Drug sustained-release alginic acid embolism microsphere and preparation method thereof

A technology of embolic microspheres and sodium alginate, which is applied in medical science, surgery, surgical adhesives, etc., can solve the problem of lack of release performance of drug-loaded alginate embolic microspheres, and achieve in situ controlled release, Increase the adsorption capacity and evenly distribute the effect

Inactive Publication Date: 2020-10-16
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, there is currently no one-step method for the preparation of alginate embolic microspheres with sustained release of drugs, and the research on the preparation of alginate microspheres by electrostatic spraying process, process amplification and release performance of drug-loaded alginate embolic microspheres, etc. lack of related research

Method used

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  • Drug sustained-release alginic acid embolism microsphere and preparation method thereof
  • Drug sustained-release alginic acid embolism microsphere and preparation method thereof
  • Drug sustained-release alginic acid embolism microsphere and preparation method thereof

Examples

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preparation example Construction

[0039] For the preparation of drug slow-release alginate embolism microspheres, the electrospray solution in step 1 is left to stand for 5-20 minutes, and the multi-nozzle electrostatic spray technology is used to spray it into the receiving solution through a multi-nozzle electrostatic spray device under a high-voltage electric field, and spray The receiving solution is stirred slowly during the process to obtain a mixed solution rich in alginic acid microspheres. The injection speed of the electrospray solution during the electrostatic spraying process is 0.1-20mL / hr; the nozzle model is 15G-30G, and the number of nozzles is 1-200; the voltage of the electrostatic spray is 3-30kV, and the distance between the nozzle and the liquid surface of the receiving solution The distance is 2-25cm. The key process parameters during single nozzle processing are that the nozzle of the spray device is provided with an annular coil located 2cm below the nozzle, and the annular coil is conn...

Embodiment 1

[0042] Example 1: Preparation of drug sustained-release calcium alginate microspheres by one-step multi-nozzle electrostatic spraying technology

[0043] This example only uses four-head electrostatic spray equipment to cite some examples, showing that drug sustained-release calcium alginate microspheres can be prepared by one-step multi-nozzle electrostatic spray technology.

[0044] The sodium alginate solution and the doxorubicin hydrochloride solution were stirred in the dark for 3 hours, and the concentration of sodium alginate in the obtained mixed solution was 2.5% (g / mL), and the concentration of doxorubicin hydrochloride was 2 mg / mL. Use the mixed solution as the electrospray solution, put it in such as figure 1 In the sampling device of the shown four-head electrostatic spray equipment, spray 0.4mol / L calcium chloride (CaCl 2 ) solution, and slowly stir the receiving solution. The calcium chloride receiving solution is placed 9cm directly below the nozzle and groun...

Embodiment 2

[0046] Example 2: Preparation of drug sustained-release barium alginate microspheres by one-step multi-nozzle electrostatic spraying technology

[0047] This example is only used as a partial example, showing that the loaded drugs can be different positively charged chemotherapeutic drugs, and the receiving solution can be different divalent or trivalent metal salt solutions.

[0048] Change the medicine in the electrospray solution in embodiment 1 into the irinotecan solution of 2mg / mL, and change the receiving solution into 0.4mol / L barium nitrate Ba(NO 3 ) 2 Solution, other of preparation method are identical with embodiment 1. Barium alginate microspheres loaded with irinotecan were prepared by a one-step multi-nozzle electrostatic spraying technique, and the morphology and size of the obtained microspheres were the same as the calcium alginate microspheres loaded with doxorubicin obtained in Example 1. It shows that the changes of chemotherapeutic drugs in the electrosp...

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Abstract

The invention discloses a drug sustained-release alginic acid embolism microsphere and a one-step electrostatic spraying preparation method thereof. Sodium alginate is compounded with a chemotherapeutic drug with positive charges, and the drug-loaded alginic acid embolic microsphere is prepared through a multi-nozzle one-step electrostatic spraying technology, so that combined treatment of embolism treatment and chemotherapy is realized. According to the multi-nozzle one-step electrostatic spraying preparation method provided by the invention, the drug sustained-release embolism microsphere can be prepared in one step, the prepared microsphere is uniform in particle size and controllable in size, the diameter is 100-1000 microns, and the microsphere has the potential of large-scale production. According to the alginic acid embolism microsphere provided by the invention, the drug loading capacity of common embolism microspheres is greatly improved, long-term slow release of chemotherapeutic drugs can be realized, nutrient source blood supply required by tumor growth can be blocked, the local drug concentration of a focus part can be improved, and meanwhile, the drug concentration inother organs is reduced, toxic and side effects are reduced, synergistic treatment of embolism treatment and chemotherapy is achieved, and the method has great development prospects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a drug slow-release alginate embolism microsphere and a one-step electrostatic spray preparation method thereof. Background technique [0002] According to the latest global cancer report released by the World Health Organization in 2018, the number of new liver cancer patients in China has exceeded 400,000 per year, accounting for more than half of the world's new patients, and the 5-year survival rate of liver cancer patients is less than 5%. It has become the cancer with the second highest mortality rate in Chinese men. The guidelines for the diagnosis and treatment of liver cancer in China, the United States and Japan all regard transcatheter arterial chemoembolization (TACE) as the recommended treatment for liver cancer. TACE can selectively deliver embolic agents and chemotherapeutic drugs to the target site, and at the same time cut off the blood supply of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/0015A61L24/08A61L2300/416A61L2300/602C08L5/04
Inventor 杨祥良杜青万江陵李娇娇刘宏
Owner HUAZHONG UNIV OF SCI & TECH
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