81results about How to "Improve radial support" patented technology

The invention provides a cobalt-chromium alloy artery stent with full-biodegradation medicine coating; the full-biodegradation coating of the stent has good stent flexibility, pathological change permeability and radial bearing force; the invention further provides a preparation method of the stent; multi-level coating applying technology, metallic support surface inert gas processing process and the like are adopted, the firmness of the stent surface coating, the toughness and tensile strength thereof are greatly improved, thereby being beneficial to keeping the integrity of the coating; in addition, the invention provides a cobalt-chromium alloy artery stent with full-biodegradation medicine coating, which is prepared by radial grading squeezing process, the damage of the coating can be avoided to the greatest extent, the retention force between the stent and a conveying system is greatly improved, the possibility that the stent is migrated in the conveying process is avoided, the clinical using risk is reduced, and the problems of coronary artery stenosis and restenosis are effectively solved.

The invention relates to the field of medical devices, and more specifically discloses a biodegradable stent based on a modified polylactic acid or a polylactic acid copolymer, and a preparation method thereof. According to the present invention, a linear polylactic acid or polylactic acid copolymer with a high molecular weight is blended with a biodegradable cross-linking agent, injection extrusion, injection molding or other processing methods are adopted to prepare a pipe material, the pipe material is subjected to a cross-linking polymerization reaction to form a semi-interpenetrating polymer network, and finally laser cutting is adopted to obtain the stent. The stent has characteristics of sufficient mechanical strength, sufficient structural stability, and improved processability.

The invention relates to a woven artificial trachea and a preparation method thereof, the woven artificial trachea comprises a tube blank and elastic filaments, the tube wall structure of the tube blank is a two-layer woven structure which comprises an inner wall structure and an outer wall structure, a spiral cavity is formed between the inner wall and the outer wall by using a tying and a separating organizational structure at an interval along the axial direction of the tube blank, and then the elastic filaments are inserted into the spiral cavity; and the preparation comprises the following steps: adopting multifilaments and/or single filaments as raw materials, adopting a double-layer tubular organization constituted by a base organization with not more than 6 warp threads according to different motion rules in organization cycles, using the tying and the separating organization at the interval along the axial direction, weaving the tube blank which forms the spiral cavity between the inner wall and the outer wall and penetrating the elastic filaments into the spiral cavity. The woven artificial trachea can improve the radial support performance of the woven artificial trachea, increase the closeness, lead the post-finishing process step to be simple, lead the inner wall to be smooth and be conductive to discharge wastes in the trachea; and the preparation method is simple and applicable to industrial production.

The invention provides a textile-based enhanced degradable tube cavity support and a preparation method and application thereof. The textile-based enhanced degradable tube cavity support is characterized by comprising a hollow tubular fabric formed by two-dimensionally and three-directionally knitting degradable macromolecular silk yarns as knitting silk yarns, wherein axial silk yarns are introduced between two groups of knitting silk yarns in the knitting process and are not knitted, the axial silk yarns are molten through a heat treatment process, weaving points of the two groups of degradable macromolecular silk yarns are bonded and fixed through the molten axial silk yarns, and accordingly the textile-based enhanced degradable tube cavity support stable in shape is obtained. The shortcoming that the edge knitted by a machine is easy to loosen and a structure is not easy to fix can be effectively overcome, slippage of the weaving points of the support can be effectively prevented, the number of the weaving points per unit length when the support is radially compressed is increased, and the radial supporting force of the support is increased.

The invention discloses a vascular stent. Multiple unit rings are arranged to form a tubular structure, wherein the unit rings comprise the first unit rings and the second unit rings, the area formed by each first unit ring in an enclosing mode is smaller than that formed by each second unit ring in an enclosing mode, and the first unit rings and the second unit rings are arranged in a spaced and staggered mode. The first unit rings and the second unit rings have a central point symmetry structure, the vascular stent presents a tubular stent after being unfolded, and included angles are axially formed between the first unit rings and the second unit rings and the tubular stent. According to the vascular stent, the net-shaped structure is formed by arranging the two kinds of unit rings with the different sizes in the spaced mode, high radial support force is achieved, and therefore the flexibility and the expansion property of the stent can be greatly enhanced; in addition, by designing the inclination angles of the two kinds of unit rings, the flexibility and the expansion property of the stent are further enhanced, and it is guaranteed that the force borne by the stent is effectively transmitted in the direction of a stent rod.

The invention discloses a degradable luminal stent with a thermal adhesive composite structure, and a preparation method thereof and application thereof as a mechanically expanded implantable woven stent against stenotic disease. The stent is made of a hollow tubular stent preforming body composed of woven yarn and degradable macromolecular silk yarn through a heat treatment process, shell yarn ismolten in the braided yarn, fusion flowing occurs at interweaving points of two groups of woven yarn, the interweaving points are bonded, and non-interweaving points of the woven yarn form the complete coating for core yarn through softening, fusion and viscose flow. The preparation method includes the steps of making the shell yarn and the core yarn into the woven yarn which is of a shell core structure, the woven yarn and the degradable macromolecular silk yarn are made into the tubular stent preforming body; and after undergoing heat treatment, the tubular stent preforming body forms the degradable luminal stent with the thermal adhesive composite structure. According to the degradable luminal stent, the interweaving points of the stent are regularly bonded and woven, so that the slippage of the interweaving points is limited, the number of the interweaving points in unit length is kept when the stent is subjected to the effect of a radial external force, and thus the radial support force of the stent is improved.

The invention relates to an intracranial sirolimus medicament-release blood vessel stent. The blood vessel stent has an integral net tubular structure which is formed by a cobalt-chromium alloy L605 tube through laser engraving and cutting and electrochemical polishing treatment; the net tubular structure comprises a plurality of support rods with sine waveform unit structures and connecting rods connected among the support rods; and the blood vessel stent is integrally coated with a sirolimus medicament-release layer. A preparation method for the blood vessel stent comprises the following steps: preparing the cobalt-chromium alloy L605 tube into the blood vessel stent of the net tubular structure through laser engraving and cutting and electrochemical polishing treatment; pre-treating the surface of the blood vessel stent of the net tubular structure; preparing sirolimus medicament coating solution; compositely spraying the sirolimus medicament solution to the surface of the blood vessel stent; and drying the sirolimus medicament-release blood vessel stent. The blood vessel stent has low nominal pressure, can effectively inhibit the neointimal formation of the blood vessel and the proliferation and migration of smooth muscle cells (SMC), and also can effectively solve the problem of intracranial arterial blood vessel restenosis.

The invention belongs to the technical field of cross of medicine and engineering and relates to an in-situ laser pulse artery opening device and application thereof. The in-situ laser pulse artery opening device comprises aorta covered stents including the Valiant stent, the zenith flex stent, the Ankura chest aorta covered stent and the chimney stent and a laser. According to the in-situ laser pulse artery opening device, after the aorta covered stents are released, according to the blood vessel condition, the aorta covered stents corresponding to branch blood vessels can be opened through the laser, and the covered stents or bare stents are planted into the opened branch blood vessels to rebuild blood flows of the branch blood vessels and reduce occurrence of relevant complications. According to the in-situ laser pulse artery opening device, the covered stents of standard specifications are adopted, no anatomical structure is destroyed, a stent system does not need to be customized independently according to the individual special anatomical form, and the in-situ laser pulse artery opening device can be used for treating aortic aneurysm or aortic dissection diseases.

The invention relates to an adjustable single-branch man-made aortic arch implant which comprises an aortic arch main stent that is formed by serially connecting nickel-titanium alloy wire materials with a Z-shaped ripple shape; a hollow stent made of a nickel-titanium alloy tube forms a branch blood vessel stent on the aortic arch which is coated by medical tectorial membrane materials; the ripple density of the remote end of the main stent is increased for strengthening the radial support force of the stent, and the Z-shaped ripple at the close end of the main stent is connected with the traditional decron-made artificial blood vessel. The implant of the invention can be squeezed to deform at will in the low temperature, and the host blood vessel can be implanted easily as the caliber can be adjusted at will. In the clinic, not only the aortic arch surgical operation can be simplified, but also the operation time and the surgery complication are reduced, thereby pains of a patient suffered from the aortic arch disease can be lightened more effectively, and the structure is simple as well as the operation is convenient.

The present invention provides a vertebral artery stent and a manufacturing method thereof. The vertebral artery stent includes a plurality of first unit ring structures, a plurality of second unit ring structures and a plurality of connection structures, wherein: a plurality of the first unit The ring structure and the multiple second unit ring structures are axially arranged; the connection structure connects the multiple first unit ring structures and the multiple second unit ring structures, so that the multiple first unit ring structures structure and a plurality of the second unit ring structures form a net columnar structure; the mesh area formed between the adjacent first unit ring structures is smaller than the network formed between the adjacent second unit ring structures Hole area; each of the connecting structures includes a straight connecting rod arranged along the axial direction of the columnar structure, and an "S"-shaped structure connected with the straight connecting rod. The invention solves the problem that the existing support for vertebral artery fails to have high radial support force, flexibility and fatigue resistance.

The present invention provides a blood vessel support. Said support is made up by engraving an elastic metal tube material, it includes several net rings which are arranged along axial direction and are formed from prismatic basic units, between every two adjacent net rings they are connected by means of several Y-shaped connecting pieces.

The invention relates to a high-compliance thoracic aorta covered stent as well as a sizing mould and a sizing method thereof. The high-compliance thoracic aorta covered stent comprises a coating material and a metallic framework, wherein the coating material attaches to the surface of the metallic framework, so that a tubular structure is formed; the coating material is also fixedly connected with the metallic framework by means of medical sutures; the metallic framework comprises a plurality of W-shaped support rings and screw-type support rings, wherein each screw-type support ring is positioned between every two adjacent W-shaped support rings, and the two ends of each screw-type support ring are respectively and fixedly connected with the every two adjacent W-shaped support rings; one end of the coating material is provided with a W-shaped uncoated stent, and the two ends of the coating material are respectively provided with a development mark. The high-compliance thoracic aorta covered stent is used for interventional therapy of thoracic aortic dissection and thoracic aortic aneurysm, and can improve the compliance of a stent main body; after being implanted into the aorta, the stent can better adapt to the form of the aorta, is better in wall adherence, and can reduce complications such as internal leakage and stent-derived new wound which are caused by stent implantation.

The invention discloses a vascular stent construction method based on modularization. The method comprises the following steps of S1, carrying out statistics on vascular stent data, taking vascular stents as modules, and building a stent module database; S2, obtaining lesion blood vessel data, and partitioning the lesion blood vessel; S3, selecting the stent module matched with each partition fromthe stent module database according to the size and lesion condition of each partition of the lesion blood vessel; S4, adjusting models of the stent modules according to the connection conditions ofthe partitions, and determining connection positions and splicing modes of the stent modules of the partitions; and S5, combining the stent modules of the partitions according to the connection positions and the splicing modes of the stent modules of the partitions to complete the construction of a vascular stent. The stent is flexibly adjusted to be combined with high freedom degree and high matching degree, the treatment efficiency is improved, a lantern ring type connecting structure is adopted, a non-overlapping connecting structure is stable, the breakage risk is relatively low, and the service life of the vascular stent is relatively long.

The invention provides a multifunctional coating of a biodegradable polymer stent and a preparation method thereof. An innermost coating layer is prepared from an anticoagulation drug and a drug carrier (water soluble chitosan and a cross-linking agent genipin); a middle coating layer is prepared from a cell proliferation resistant fat soluble drug and a drug carrier (polymer PLCL and a cross-linking agent HDI); and the outermost coating layer is prepared from an anticoagulation drug, an endothelialization enhancement drug and a drug carrier (water soluble chitosan and a cross-linking agent genipin), and the outermost coating layer is only prepared on the inner side of the stent. The preparation method adopts a dip-coating method to prepare the coating, the technology is simple, the requirement to the equipment is low, the prepared three-layered drug carrying polymer coating can achieve time sequence release of different drugs, reduces formation of thrombus at the early stage and the later stage, promotes endothelialization, inhibits proliferation of smooth muscle cells, and decreases the in-stent restenosis, meanwhile, the middle layer of elastomer coating completes wraps the stent body, the damage of the stent after being pressed and held and expanded is reduced, and the radial supporting property of the stent is improved.

The invention discloses a variable radial support force optimization method of an artificial interventional aortic valve stent. The optimization method belongs to the technical field of artificial interventional aortic valve stent optimization. The method specifically comprises the following steps of: optimizing a support grid structure, optimizing a support rib structure and optimizing a supportmaterial. The optimization method is simple in principle, does not change the overall size of an original stent, inherits the core design concept and method of the original stent, optimizes the radialsupporting force of a non-lesion region on the basis of the treatment effect of the original stent on the lesion region, and can select a diversified optimization scheme according to different practical application scenes, thereby solving a practical problem from multiple angles by using multiple schemes. Meanwhile, the optimization method has higher feasibility. The invention provides scientificand reasonable design thoughts and research and development directions for scientific research workers engaged in artificial interventional aortic valve stent design, shortens the research and development period and improves the research and development benefit.

The invention discloses a multi-electrode renal artery radio-frequency ablation catheter. The multi-electrode renal artery radio-frequency ablation catheter comprises an adjusting assembly for adjusting the nerve, a conveying part for conveying the adjusting assembly to the position of the nerve, and a sheath tube, wherein the adjusting assembly comprises a plurality of electrodes for transmitting the adjusting energy to the nerve, and a bearing part for bearing the plurality of electrodes; the bearing part has a first shape and a second shape, and under the first shape, the adjusting assembly is suitable for moving in the blood vessel; under the second shape, at least one electrode is at the position suitable for transmitting the adjusting energy to the nerve. The sheath tube sleeves the conveying part, can slide along the conveying part, and sleeves or is separated from the adjusting assembly. A guide wire channel is arranged inside the multi-electrode renal artery radio-frequency ablation catheter, and the guide wire channel passes through the whole multi-electrode renal artery radio-frequency ablation catheter. Through the independent effect of the sheath tube or a guide wire or through the combined effects of the sheath tube and the guide wire, the bearing part can be switched between the first shape and the second shape.

The invention discloses a heart valve stent and a prosthesis thereof. The stent comprises a stent frame; the stent frame comprises multiple mutually connected grids; two ends of the stent frame are provided with multiple end grids; at least one end grid is a first end grid; all the end grids at the end, where the first end grid is located, are continuously and completely distributed in the circumferential direction; and the projection height of the first end grid in the axial direction is lower than the projection heights of other end grids at the same end in the axial direction. According to the heart valve stent and the prosthesis thereof provided by the invention, damage to a conduction system can be reduced; conduction retardation can be reduced; the operation safety can be improved; and the life quality of a patient can be improved.

The invention discloses a double-layer embolectomy device which comprises an inner-layer net, an outer-layer net and a blocking net structure. The inner-layer net comprises a near-end and a far-end. The head end of the outer-layer net is connected with the near end of the inner-layer net; the grid unit density of the inner-layer net is greater than that of the outer-layer net; one end of the blocking net structure is connected with the tail end of the outer-layer net, and the other end of the blocking net structure is folded and connected with the far-end of the inner-layer net; and the blocking net structure is connected with the outer-layer net to form a network structure wrapping the inner-layer net. When the double-layer embolectomy device is used, the density degree of the blocking net structure can be determined according to the hardness degree of actual thrombus, the proper blocking net structure is selected, and therefore the thrombus capturing success rate is effectively increased, and the phenomenon that part of thrombus is broken, falls off and escapes is prevented; through special grid arrangement of the inner-layer net and the outer-layer net, the compliance and the supporting force of the double-layer embolectomy device are effectively balanced, the damage to blood vessels is reduced, and the thrombus capture capacity is further improved.

The invention belongs to the technical field of biological materials and in particular provides a method for improving usability of a biomedical degradable magnesium alloy cardiovascular stent. The method is characterized by comprising the following steps of: firstly pre-press-holding the magnesium alloy cardiovascular stent until the diameter is 1.05-1.25 times the finally press-holding diameter, then carrying out full annealing treatment on the stent, treating the surface of the stent or coating a drug-loading coating after annealing treatment, then continuing press-holding the stent till the preset dimension so that the stent is closely attached to a sacculus and carrying out subsequent packaging and sterilizing. The method has the beneficial effects that the maximum stress of the press-holding expansion process, the residual stress of the stent after press-holding expansion and expansion resilience can be reduced by introducing the annealing process; the stress safety of the stent and the implantation success rate can be improved by reducing the maximum stress; by reducing the residual stress, the stress corrosion tendency and degradation rate of the stent are reduced and the supporting time of the stent is prolonged; and by reducing expansion resilience, the attachment properties of the stent and blood vessels are improved and the probability of vascular restenosis caused by stent implantation is reduced.