30 results about "Kidney arteries" patented technology

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and / or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

The invention discloses an arterial clamp pressure adjusting device for a renal ischemia reperfusion injury experiment, and relates to the technical field of renal ischemia reperfusion injury experiments. The two connecting blocks are fixed through the rivets; and the two first elastic strips are fixed to the two rivets correspondingly, and a connecting plate is fixed to the end of each first elastic strip. When the pressure between the two clamp bodies is proper, operation is not needed, and blood flow of the renal artery can be obstructed through the two first elastic strips; when the pressure between the two clamp bodies is small, the pressure between the two clamp bodies can be increased by utilizing the elastic force supplementing assembly through the buckling type quick connection between the convex block and the fixing block after the installation is completed; and when the pressure between the two clamping bodies is large, the base body and the adjusting assembly can be continuously installed, and the elastic force compensation assembly is matched to reduce the force, away from each other, between the two connecting plates, so that the force between the two clamping bodies is reduced.

The application relates to a radiofrequency ablation system and a radiofrequency ablation clamp for renal sympathetic denervation, which comprises an upper jaw and a lower jaw that can be opened and closed relative to each other, the upper jaw is provided with upper jaw radiofrequency electrodes, the lower jaw is provided with lower jaw radiofrequency electrodes, the lower jaw comprises a lower jaw main body in an arc structure with an axis extending along a left-right direction, a lower electrode seat made of insulating material corresponding to each lower jaw radiofrequency electrode is movably arranged on the lower jaw main body in a circumferential direction, each lower jaw radiofrequency electrode is fixed on the corresponding lower electrode seat, the upper jaw radiofrequency electrodes are at least three, each upper jaw radiofrequency electrode is arranged in a left-right direction at intervals, the lower jaw radiofrequency electrodes are at least three, each lower jaw radiofrequency electrode is arranged in a left-right direction at intervals, and the radiofrequency ablation clamp further comprises an electrode seat driving mechanism for driving the circumferential movement of the corresponding upper electrode seat and lower electrode seat. The purpose of the application is to provide a radiofrequency ablation system capable of retaining part of parasympathetic nerves and a radiofrequency ablation clamp used in the radiofrequency ablation system.

The present application discloses and claims a kidney phantom consisting of a silicone rubber model featuring the anatomical shape of a human kidney, the renal artery, the renal vein, and a total of 11 tumors and 2 cysts. Each tumor is represented by a solid mass, while cysts are empty three-dimensional shapes. In order to accommodate the needs of both novice and advanced surgeons, tumors were designed with increasing surgical difficulty. The kidney phantom disclosed in the present application can be combined with a commercially available ensemble of laparoscopic tools to provide localized and remote training to surgeons and medical staff practicing laparoscopic and robotic partial nephrectomy.

The utility model discloses a dynamic teaching aid for simulating urine and hematuria forming processes. The dynamic teaching aid comprises a teaching aid bracket, a renal artery model, a globular arteriole model, a glomerulus model, a globular arteriole model, a capillary network model, a renal vein model, a renal capsule model and a bladder model, the renal artery model, the renal vein model, the renal capsule model and the bladder model are sequentially arranged on the teaching aid support; the glomerulus model is mounted in the kidney capsule model; a kidney tubule model is arranged at the bottom of the kidney capsule model, the tail end of the kidney tubule model is communicated with the bladder model, and decoloration cotton is distributed in the kidney capsule model; the capillary network is wound on the renal tubule model of the renal capsule model; one end of the ball-entering arteriole model is communicated with the renal artery model, and the other end is communicated with the glomerular model; one end of the bulbous arteriole model is communicated with the glomerulus model, and the other end is communicated with the capillary network model; and the tail end of the capillary network model is communicated with the renal vein model. The teaching aid has the advantages of being simple in structure, convenient to operate and capable of improving teaching quality.

An endoprosthesis system including branch features and fenestration features for perfusion of branch vessels, such as the renal, superior mesenteric, and celiac arteries.

Methods and devices for supporting circulation. The methods may include positioning a blood pump in the arterial vasculature or the venous vasculature. The methods may include positioning a pump portion of the blood pump in a descending aorta, an inferior vena cava, a renal artery, and / or a renal vein. The methods include delivering a pump portion of a blood pump to a target location and rotating one or more impellers to move blood through the pump portion.

The invention relates to the technical field of medical instruments, and particularly discloses an ablation electrode which comprises a needle tube, an ablation mechanism and a driving mechanism, the ablation mechanism is connected to the far end of the needle tube and provided with a plurality of ablation ends capable of moving in the radial direction of the needle tube, electrode plates are arranged at the ablation ends, and the electrode plates are evenly distributed in the circumferential direction of the needle tube at intervals; the driving mechanism drives the ablation mechanism to be switched between an opening state and a closing state, and in the opening state, the electrode slices protrude outwards to form an annular ablation area. The electrode plates are annularly distributed after being expanded, the attaching distance between the electrode plates and the blood vessel wall can be flexibly adjusted according to the inner diameter of the renal artery, the problem that non-coplanar electrode plates cannot adapt to blood vessels with different tube diameters is solved, meanwhile, the annularly distributed electrode plates can form complete energy coverage on the same radial section, ablation gaps are avoided, and the ablation efficiency is improved. Therefore, the sympathetic nerve fiber is comprehensively blocked, and the long-term effectiveness of blood pressure control is improved.

The invention discloses a catheter system for ablation of a renal artery trunk and branches, which comprises a catheter and an external device for providing and recycling a refrigerant, and the catheter is detachably connected with the external device; the catheter comprises a functional section, a connecting pipe and a plug which are connected in sequence, and the plug is detachably connected with external equipment; the functional section comprises a first freezing unit and a second freezing unit which are coaxially arranged; and the first freezing unit and the second freezing unit are respectively communicated with external equipment. According to the catheter system, the structures of the first freezing unit and the second freezing unit are designed, and nerve fibers of a renal artery trunk and branches are thoroughly ablated through the two freezing units, so that radical treatment of hypertension is realized.

The invention discloses an implantable intelligent blood pressure adjusting method and system based on a micro-nano ultrasonic device, and relates to the technical field of biomedical engineering.The implantable intelligent blood pressure adjusting method comprises the steps that a lithium niobate piezoelectric micromechanical ultrasonic transducer implanted near the renal door and the renal artery is controlled, and ultrasonic beams with the set center frequency are emitted to the blood vessel wall; echo signals reflected by the front wall and the rear wall of the blood vessel are collected; performing time domain peak detection on the echo signals, calculating the transit time of ultrasonic waves in a blood vessel cavity, calculating the instantaneous diameter of the blood vessel by combining the sound velocity, generating a real-time blood pressure value based on inversion of a blood vessel wall elastic mechanical model, and generating a blood pressure state judgment result; transmitting set intensity focused ultrasound to act on renal door sensory nerves according to a judgment result, and activating sensory pathways to release calcitonin gene-related peptides to induce vascular smooth muscle relaxation so as to reduce blood pressure. The lead-free single crystal lithium niobate piezoelectric micromechanical ultrasonic transducer is introduced, so that the biocompatibility and safety of the implanted device are greatly improved.

The application provides a real-time feedback imaging system for assisting percutaneous renal denervation, comprising a catheter assembly, a controller connected with the catheter assembly and an imaging element connected with the controller; wherein the catheter assembly is used for ablating an ablation site in a patient's body and collecting information about the ablation site; the controller is used for determining the catheter position, the ablated site and the ablation times of the site according to the real-time acquired fluoroscopy image of the catheter moving in the renal artery, and determining the ablation effect according to the information about the ablation site; the application has the beneficial effect that based on the image processing system and the sensing system, the application can real-time feedback the progress of RDN on the imaging element, including the catheter position, the ablated site, the ablation times of the site and the ablation effect, etc., which provides convenience for the operation of the operator, thereby improving the safety and effectiveness of RDN.

The invention discloses a renal artery balloon catheter device for local cold perfusion, and relates to the field of renal artery balloon catheters, the renal artery balloon catheter device comprises a catheter main body, and the outer surface of the catheter main body is fixedly connected with a mounting ring tube. The renal artery balloon catheter device for local cold perfusion is provided with the two fixing liquid bags, the catheter body can be stably fixed to the inner wall of the artery, the catheter is effectively prevented from sliding and shifting in the flushing process, and it is ensured that the cold perfusion position is accurate. Meanwhile, the sealing liquid bag is tightly attached to the inner wall of the artery after being swelled, reliable sealing is formed, and backflow of low-temperature liquid is prevented. The through holes in the mounting ring pipe are annularly and uniformly distributed, so that the cold liquid uniformly enters the liquid bag, the expansion uniformity is ensured, and the fixing and sealing effects are further improved. In the flushing process, the valve reducing mechanism enables the fixed liquid bag and the sealed liquid bag to be always kept plump, low-temperature liquid evenly flows out through the liquid outlet holes, pressure is reduced, the artery wall is prevented from being damaged, and stable and efficient cold perfusion on the kidney is achieved.

The invention provides a renal artery stenosis ultrasonic diagnosis report automatic generation method, and relates to the technical field of image data processing, and the method comprises the steps: inputting a plurality of renal artery ultrasonic images, carrying out the redundancy processing, calculating the semantic correlation between each image and a diagnosis text, and screening out a key image; performing feature extraction and enhancement on the screened key images, constructing a static medical knowledge memory matrix, and aligning enhanced visual features with the static medical knowledge memory matrix to generate knowledge alignment vectors; maintaining a dynamic memory network, and injecting the knowledge alignment vector into the dynamic memory network; and fusing the external knowledge token into a code, and finally outputting a structured renal artery ultrasonic diagnosis report based on the enhanced visual features, the external knowledge token and the dynamic memory network state. According to the method, redundant information processing and fine-grained feature extraction of the renal artery ultrasonic image are realized, and external medical knowledge is guided to generate a long ultrasonic diagnosis report which is consistent in logic and has clinical interpretability.

1. Name of the product in this design: Renal Artery Ultrasonic Ablation Device. 2. Application of this design: It is suitable for the main equipment in a clinical renal artery ultrasound ablation system, used to provide ultrasound energy drive, monitoring and control support during transcatheter renal artery ablation. This device does not come into direct contact with the patient or the medium and can be used in medical scenarios such as interventional catheter surgery. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design points: Component 1 3D view 1. 5. Other situations requiring explanation: Component 1 is the host, and component 2 is the controller.

This application discloses a method, system, electronic device, and storage medium for generating renal artery ultrasound reports. The method includes: keyword matching of the clinical examination text of the ultrasound case to obtain renal artery diagnostic indicators; generating search prompts based on the renal artery diagnostic indicators; acquiring general medical knowledge and clinical expert specialty knowledge from a large model and obtaining global dual-source knowledge embedding; encoding the clinical examination text of the ultrasound case to generate basic embedding; obtaining knowledge fusion residual features based on the basic embedding and global dual-source knowledge embedding; extracting features from multiple frames of ultrasound images of the renal artery to be examined to obtain visual global features; performing element-wise additive fusion of the visual global features, global dual-source knowledge embedding, and knowledge fusion residual features to obtain global unified features; and generating a renal artery ultrasound diagnostic report based on the global unified features. Through the above settings, the diagnostic accuracy and terminology standardization of the report can be improved.

The present invention relates to a method of delivering a viral vector to a subject's kidney, the method comprising: (a) inserting a catheter into the renal artery; (b) optionally inflating a balloon to occlude the renal artery; and (c) injecting or infusing the viral vector into the renal artery via the catheter. The present invention also relates to a viral vector for use in therapy, wherein the viral vector is delivered by said method.

A method for the treatment of a patient for the purpose of lowering blood pressure and / or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

The present application relates to a kind of navigation system for renal artery denervation, navigation method, computer equipment, belong to surgical navigation technical field, solve the problem of insufficient two-dimensional perspective information in prior art, contrast propagation depends on experience.System includes three-dimensional blood vessel modeling module, for the three-dimensional reconstruction of the acquired CBCT projection sequence, obtain reconstruction body data, then gradually carry out three-dimensional blood vessel modeling, center line extraction, obtain the vascular topology skeleton, including blood vessel center line and multiple blood vessel nodes;Contrast propagation prediction module is used to obtain contrast agent injection point information, combined with vascular topology skeleton, carries out contrast agent propagation path prediction, generates corresponding contrast reachable area;Image mapping fusion module is used to fuse three-dimensional blood vessel surface model, contrast reachable area and the real-time perspective image obtained, generate fusion image.The present application realizes contrast propagation prediction, three-dimensional contrast path superposition, improves navigation accuracy, reduces contrast agent use.

The invention provides a medical guide wire and a medical system. The medical guide wire comprises a guide wire core and an ultrasonic transducer module, the guide wire core comprises a main body section; and the ultrasonic transducer module is arranged on the far-end side wall of the main body section and is at least partially exposed. The outer diameter of the medical guide wire can be smaller than 2 mm, and the medical guide wire can enter small blood vessels, so that the medical guide wire can be used for ablation of sympathetic nerves near second-level branches and secondary renal arteries of the renal artery, and the effect of lowering blood pressure is achieved.

The application discloses a kind of multimodal image automatic registration methods for renal artery denervation operation navigation, comprising the following steps: collecting preoperative CTA image and intraoperative respiratory gating CBCT image of patient, and uniform image format;Extract the kidney and blood vessel area in the CTA image and CBCT image, and the kidney and blood vessel area image extracted are preprocessed;Adopt conditional generative adversarial network to generate sCT image, realize the bridging of CBCT to CT mode;With the registration of sCT and CTA image by deep learning non-rigid registration network, the registered image is used for intraoperative 3D navigation.The method provides renal artery opening positioning reference and catheter position assistance for the operator, effectively replaces manual adjustment, significantly improves the efficiency and safety of operation, and provides a new intelligent navigation tool for the interventional treatment of hypertension.

A cryo-ablation system treats conditions associated with sympathetic nervous system hyperactivity using a catheter with a configurable heat transfer element that transitions from a flat delivery profile to deployed configurations including helical shapes. The system includes deployable temperature probes that directly measure tissue temperature at target locations inside or outside blood vessels. A computational control system processes temperature data from multiple sensors and deployable probes to calculate real-time lethal isotherm progression using heat transfer modeling algorithms. The system provides vessel occlusion during treatment and real-time feedback for treatment optimization. Methods include introducing the catheter into a renal artery, deploying the heat transfer element, occluding the vessel, deploying temperature probes to target locations within or outside the vessel, delivering cryogenic temperatures while monitoring probe temperatures, and terminating treatment based on computational analysis of temperature data to achieve target ablation depths.

The utility model provides a surgical instrument for removing renal artery sympathetic nerves, and relates to the technical field of medical instruments. According to the surgical instrument for removing renal artery sympathetic nerves, the surgical instrument can be well attached to blood vessels, the risk that the blood vessels are excessively pressed by the surgical instrument can be reduced, and therefore the surgical efficiency and safety can be improved. The surgical instrument for removing renal artery sympathetic nerves comprises an operating assembly, a connecting assembly and a clamping assembly. Wherein the operating assembly is connected with one end of the connecting assembly; the two clamping assemblies are movably connected to the end, away from the operation assembly, of the connecting assembly, the clamping face of each clamping assembly is matched with the shape of an operation object, and after the operation assembly drives the connecting assembly to move so that the connecting assembly can drive the two clamping assemblies to get close to each other, the clamping faces of the two clamping assemblies define a clamping space.

Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys. A closed circuit may be formed with a perfusion catheter positioned in the renal artery of the kidney, a recovery catheter positioned in the renal vein of the kidney, and an external membrane oxygenator disposed therebetween. A perfusate containing, for example, a drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.

The invention discloses an ultrasonic ablation balloon catheter and ultrasonic ablation equipment, and relates to the technical field of ultrasonic ablation, and the ultrasonic ablation balloon catheter comprises a semi-compliance balloon which is of a hollow closed structure; the multi-cavity tube is connected to the near end of the semi-compliant balloon, a filling cavity channel and a guide wire cavity channel which do not communicate with each other and extend in the axis direction of a tube body of the multi-cavity tube are formed in the multi-cavity tube, and the far end of the filling cavity channel and the far end of the guide wire cavity channel communicate with the near end of the semi-compliant balloon; the far end of the inner tube sequentially penetrates through the guide wire cavity and an inner cavity of the semi-compliant balloon and extends out of the far end position of the semi-compliant balloon, and the inner tube is in sealing fit with the guide wire cavity and the far end position of the semi-compliant balloon; the ultrasonic transducer is located in the semi-compliant balloon and fixed to the inner tube, the requirement for different blood vessel diameters of a renal artery trunk and branches can be met, the time for repeatedly replacing an ultrasonic ablation balloon catheter in an operation can be shortened, and the risk of vascular complications is reduced.

The invention discloses a method for constructing a renal ischemia reperfusion mouse model, and relates to the technical field of animal model construction, and the method is characterized by comprising the following steps: S1, anesthetizing a mouse; s2, fixing and disinfecting the mouse; s3, cutting the skin, separating layer by layer, and exposing kidney tissues and blood vessels; the kidney is rotated by 360 degrees with the renal artery as the axis, the rotation state is maintained for 30 minutes, and then the kidney is reset to open renal blood flow; and S5, suturing the surgical incision. According to the constructed mouse model, on the basis of effectively blocking artery blood flow, the complexity of surgical operation is reduced, the total renal artery is protected to the maximum extent, renal blood flow supply after recanalization is guaranteed, and the renal artery blood flow is blocked within a certain time without damaging blood vessels. And a good and stable animal model is provided for better researching the mechanism of acute kidney injury and innovative treatment schemes in the future.

The application discloses a renal artery balloon catheter device for local cold perfusion, and relates to the field of renal artery balloon catheter devices, which comprises a catheter main body, and an installation ring pipe is fixedly connected to the outer surface of the catheter main body. The renal artery balloon catheter device for local cold perfusion has two fixed liquid sacs, can stably fix the catheter main body to the inner wall of an artery, effectively prevents the catheter from sliding and deviating during the flushing process, and ensures the accuracy of the cold perfusion position. Meanwhile, the sealed liquid sac is tightly combined with the inner wall of the artery after being inflated, forms reliable sealing, and prevents the backflow of low-temperature liquid. The internal through holes of the installation ring pipe are annularly and uniformly distributed, cold liquid is uniformly introduced into the liquid sac, the uniformity of expansion is ensured, and the fixing and sealing effects are further improved. During the flushing, the pressure reducing valve mechanism keeps the fixed liquid sac and the sealed liquid sac inflated at all times, the low-temperature liquid is uniformly discharged through multiple liquid outlet holes, the pressure is reduced, the arterial wall is prevented from being damaged, and stable and efficient cold perfusion of the kidney is realized.

The invention discloses an implantable hypertension self-adaptive closed-loop treatment system and method based on multi-sensor fusion, and relates to the crossing field of medical instruments and biomedical engineering.The system comprises a distributed blood pressure sensing array, an implantable main processing unit, a multi-target execution unit and an external programmer. The sensing array is attached to the outer wall of the ascending aorta in a surrounding mode to collect multi-point pressure signals. The main processing unit executes a blood pressure reconstruction and control decision algorithm and drives the execution unit; the execution unit comprises a carotid sinus and renal artery area double-nerve stimulation electrode and a renal artery local trace drug delivery device; the programmer is used for target setting and calibration. The method comprises the steps of collecting multi-channel signals, performing time-dependent alignment, performing weighted fusion and performing inverse compensation on a blood vessel wall transfer function to reconstruct blood pressure, sequentially activating stimulation or dosing according to a grading strategy, periodically calibrating and updating a model, additionally having a preventive self-maintenance function, infusing anti-fibrosis drugs to prevent wrapping, monitoring electric quantity, impedance and other abnormalities, and performing degraded operation.