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Porous bioresorbable dressing conformable to a wound and methods of making same

a bioresorbable and porous technology, applied in the field of porous bioresorbable dressings, can solve the problems of difficult to obtain a proper width, length or depth of the dressing to properly fit the wound, the rate limiting step of wound healing is often angiogenesis, and the wound is often chronic, so as to achieve the effect of convenient conformation

Inactive Publication Date: 2008-05-15
KCI LICENSING INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides methods, systems, and compositions for making bioresorbable dressings that can be used in reduced pressure therapy for wound healing. The dressings are designed to conform to the size and shape of the wound site and can be made in various ways, such as by dissolving a polymer in a solvent and mixing it with a porogen, or by placing a porous bioresorbable dressing in a fluid that reacts with the porogen to create pores within the dressing. The resulting dressing can be hand molded or shaped into a rope and placed in the wound to fit its shape and size. A reduced pressure delivery tube is connected to the dressing to deliver reduced pressure to the wound site. The invention also provides methods for making the dressing with factors to promote tissue growth and healing, such as cells or growth factors.

Problems solved by technology

The rate limiting step of wound healing, however, is often angiogenesis.
Impairments in wound angiogenesis therefore may lead to chronic problem wounds.
While use of reduced pressure therapy with the dressing has been highly successful, there still exists various difficulties with this process.
For example, it may be difficult to obtain a dressing of a proper width, length or depth to properly fit the wound.
Further, as the dressing is removed it may also remove healthy tissue, thereby causing further trauma to the wound site.
Individual wounds, however, are of inconsistent shapes and sizes.

Method used

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  • Porous bioresorbable dressing conformable to a wound and methods of making same
  • Porous bioresorbable dressing conformable to a wound and methods of making same
  • Porous bioresorbable dressing conformable to a wound and methods of making same

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first embodiment

[0026] The first embodiment in accordance with the invention is to a method and apparatus for preparing a bioresorbable porous polymer dressing and use of the dressing with reduced pressure therapy, as illustrated in FIG. 1.

[0027] To start, one or more bioresorbable polymers is dissolved in an appropriate solvent (101). The type of solvent used will depend upon the bioresorbable polymer(s) selected. The bioresorbable polymer is a biocompatible material whose degradation by products can be bio assimilated or excreted via natural pathways in the body. The bioresorbable polymer may include, but is not limited to, lactide, poly(lactide) (PLA), glycolide polymers, poly(glycolic acid) (PGA), poly(lactide-co-glycolide) (PLGA), ethylene glycol / lactide copolymers, polycaprolactone, polyhydroxybutyrate, polyurethanes, polyphosphazenes, poly(ethylene glycol)-poly(lactide-co-glycolide) co-polymer, polyhydroxyacids, polycarbonates, polyamides, polyanhydrides, polyamino acids, polyortho esters, p...

second embodiment

[0039] The second embodiment in accordance with the invention is to a method and apparatus for preparing a bioresorbable porous polymer dressing and use of the porous dressing for reduced pressure therapy, as illustrated in FIG. 2.

[0040] A bioresorbable polymer is dissolved in an appropriate solvent (201). The bioresorbable polymer may be made of one or more polymers that are bioresorbable. Suitable polymer include those polymers disclosed in other embodiments of the invention. In an alternate embodiment, one or more plasticizers are also added to the bioresorbable polymer.

[0041] The bioresorbable polymer is then mixed with a crystalline or solid salt that serves as the porogen system (202). The invention is not limited by the type of salt, as long as the salt is of an appropriate particle size and dissolvable in a fluid, i.e., a gas, liquid, or flowable material, including but not limited to, colloids, dressings, a liquid, a slurry, a suspension, a viscous gel, a paste, a putty, a...

third embodiment

[0053] The third embodiment in accordance with the invention is to a method and apparatus for preparing a bioresorbable porous polymer dressing and use of the dressing for reduced pressure therapy, as illustrated in FIG. 3.

[0054] One or more bioresorbable polymers are dissolved in an appropriate solvent (301). Suitable bioresorbable polymers may include any polymers discussed in other embodiments of the invention. In one alternative embodiment, at least one plasticizer is also added to the bioresorbable polymer.

[0055] The bioresorbable polymer is then mixed with a porogen system, which may include one or more compounds that result in creation of pores within the dressing. (302). The type of a porogen system is not limited, and may include compounds that dissolve when placed in contact with a fluid. This type of porogen system includes inorganic salts like sodium chloride, crystals of saccharose, or gelatin spheres will dissolve in fluids such as water. Another type of porogen syste...

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Abstract

A method of making a porous bioresorbable dressing is provided for use in applying reduced pressure therapy to a wound site. The process includes manufacture of a dressing by use of one or more bioresorbable polymers and a porogen system. The malleability of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include use of hand molding and formation of a rope dressing. The porogen system may be activated external to the wound site or formed in situ within the wound site, thus creating a porous dressing. A reduced pressure delivery tube is fluidly connected to the wound site to delivery a reduced pressure to the wound site.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 60 / 857,903, filed Nov. 9, 2006, U.S. Provisional Application No. 60 / 857,902, filed Nov. 9, 2006, and U.S. Provisional Application No. 60 / 857,814, filed Nov. 9, 2006. Priority is claimed to all of the above-mentioned applications, and each application is hereby incorporated by reference.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention relates generally to methods, systems and compositions for making and using porous bioresorbable dressing in various configurations. [0004] 2. Description of Related Art [0005] Wound healing may be broadly split into three overlapping basic phases: inflammation, proliferation, and maturation. The inflammatory phase is characterized by hemostasis and inflammation. The next phase consists mainly of epithelialization, angiogenesis, granulation tissue formation, and collagen deposition. The final pha...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F13/00
CPCA61F13/00987A61F2013/00536A61F2013/00927Y10T156/1005A61L15/64A61M1/0023A61L15/425A61P17/02A61M1/915A61F13/02
Inventor AMBROSIO, ARCHELPAYNE, JOANNAKIESWETTER, KRISTINE
Owner KCI LICENSING INC
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