Medicine eluted cardiovascular support
A cardiovascular and drug technology, applied in the field of balloon-expandable stents, can solve the problems of complex preparation technology and unfavorable promotion and use, and achieve the effects of promoting healing, overcoming intolerance to body fluid washout, and preventing late thrombosis
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Embodiment 1
[0032] Preparation of biodegradable materials:
[0033] Weigh 70 parts of L-lactide, 5 parts of glycolide and 25 parts of ε-caprolactone in a dry polymerization bottle with a stirring bar, and use N 2Replaced 3 times, placed in an oil bath at 160°C, after melting, added a certain volume of 0.02g / ml stannous octoate chloroform solution (catalyst amount is 0.02wt% of monomer mass), removed chloroform under reduced pressure, and reacted under stirring After 5h, the polymer was dissolved with chloroform and precipitated with ethanol. The molecular weight of the obtained polymer was characterized by gel permeation chromatography (GPC), and the molecular weight was greater than 100,000.
Embodiment 2
[0035] Preparation of heparinized poly(lactic-glycolic acid-amino acids):
[0036] Weigh 0.1mol L-lactide and 0.05mol morpholine dione derivative monomer containing benzyloxy-protected glutamic acid in a dry polymerization bottle with a stirring bar, and use N 2 Replace 3 times, place in 160°C oil bath, after melting, add a certain volume of 0.02g / ml stannous octoate chloroform solution, remove chloroform under reduced pressure, react for 5h under stirring, dissolve polymer with chloroform, and precipitate with ethanol. The obtained polymer is de-benzyloxyl grouped with Pd / C catalyst and hydrogen gas bubbling for 40 to obtain poly(lactic acid-glycolic acid-glutamic acid).
[0037] Heparin contains amino groups and carboxyl groups. Dissolve poly(lactic acid-glycolic acid-aspartic acid) in a mixed solvent of tetrahydrofuran and water, dissolve heparin sodium in a small amount of water, and adjust the pH to about 4 with dilute acid. Mix the two, add an equivalent amount of dicyc...
Embodiment 3
[0039] Dissolve 0.1 gram of heparinized poly(lactic acid-glycolic acid-amino acid), 0.1 gram of anti-restenosis drug rhubarb and 0.1 gram of rapamycin (Rampamycin) in 5 ml of chloroform, and then immerse the balloon-expandable stent in the solution About 30s, take it out and blow dry for later use. The stent can overcome restenosis in the stent and prevent the formation of acute and subacute thrombus. Meanwhile, the heparin has an anti-inflammation effect, can inhibit the foreign body inflammatory reaction of the stent, and promote the healing of the wound on the inner wall of the blood vessel.
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