50 results about "Vagal stimulation" patented technology

A soaking device and methods of using are used to cool and / or to heat a face of a person for a purpose of inducing a desired and / or intended outcome in that person. The cooling and / or the heating of the face may be sufficient to induce the desired and / or the intended outcome in that person. The desired and / or intended outcome may relate to: release of at least one type of neurotransmitter; trigeminal nerve stimulation; (indirect) vagus nerve stimulation; transdermal drug delivery; bypass of the blood-brain-barrier (BBB); aesthetic medicine; cardiovascular; dermatological; ears, nose, and throat (otolaryngological); ophthalmological; neurological; psychological; endocrinological; and / or rheumatological benefits to that person. At least one step of the method may include receiving at least some of the face within an immersion-liquid for at least a minimum amount of time while the immersion-liquid is within a temperature-range and while the immersion-liquid is within the soaking device.

The invention relates to a closed-loop vagus nerve intervention control system combined with meditation treatment, and the system comprises a physiological signal collection module which is used for collecting an EEG (electroencephalogram) signal and an ECG (electrocardiosignal) signal of a patient in real time; the data processing and analyzing unit is used for calculating heart-brain and brain-heart bidirectional coupling coefficients on the basis of the acquired signal data and evaluating the execution control function indexes of the patient in real time; the stimulation parameter regulation and control module is used for dynamically adjusting the frequency, the pulse width and the current intensity of the transaural vagus nerve stimulation taVNS according to the calculated bidirectional coupling coefficient; the meditation guidance module is used for providing personalized meditation guidance based on the real-time heart and brain state; the feedback control module is connected with the stimulation parameter regulation and control module and the meditation guidance module and is used for realizing collaborative optimization of stimulation parameters and meditation intervention through a closed-loop adaptive mechanism; and the execution control evaluation module is connected with the feedback control module and is used for improving the risk decision-making capability of the system for joint meditation treatment by setting a plurality of task evaluation modes.

The invention discloses an ear nerve stimulator, and belongs to the technical field of biomedical engineering and nerve regulation and control. The device mainly comprises a plurality of flexible patches attached to the ear, ear electrodes arranged according to ear acupuncture points and embedded in the flexible patches, and a stimulator adopting a cross-ear design. And the flexible patch has biocompatibility and adhesion, so that comfortable and stable wearing is ensured. A control unit and a stimulation module are contained in the stimulator shell, and stimulation current parameters can be generated and accurately regulated and controlled. Through flexible fitting and precise acupoint electrode design, the defects that a traditional electrode is uncomfortable to wear, and a stimulation area is fixed and inaccurate are overcome. And the equipment is light and stable due to the ear-crossing structure. A selectable air pump and air bag mechanism further ensures the reliability of electric contact. The device can realize safe, accurate and comfortable ear vagus nerve stimulation, is suitable for treatment and rehabilitation of epilepsy, depression and other diseases, and has a wide application prospect.

Described herein are a method and a device for noninvasive stimulation of the Vagus nerve. The device is a multichannel device configured to provide non-invasive alternating stimulation of the left and right ear branches of the Vagus nerve as well as acupuncture points of the earlobes using various waveforms. Advantageously, the waveforms are designed to prevent acquired tolerance of the Vagus nerve stimulation thereby creating more effective treatments for a patient.

A non-invasive vagus nerve stimulation apparatus comprising a pair of headphones, a vagus nerve stimulator; one or more cardiac and / or brain activity sensors; and a controller; wherein the pair of headphones includes a pair of spaced apart ear-covering portions and a headband which connects the spaced apart ear-covering portions; the vagus nerve stimulator is carried by one of the ear-covering portions and includes a first arm which carries a cathode and a second arm which carries an anode; the or each cardiac and / or brain activity sensor senses activity within the body of a user and signals relating to the cardiac and / or brain activity are transmitted from the or each electrical activity sensor to the controller; and wherein the controller is carried by the pair of headphones, processes the signals relating to the sensed cardiac and / or brain activity and controls the vagus nerve stimulator to electrically stimulate the vagus nerve.

Provided are wearable transcutaneous auricular vagus nerve stimulation (taVNS) devices. In certain embodiments, a taVNS of the present disclosure comprises a housing comprising a cavity adapted to receive an electrode component. The device may further comprise an electrode component removably embedded in the cavity and comprising two or more electrodes 5 adapted to contact one or more auricular target regions of a subject when wearing the taVNS device, wherein the electrodes are adapted to transcutaneously stimulate an auricular vagus nerve of the subject. In some instances, the device further comprises a behind-the-ear stabilizer adapted to stabilize contact between the two or more electrodes and the one or more auricular target regions of the 10 subject. Also provided are methods of using the devices of the present disclosure, e.g., for clinical and non-clinical purposes in a subject in need thereof.

A taVNS system (100) includes an electrode support (110), a conchae electrode and a conchae cavity electrode (120, 130) attached to and protruding from the electrode support (110) configured to contact skin in the conchae and the conchae cavity, respectively, of an ear of a human subject. A resilient headband (140) is attached to the electrode support (110) and is configured to, when attached to the head of the human subject, apply pressure on the electrode support (110) to press the conchae and conchae electrodes (120, 130) against the skin in the conchae and conchae of the ear of the human subject.

The invention relates to a control work efficiency closed-loop enhancement method and device based on brain cognitive load, and belongs to the technical field of electroencephalogram monitoring and vagus nerve stimulation, and the method comprises the steps: collecting original electroencephalogram signals of a forehead area FP1 / FP2 in real time, and carrying out band-pass filtering and segmentation processing to obtain electroencephalogram data in a data frame form; calculating a phase amplitude coupling index of two brain wave frequency bands according to a theta brain wave and gamma brain wave instantaneous amplitude sequence calculated by Hilbert transform; calculating a brain cognitive load index for evaluating a brain cognitive load state based on the phase amplitude coupling index; according to the brain cognitive load index, dynamically adjusting stimulation pulse parameters to perform vagus nerve stimulation; the brain cognition load is reduced, and the control work efficiency is enhanced; the silent period window with the set duration is reserved after the stimulation pulse is emitted, electroencephalogram data collection is only carried out outside the window, and interference of stimulation artifacts on electroencephalogram signals is avoided. According to the invention, nerve connection can be efficiently improved, and the control efficiency is improved.

The invention relates to a neck vagus nerve stimulation device. The neck vagus nerve stimulation device comprises a base body part which is provided with an opening and is in a semi-surrounding shape and an electrical stimulation unit arranged in the base body part. The base body part is configured to be capable of enlarging the opening so that the opening can penetrate through the neck of the human body, and the opening is narrowed so that the base body part can be clamped to the neck of the human body. The electrical stimulation unit is used for generating electrical pulses and comprises at least one pair of electrodes. The at least one pair of electrodes is arranged on the inner side face of the base body part, the inner side face of the base body part is close to the neck skin, and the electrodes are used for being attached to the neck skin through the elastic restoring force of the base body part when the base body part is clamped on the neck of the human body so as to output electric pulses to stimulate the vagus nerves of the neck. The neck clamping type neck vagus nerve stimulation device is stable and comfortable to wear, reliable in electrode contact, small in limitation on activity of a user and convenient to use at home in daily life.

The invention provides a portable vagus nerve stimulation treatment device and a use method thereof, and the device comprises an ear stimulation assembly which is used for stimulating the vagus nerve of the ear of a patient; the acquisition module is used for acquiring the intensity of a sympathetic nerve signal of the patient; and the host is used for controlling stimulation parameters of the ear stimulation assembly according to the intensity of the sympathetic nerve signal. The ear sympathetic nerves of a patient can be stimulated through the device, and then the patient is treated.

Methods and apparatuses for treating a senescence related disease, disorder, or pathological condition. These methods may include identifying a cellular senescence status in a senescence related disease, disorder, or pathological condition in a subject; and treating the subject for the senescence-related disease, disorder, or conditional by vagal nerve stimulation.

The invention relates to a neck vagus nerve stimulation device and a preparation method thereof. The neck vagus nerve stimulation device comprises a shell, an electrical stimulation unit and a functional application. The electrical stimulation unit comprises a pulse generation module and an electrode connected with the pulse generation module, and at least the electrode is arranged on the shell. The functional patch is arranged on the shell, and the functional patch contains a release substance capable of generating a physiological effect or a sensory effect on a human body. Wherein the shell is suitable for being attached to the neck skin of a human body, so that the electrodes and the functional application are in contact with the neck skin, and the electrical stimulation signals and the release substances jointly act on the human body. The neck vagus nerve stimulation device is compact in structure, portable, easy to use, low in cost and capable of enhancing the treatment effect.

An example system includes a first lead configured to be positioned in or beside a left internal jugular vein (IJV) of a patient to deliver a first stimulation signal to a first vagus nerve, the first lead including one or more first segmented electrodes positioned on a distal portion of the first lead and a first anchoring mechanism; a second lead configured to be positioned in or beside a right IJV of the patient to deliver a second stimulation signal to a second vagus nerve, the second lead including one or more second segmented electrodes positioned on a distal portion of the second lead and a second anchoring mechanism; and circuitry configured to deliver electrical energy to the first lead to deliver the first stimulation signal and the second lead to deliver the second stimulation signal to provide bilateral stimulation to the first vagus nerve and the second vagus nerve.

A method of improving glycemic control is provided. The method includes stimulating a cutaneous distribution of a subject's vagus nerve within the subject's ear with a nerve stimulating signal. The method also includes monitoring the subject's blood glucose. The method further includes administering insulin infusions to the subject.

The invention relates to a neck vagus nerve stimulation device and a preparation method thereof. The neck vagus nerve stimulation device comprises a base body, an electrical stimulation unit and a drug delivery application. The electrical stimulation unit comprises a pulse generation module and an electrode connected with the pulse generation module, the electrode can release stimulation current to the skin of the human body, and at least the electrode is arranged on the base body. The drug delivery patch is arranged on the base body, and the drug delivery patch comprises a drug which can be absorbed through the skin. Wherein the base body is suitable for being attached to the neck skin of a human body, so that the electrodes and the administration application are in contact with the neck skin, and the electrical stimulation signals and the drug efficacy act on a target neck area through the neck skin. The neck vagus nerve stimulation device is compact in structure, portable, easy to use, low in cost and capable of enhancing the treatment effect.

The invention relates to a neck vagus nerve stimulation device and a preparation method thereof. The neck vagus nerve stimulation device comprises a base body, an electrical stimulation unit and a heating piece. The base body is suitable for being attached to the neck of a human body; the electrical stimulation unit comprises a pulse generation module and an electrode connected with the pulse generation module, and at least the electrode is arranged on the base body so as to make contact with the neck skin to output an electrical stimulation signal when the base body is attached to the neck of the human body; the heating piece is arranged on the base body and used for heating the electrodes and / or the neck skin. The neck vagus nerve stimulation device provided by the invention can actively control the temperature, improves the use experience, and assists in improving the electrical stimulation curative effect through the heat effect.

The ear vagus nerve stimulator provided by the embodiment of the present application realizes non-invasive ear vagus nerve stimulation through a modular circuit design, avoids the risks and trauma of traditional implantable surgery. The internal electrical isolation architecture and constant current output control ensure accurate and adjustable stimulation energy while providing high use safety, effectively preventing the risk of electric leakage or overload. The device has high integration and strong portability, and is matched with a magnetic electrode and an ergonomic ear hanging structure, so that the device is stable, comfortable and easy to operate, greatly improving the user compliance and daily use convenience. Finally, the present application successfully converts professional nerve regulation technology into a safe, reliable and self-operated household health management tool, providing an innovative and inclusive solution for the auxiliary treatment and daily health intervention of chronic nerve function disorders.

According to the vagus nerve stimulation equipment provided by the invention, stimulation devices with different functions or shapes can be replaced according to needs, so that the connecting main body can be repeatedly used, and the use cost of a user can be reduced. The vagus nerve stimulation device comprises: a connection body which extends in a curved manner and is used for being hung on the neck; and the at least one stimulation device is detachably connected to the connecting main body and is used for outputting stimulation current to act on the neck vagus nerve.

The invention discloses a flexible closed-loop self-powered vagus nerve stimulation system for treating drug-resistant epilepsy. The system comprises a spiral electrode, a flexible friction nanometer generator and a flexible controller. According to the implantable vagus nerve stimulation system, the flexible material and the self-powered technology are adopted, effective stimulation on the vagus nerve is achieved, the tissue compatibility of the implantable vagus nerve stimulation system is remarkably improved, and secondary injury to a patient caused by battery replacement in an operation is avoided.

A system for treating a subject including a signaling device, a controller, and a stimulator. The signaling device is in communication with the input of the controller and is configured to send a signal to the controller. The stimulator is in communication with the output of the controller and is configured to stimulate an auricular branch of a vagus nerve in an ear of a subject in response to the controller receiving the signal from the signaling device.

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

Systems for using vagus nerve stimulation to treat demyelination disorders and / or disorders of the blood brain barrier are described. The vagus nerve stimulation system described herein is configured to reduce or prevent demyelination and / or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

Methods of accelerating clot formation and increasing clot deposition in a hemophiliac subject. A vagal nerve stimulator (VNS) may be implanted in a hemophiliac subject. The hemophiliac subject may have developed antibodies to factor VIII and not been administered a clotting factor within the last 48 hours. The vagus nerve of the subject may be stimulated in a manner that increases platelet intracellular calcium and / or activates splenic acetylcholine-synthesizing T lymphocytes using the implanted VNS.

The taVNS system (100) comprises an electrode support (110) and upper and lower conchaecular electrodes (120, 130) attached to the electrode support (110), protruding from the electrode support (110) and configured to contact the skin of the upper and lower conchaecular ears of a human subject, respectively. An elastic headband (140) is attached to the electrode support (110) and is configured to apply pressure to the electrode support (110) so that, when attached to the head of a human subject, the upper and lower conchaecular electrodes (120, 130) are pressed against the skin of the upper and lower conchaecular ears of the human subject.

The invention relates to a vagus nerve stimulation device which comprises a shell, at least two electrodes, conductive assemblies and a control module, the at least two electrodes are rotatably arranged at one end of the shell, the control module is arranged in the shell, and each electrode is electrically connected with the control module through one conductive assembly so as to output stimulation current through the electrode. The conductive assembly is provided with a rotatable conductive movable part, and the electrode is in contact with the conductive movable part. According to the vagus nerve stimulation device provided by the invention, when the electrode is used for searching the vagus nerve on the human skin, the electrode can roll on the human skin, so that the friction force on the human skin can be reduced. And the conductive assembly is provided with the rotatable conductive movable part, so that the friction force between the electrode and the conductive movable part can be reduced, the electrode is enabled to rotate more easily when moving on the skin of the human body, the friction force between the electrode and the skin during use is further reduced, and the use comfort of the vagus nerve stimulation device is improved.

Methods for treating patients receiving a medication are disclosed. A patient is administered a medication with a propensity to cause inflammation or inflammation-related side effects, or actually experiences inflammation or inflammation-related side effects in response to receiving a medication. In response, vagus nerve stimulation is provided to the patient to relieve the inflammation or inflammation-related side-effect(s). The vagus nerve stimulation may be delivered by a transcutaneous system. Any of mechanical, optical, and / or electrical energy, pulses, power, etc. may be used to target the vagus nerve. Some examples deliver the stimulation to the auricular branch of the vagus nerve.

The invention relates to a neck vagus nerve stimulation device and a preparation method thereof. The neck vagus nerve stimulation device comprises a base body, an electrical stimulation generation module and a conductive adhesion part. The electrical stimulation generation module is used for generating an electrical stimulation signal; the conductive adhesion part is arranged on the base body and is electrically connected with the electrical stimulation generation module; the neck vagus nerve stimulation device is provided with a medicine which can be absorbed through the skin, and the conductive adhesion part can be adhered to the neck skin of a human body to serve as an electrode to output an electrical stimulation signal and enable the medicine to make contact with the neck skin, so that the electrical stimulation signal and the medicine efficacy act on a target neck area through the neck skin. The neck vagus nerve stimulation device provided by the invention is compact in structure, portable, easy to use and low in cost, has electrical stimulation and drug treatment functions, and can enhance the treatment effect.

1. Name of the product in this design: Vagotomy device main unit. 2. Purpose of this design: It is used in the treatment of vagus nerve stimulation in the concha, and can be used by hand or placed on a table to complete the treatment of symptoms related to vagus nerve stimulation in the concha. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.