Neural restoration sleeve and preparing method and application thereof

Abstract

The invention provides a neural restoration sleeve and a preparing method and application thereof. The neural restoration sleeve is a double-layer fiber sleeve, the inner layer of the sleeve is an orientation polymer fiber layer, the outer layer of the sleeve is a non-orientation polymer fiber layer, bioresorbable polymers are adopted, and the nerve growth promoting factors are embedded in the inner layer. The neural restoration sleeve prepared through the preparing method can induce nerve cells to grow in the fiber orientation, meanwhile, the nerve growth promoting factors are embedded in the inner layer to promote growth of nerve axon and accelerate nerve tissue restoration, the non-woven non-orientation polymer fiber layer on the outer layer plays a role in supporting and endows the neural restoration sleeve with high strength and stability, and the polymers on the inner layer and the outer layer are the bioresorbable polymers, have high biocompatibility, will not cause chronic inflammation reaction and are high in safety; the preparing method is simple, and industrial production can be realized.

Description

technical field [0001] The invention belongs to the technical field of nerve sleeves, and relates to a nerve repair sleeve, a preparation method and application thereof. Background technique [0002] Peripheral nerve injury is a disease often encountered in clinical work, which can lead to loss of sensation and motor dysfunction. Since nerve cells do not divide, their growth is impenetrable, making regeneration in the body very difficult. At present, various intervention strategies such as tissue or cell transplantation, tissue and bioengineering, electromagnetic and other physical factors, nerve stimulation or regulation, drugs or chemicals are used to promote the regeneration, repair and reconstruction of destroyed or damaged nerves on the basis of the original nerve anatomy and function. Modeling and reconstructing neuroanatomical projection pathways and circuits, regulating and improving nerve signal conduction can all partially achieve neurological function restoration...

AI Technical Summary

Problems solved by technology

Natural materials that can be used as nerve sleeves include blood vessels, denatured muscle, laminin, fibronectin, collagen, etc. Natural materials can sometimes cause adverse immune reactions, although immunosuppressants can play a role, but in injury or In the case of tumors, it is not easy to use; in addition, natural proteins are difficult to mass-produce, and the quality and performance are difficult to control. People have turned more attention to artificial materials

Non-degradable artificial material sleeves include silicone sleeves and polytetrafluoroethylene sleeves. The simple use of such sleeves has no effect on nerve axon regeneration, and these sleeves will remain in the form of foreign bodies after implanted in the human body. Human body, prone to chronic inflammatory response, excessive scar tissue formation can lead to nerve compression, and in severe cases, a second operation is required to remove the cannula

Absorbable artificial materials have good biological properties, and some degradable materials can promote better growth of nerve cells. However, their induced behavior is not directional, and their strength and shape are not easy to maintain for a long time after implantation, which limits their clinical use.

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