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Locally enhanced nickel-titanium alloy intracranial stent

A nickel-titanium alloy and local reinforcement technology, applied in the field of medical devices, can solve problems such as poor expansion, poor adherence, and collapse of stents, improve stability and support strength, prevent poor expansion or collapse, and reduce the possibility of displacement Effect

Inactive Publication Date: 2020-02-21
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for complex intracranial aneurysms, such as: huge, wide neck, fusiform, dissection, perforating vessels, etc., interventional treatment is still very difficult; existing products are difficult to coordinate flexibility and support performance, and those with high stiffness The overall stent is hard, and the wall-attachment is poor after implantation, which can easily lead to excessive endothelial hyperplasia
Stents with good compliance often have insufficient support performance, and there are complications such as stent displacement, poor stent expansion, and collapse when placed in complex lesions.

Method used

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  • Locally enhanced nickel-titanium alloy intracranial stent
  • Locally enhanced nickel-titanium alloy intracranial stent
  • Locally enhanced nickel-titanium alloy intracranial stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Such as Figure 2(a)-Figure 2(d) As shown, in this embodiment, three kinds of central enhanced intracranial stents are designed, the span of the single diamond-shaped unit is designed to be 8mm, and the ratios of the single diamond-shaped unit to the surface area of ​​the entire intracranial stent are adjusted to 8.3%, 16.7% and 33.3%, respectively, and A simple double diamond unit design scaffold was used as a control. The length of the intracranial stent is 22.5mm, the outer diameter is 4.43mm, and the wall thickness of the intracranial stent is 0.8mm. The wire width of the sine wave structure of the intracranial stent is 0.05mm, the width of the connecting rod is 0.05mm, and the height of the connecting rod is 0.045mm. The ratio of the height dimension to the width dimension of the single rhombus unit is 1.03. The three-point bending process and extrusion process of the bracket are simulated by finite element method.

[0041] As shown in Figure 3, the finite elemen...

Embodiment 2

[0043] Example 2 The designed stent has a length of 22.5 mm, an outer diameter of 4.43 mm, and a wall thickness of the intracranial stent of 0.8 mm. The intracranial stent is uniformly enhanced. According to the simulation results in Example 1, when the proportion of single diamond-shaped units is between 16.7% and 33.3%, the bracket has better flexibility and supporting performance. Therefore, in this embodiment, the effect of the uniform reinforcement design is verified by adopting a design method in which the area of ​​a single diamond-shaped unit accounts for 20% of the entire surface area of ​​the stent. The wire width of the sine wave structure of the intracranial stent is 0.05 mm, the width of the connecting rod is 0.05 mm, and the height of the connecting rod is 0.05 mm. The ratio of the height dimension to the width dimension of the single rhombus unit is 1.03.

[0044] Such as Figure 4(a)-Figure 4(b) As shown, the final intracranial stent can be obtained after la...

Embodiment 3

[0047] Example 3 Design intracranial stents with different wire widths. The wire widths of the sine wave structure of the intracranial stent are 0.025mm, 0.05mm and 0.075mm respectively, the wall thickness of the intracranial stent is 0.85mm, and the width of the connecting rod is 0.05mm. The height is 0.05mm. The ratio of the height dimension to the width dimension of the single rhombus unit is 1.5.

[0048] Some stents were selected for radial compression simulation to explore the influence of different wire widths on the support performance of the stent. The results show that the radial forces of the four kinds of stents are: 0.009N·mm -1 (0.025mm wire width), 0.015N·mm -1 (0.05mm wire width), 0.021N·mm -1 (0.075mm wire width). The radial support force increases with the increase of wire width, see Image 6 .

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Abstract

The invention relates to a locally enhanced nickel-titanium alloy intracranial stent, and belongs to the field of medical equipment. The intracranial stent can be used for assisting coil embolizationto treat intracranial aneurysms. An intracranial stent main body has a tubular structure formed by using single rhombus units composed of sine wave structures and connecting rods and double rhombus units each formed by combining two single rhombus units. The double rhombus units can improve the flexibility of the stent, and the single rhombus structures can guarantee the stability and supporting performance of the stent to a certain extent; and in addition, by adjusting the position and number of different-shape units, a plurality of stent structures can be designed and changed to achieve different mechanical characteristics. According to the locally enhanced nickel-titanium alloy intracranial stent design based on the mixed unit structure, an optimized unit ratio can be designed in different use environments, supporting enhancement at specific positions (such as a tumor path opening) can be realized on the premise that compliance of the stent is guaranteed, and the stent can be used for assisting the coil embolization.

Description

technical field [0001] The invention relates to a partially reinforced nickel-titanium alloy intracranial stent, which can be used to assist coil embolization in treating intracranial aneurysms, and belongs to the field of medical devices. Background technique [0002] Intracranial aneurysm is the abnormal bulging of cerebral blood vessels caused by hypertension, atherosclerosis, potential vascular lesions, trauma, infection, tumors, etc. It is also the primary cause of hemorrhagic cerebrovascular diseases. With the continuous innovation of intravascular interventional materials and the continuous development of related technologies, the treatment of intracranial aneurysms has become simpler and safer, and more intracranial aneurysms can be completely embolized through interventional methods. However, for complex intracranial aneurysms, such as: huge, wide neck, fusiform, dissection, perforating vessels, etc., interventional treatment is still very difficult; existing produc...

Claims

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Application Information

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IPC IPC(8): A61B17/12
CPCA61B17/12031A61B17/12118A61B17/12168
Inventor 张兴郭峰燕阳阳杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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