The invention provides a multifunctional
coating of a
biodegradable polymer stent and a preparation method thereof. An innermost
coating layer is prepared from an anticoagulation
drug and a
drug carrier (
water soluble chitosan and a cross-linking agent
genipin); a middle
coating layer is prepared from a
cell proliferation resistant fat soluble
drug and a
drug carrier (
polymer PLCL and a cross-linking agent HDI); and the outermost coating layer is prepared from an anticoagulation drug, an endothelialization enhancement drug and a
drug carrier (
water soluble chitosan and a cross-linking agent
genipin), and the outermost coating layer is only prepared on the inner side of the
stent. The preparation method adopts a dip-coating method to prepare the coating, the technology is simple, the requirement to the equipment is low, the prepared three-layered drug carrying
polymer coating can achieve
time sequence release of different drugs, reduces formation of
thrombus at the early stage and the later stage, promotes endothelialization, inhibits proliferation of
smooth muscle cells, and decreases the in-
stent restenosis, meanwhile, the middle layer of
elastomer coating completes wraps the stent body, the damage of the stent after being pressed and held and expanded is reduced, and the radial supporting property of the stent is improved.