours to obtain a polymer solution;

[0048] (2) The polymer solution is injected into the electrospinning equipment through a syringe (with a No. 5 stainless steel needle, 1-5mm in diameter) for spinning. The parameters during spinning are set as follows: the spinneret voltage is 20kV, and the solution flow rate is 3mL / h; the formed fiber is ejected from the spinneret of the electrospinning equipment, the receiving distance between the receiving device and the spinneret is 10cm, the receiving device is equipped with double electrodes as the receiving electrodes, and the axes of...

Embodiment 3

[0050] In this embodiment, the nerve repair sleeve is prepared by the following method, which specifically includes the following steps:

[0051] (1) Dissolving caprolactone-glycolide copolymer (caprolactone content greater than 70%) in a mixture of chloroform and N,N-dimethylformamide with a volume ratio of 3:1 is prepared A solution with a mass volume concentration of 1%, and then stirred at 80° C. for 12 hours to obtain a polymer solution;

[0052] (2) The polymer solution is injected into the electrospinning equipment through a syringe (with a No. 5 stainless steel needle, 1-5mm in diameter) for spinning. The parameters during spinning are set as follows: the spinneret voltage is 30kV, and the solution flow rate is 1mL / h; the formed fiber is ejected from the spinneret of the electrospinning equipment, the receiving distance between the receiving device and the spinneret is 25cm, the receiving device is equipped with double electrodes as the receiving electrodes, and the a...

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Abstract

The invention provides a neural restoration sleeve tube and a preparation method and application thereof. The neural restoration sleeve tube is a double-layer fiber sleeve tube, the inner layer of the sleeve tube is an orientated polymer fiber layer, the outer layer of the sleeve tube is a non-woven non-orientated polymer fiber layer, and the polymer is a bioresorbable polymer. According to the neural restoration sleeve tube prepared through the preparation method, nerve cells can grow along the fiber orientation, then nervous tissue is restored, the non-woven non-non-orientated polymer fiber layer on the outer layer achieves a supporting function, and the neural restoration sleeve tube achieves good strength and stability. Meanwhile, due to the fact that the polymer on the inner layer and the outer layer is the bioresorbable polymer, good biocompatibility is achieved, no chronic inflammation reaction is caused, high safety is achieved, the preparation method is simple, and industrial production can be achieved.

Description

technical field [0001] The invention belongs to the technical field of nerve sleeves, and relates to a nerve repair sleeve, a preparation method and application thereof. Background technique [0002] Peripheral nerve injury is a disease often encountered in clinical work, which can lead to loss of sensation and motor dysfunction. Since nerve cells do not divide, their growth is impenetrable, making regeneration in the body very difficult. At present, various intervention strategies such as tissue or cell transplantation, tissue and bioengineering, electromagnetic and other physical factors, nerve stimulation or regulation, drugs or chemicals are used to promote the regeneration, repair and reconstruction of destroyed or damaged nerves on the basis of the original nerve anatomy and function. Modeling and reconstructing neuroanatomical projection pathways and circuits, regulating and improving nerve signal conduction can all partially achieve neurological function restoration...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/26A61L27/18A61L27/58
CPCA61F2/02A61L27/18A61L27/26A61L27/58A61L31/041A61L31/06C08L67/04C08L67/00C08L69/00C08L61/00
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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