Metal implant material with controllable corrosion and degradation and its application

An implant material and metal technology, applied in the field of biomedical metal implant materials, can solve the problems of loss of strength, low hardness and rigidity, poor degradation controllability, etc., to reduce volume and quality, ensure mechanical properties, and good degradation cycle Effect

Inactive Publication Date: 2006-11-08
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, most of the degradable materials used in medicine are polymer materials. The degradable polymer materials have the following problems: 1. Low strength, low hardness and rigidity; 2. Poor degradation controllability, degradation time is not proportional to strength and rigidity, degradation During the process, it is easy to lose strength prematurely and cause the device to fail early; 3. The accumulation of local acidic degradation products affects healing; 4. The processing stability is poor, and the processing of degraded polymer materials requires special processing environments and equipment; 5. Sterilization and disinfection The performance will change and decrease during the process; 6. The storage stability is poor, and the degradation during the storage process is inevitable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Pure magnesium (99.95%, average grain size: 32 μm) is used to make a coronary stent sample (after polishing, the wire diameter is 70-80 μm), and the service time of the stent needs to be 6 months to one year according to the usual clinical requirements. The stent was ultrasonically cleaned in alcohol for 5 minutes, dried, and soaked in the simulated plasma solution prepared according to Table 1. After about 7 months, it was completely corroded and degraded, and the average corrosion rate was between 0.1-0.12mm / year.

Embodiment 2

[0021] Cast pure magnesium (99.5%, average grain size: 257μm, size: 19.6mm×25.7mm×2.0mm) is polished, ultrasonically cleaned in alcohol for 5 minutes, dried, and soaked in 0.9% NaCl solution One month, the average corrosion degradation rate calculated according to the weight loss is: 1.31mm / year, and it is estimated that it will take about one and a half years for the entire sample to fully degrade.

Embodiment 3

[0023] After forging, pure magnesium (99.95%, average grain size: 62μm, size: 18.9mm×22.6mm×1.76mm) is polished, ultrasonically cleaned in alcohol for 5 minutes, dried, and soaked in 0.9% NaCl solution One month, the average corrosion degradation rate calculated according to the weight loss is: 0.42mm / year, and it is estimated that it will take about two to three years for the entire sample to degrade completely.

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PUM

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Abstract

The present invention relates to biomedicine metal implant material, and is especially metal implant material with controllable erosion and degrading rate and its application. The metal implant material with controllable erosion and degrading rate is magnesium or magnesium alloy with poor anticorrosive property. The metal implant material with controllable erosion and degrading rate of magnesium or magnesium alloy may be used in preparing temporary or short term implanted device, such as degradable blood rack and peripheral rack, bone fracture plate and bone nail for inner fixing, tissue engineering rack, etc.

Description

technical field [0001] The invention relates to biomedical metal implant materials, in particular to controllable corrosion degradation metal implant materials and applications thereof. Background technique [0002] At present, most of the degradable materials used in medicine are polymer materials. The degradable polymer materials have the following problems: 1. Low strength, low hardness and rigidity; 2. Poor degradation controllability, degradation time is not proportional to strength and rigidity, degradation During the process, it is easy to lose strength prematurely and cause the device to fail early; 3. The accumulation of local acidic degradation products affects healing; 4. The processing stability is poor, and the processing of degraded polymer materials requires special processing environments and equipment; 5. Sterilization and disinfection The performance will change and decrease during the process; 6. The storage stability is poor, and the degradation during th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L27/04A61L29/02A61L33/02
Inventor 任伊宾黄晶晶杨柯张炳春杨惠宾
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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