72 results about "Kidney arteries" patented technology

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and / or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

The invention discloses an arterial clamp pressure adjusting device for a renal ischemia reperfusion injury experiment, and relates to the technical field of renal ischemia reperfusion injury experiments. The two connecting blocks are fixed through the rivets; and the two first elastic strips are fixed to the two rivets correspondingly, and a connecting plate is fixed to the end of each first elastic strip. When the pressure between the two clamp bodies is proper, operation is not needed, and blood flow of the renal artery can be obstructed through the two first elastic strips; when the pressure between the two clamp bodies is small, the pressure between the two clamp bodies can be increased by utilizing the elastic force supplementing assembly through the buckling type quick connection between the convex block and the fixing block after the installation is completed; and when the pressure between the two clamping bodies is large, the base body and the adjusting assembly can be continuously installed, and the elastic force compensation assembly is matched to reduce the force, away from each other, between the two connecting plates, so that the force between the two clamping bodies is reduced.

The invention relates to the field of intelligent medical treatment, in particular to a data processing method and device for renal artery FFR evaluation and a program product. Comprising the following steps: acquiring continuous time sequence frame data of renal arteriography; frame selection is carried out on the time sequence frame data of the renal arteriography to obtain a multi-time sequence, the multi-time sequence comprises a key frame and N effective frames, and N is a natural number larger than 1; the multiple time sequences are output to a segmentation model for renal artery blood vessel segmentation, and renal artery blood vessel masks of key frames and effective frames are obtained; the key frame and the mask of the key frame are sequentially registered with N effective frames and masks of the effective frames based on L scales to obtain L * N registered effective frame data; and performing 2.5 D data construction based on the registered effective frame data and key frame data to obtain 2.5 D data for FFR evaluation of the renal artery. The application has good clinical value.

The invention provides a renal artery ultrasonic ablation catheter and a renal artery ultrasonic ablation device, and relates to the technical field of renal artery ablation equipment.The renal artery ultrasonic ablation catheter comprises a far-end tube and a near-end tube, the far-end tube is communicated with the near end of a balloon, a far-end filling cavity and a guide wire exchange cavity are formed in the far-end tube, and the far end of the far-end filling cavity is communicated with the balloon; the guide wire exchange cavity is used for penetrating through an inner tube; the near-end tube is connected with the near end of the far-end tube, a near-end filling cavity is formed in the near-end tube, the far end of the near-end filling cavity is communicated with the near end of the far-end filling cavity, the near end of the near-end filling cavity is used for being connected with filling equipment, and a gap allowing a guide wire to penetrate in or out of a near-end port of the guide wire exchange cavity is formed between the far end of the near-end tube and the guide wire exchange cavity; the balloon can be taken out under the condition that the position of the guide wire in the blood vessel is not changed, the time for replacing the balloon can be obviously shortened, and therefore the operation time is shortened, and the occurrence of vascular complications is reduced.

The application relates to a radiofrequency ablation system and a radiofrequency ablation clamp for renal sympathetic denervation, which comprises an upper jaw and a lower jaw that can be opened and closed relative to each other, the upper jaw is provided with upper jaw radiofrequency electrodes, the lower jaw is provided with lower jaw radiofrequency electrodes, the lower jaw comprises a lower jaw main body in an arc structure with an axis extending along a left-right direction, a lower electrode seat made of insulating material corresponding to each lower jaw radiofrequency electrode is movably arranged on the lower jaw main body in a circumferential direction, each lower jaw radiofrequency electrode is fixed on the corresponding lower electrode seat, the upper jaw radiofrequency electrodes are at least three, each upper jaw radiofrequency electrode is arranged in a left-right direction at intervals, the lower jaw radiofrequency electrodes are at least three, each lower jaw radiofrequency electrode is arranged in a left-right direction at intervals, and the radiofrequency ablation clamp further comprises an electrode seat driving mechanism for driving the circumferential movement of the corresponding upper electrode seat and lower electrode seat. The purpose of the application is to provide a radiofrequency ablation system capable of retaining part of parasympathetic nerves and a radiofrequency ablation clamp used in the radiofrequency ablation system.

To provide a peri-vascular tissue ablation catheter capable of delivering an ablation liquid for circumferentially damaging tissue in or near an outer layer of a vessel of a human body.SOLUTION: Provided is an intravascular catheter for peri-vascular and / or periurethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and / or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.SELECTED DRAWING: Figure 1

The present application discloses and claims a kidney phantom consisting of a silicone rubber model featuring the anatomical shape of a human kidney, the renal artery, the renal vein, and a total of 11 tumors and 2 cysts. Each tumor is represented by a solid mass, while cysts are empty three-dimensional shapes. In order to accommodate the needs of both novice and advanced surgeons, tumors were designed with increasing surgical difficulty. The kidney phantom disclosed in the present application can be combined with a commercially available ensemble of laparoscopic tools to provide localized and remote training to surgeons and medical staff practicing laparoscopic and robotic partial nephrectomy.

A method of treating a renal condition by topical region perfusion of one or both kidneys of a patient is disclosed. A closed circuit is formed with a perfusion catheter positioned in the renal artery of the kidney, a recovery catheter positioned in the renal vein of the kidney, and an extracorporeal membrane oxygenator disposed therebetween. Perfusate containing, for example, a gene therapy drug may circulate through the closed circuit while isolating the closed circuit from the systemic circulation of the patient.

The utility model discloses a dynamic teaching aid for simulating urine and hematuria forming processes. The dynamic teaching aid comprises a teaching aid bracket, a renal artery model, a globular arteriole model, a glomerulus model, a globular arteriole model, a capillary network model, a renal vein model, a renal capsule model and a bladder model, the renal artery model, the renal vein model, the renal capsule model and the bladder model are sequentially arranged on the teaching aid support; the glomerulus model is mounted in the kidney capsule model; a kidney tubule model is arranged at the bottom of the kidney capsule model, the tail end of the kidney tubule model is communicated with the bladder model, and decoloration cotton is distributed in the kidney capsule model; the capillary network is wound on the renal tubule model of the renal capsule model; one end of the ball-entering arteriole model is communicated with the renal artery model, and the other end is communicated with the glomerular model; one end of the bulbous arteriole model is communicated with the glomerulus model, and the other end is communicated with the capillary network model; and the tail end of the capillary network model is communicated with the renal vein model. The teaching aid has the advantages of being simple in structure, convenient to operate and capable of improving teaching quality.

To provide agents for labeling and locating renal nerve.SOLUTION: A provided agent comprises human neuron or nerve-targeting molecule to be used by a method comprising: (a) contacting the renal nerve in the renal arterial wall with an agent, thereby labeling the renal nerve in the renal artery wall; and (b) illuminating the cargo through the renal artery wall in the kidney; receiving fluorescent light from the cargo; and using the received fluorescent light to determine the position of renal nerve in the renal artery wall during operation of a subject; and (c) using the position of the renal nerve in the renal artery wall for irradiating or guiding ablation of the renal nerve in the renal artery wall.SELECTED DRAWING: Figure 1

An endoprosthesis system including branch features and fenestration features for perfusion of branch vessels, such as the renal, superior mesenteric, and celiac arteries.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.

Blood flow to the kidney primarily comes from the renal arteries which are controlled by the renal plexus. This plexus is innervated by the sympathetic chain and dorsal root ganglion upstream. In this embodiment neuromodulation of dorsal root ganglion between T8 and L3 can be used to alter renal blood flow and, thus, blood pressure. The neuromodulation at at frequencies between 0.01 Hz and 19.99 Hz at these DRG levels can be used to increase blood flow to the kidneys and to treat hypertension.

Methods and devices for supporting circulation. The methods may include positioning a blood pump in the arterial vasculature or the venous vasculature. The methods may include positioning a pump portion of the blood pump in a descending aorta, an inferior vena cava, a renal artery, and / or a renal vein. The methods include delivering a pump portion of a blood pump to a target location and rotating one or more impellers to move blood through the pump portion.

The invention relates to the technical field of medical instruments, and particularly discloses an ablation electrode which comprises a needle tube, an ablation mechanism and a driving mechanism, the ablation mechanism is connected to the far end of the needle tube and provided with a plurality of ablation ends capable of moving in the radial direction of the needle tube, electrode plates are arranged at the ablation ends, and the electrode plates are evenly distributed in the circumferential direction of the needle tube at intervals; the driving mechanism drives the ablation mechanism to be switched between an opening state and a closing state, and in the opening state, the electrode slices protrude outwards to form an annular ablation area. The electrode plates are annularly distributed after being expanded, the attaching distance between the electrode plates and the blood vessel wall can be flexibly adjusted according to the inner diameter of the renal artery, the problem that non-coplanar electrode plates cannot adapt to blood vessels with different tube diameters is solved, meanwhile, the annularly distributed electrode plates can form complete energy coverage on the same radial section, ablation gaps are avoided, and the ablation efficiency is improved. Therefore, the sympathetic nerve fiber is comprehensively blocked, and the long-term effectiveness of blood pressure control is improved.

Systems having energy delivering thermocouple assemblies for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral / helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).

The invention discloses an improved multi-electrode renal nerve ablation catheter and a using method thereof. The improved multi-electrode renal nerve ablation catheter comprises a catheter body, a control line and an umbrella-shaped structure. A hollow channel is formed in the catheter body, the control line is arranged in the hollow channel, the tail end of the control line extends out of the tail end of the catheter body, and the umbrella-shaped structure is located at the tail end of the control line. The umbrella-shaped structure comprises a plurality of elastic petals, the elastic petals are arranged in a surrounding mode, the tail ends of the elastic petals are connected with the control line, the gathering degree of the elastic petals is adjusted by adjusting the tightness of the control line, and then the front end of the catheter body is adjusted to be bent to the needed angle and position. By means of the innovative catheter design and operation method, the flexibility of the catheter when the catheter enters a branch blood vessel and the good attachment of the catheter in the renal artery are achieved, and therefore the accuracy of an operation and the treatment effect of a patient are improved.

This invention relates to a device for mapping and ablating the renal nerves distributed on the renal artery, said device comprising a guide catheter, a mapping-ablation catheter, a handle and a connector. The guide catheter has at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter is housed in one of the lumens of the guide catheter and its distal end has one or more electrodes and one or more detecting devices. The distal end of the mapping-ablation catheter is curved, rotatable, and can be extended out of or retracted into the guide catheter. The handle connects the guide catheter and mapping-ablation catheter, and comprises one or more controlling components for controlling the movement of the guide catheter and mapping-ablation catheter. The connector is designed to supply energy to the electrodes.

The invention discloses a catheter system for ablation of a renal artery trunk and branches, which comprises a catheter and an external device for providing and recycling a refrigerant, and the catheter is detachably connected with the external device; the catheter comprises a functional section, a connecting pipe and a plug which are connected in sequence, and the plug is detachably connected with external equipment; the functional section comprises a first freezing unit and a second freezing unit which are coaxially arranged; and the first freezing unit and the second freezing unit are respectively communicated with external equipment. According to the catheter system, the structures of the first freezing unit and the second freezing unit are designed, and nerve fibers of a renal artery trunk and branches are thoroughly ablated through the two freezing units, so that radical treatment of hypertension is realized.

Microwave catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a microwave transmission element to a renal artery via an intravascular path. Renal neuromodulation may be achieved via dielectric heating in the presence of microwave irradiation that modulates neural fibers that contribute to renal function or alters vascular structures that feed or perfuse the neural fibers.

The invention discloses an implantable intelligent blood pressure adjusting method and system based on a micro-nano ultrasonic device, and relates to the technical field of biomedical engineering.The implantable intelligent blood pressure adjusting method comprises the steps that a lithium niobate piezoelectric micromechanical ultrasonic transducer implanted near the renal door and the renal artery is controlled, and ultrasonic beams with the set center frequency are emitted to the blood vessel wall; echo signals reflected by the front wall and the rear wall of the blood vessel are collected; performing time domain peak detection on the echo signals, calculating the transit time of ultrasonic waves in a blood vessel cavity, calculating the instantaneous diameter of the blood vessel by combining the sound velocity, generating a real-time blood pressure value based on inversion of a blood vessel wall elastic mechanical model, and generating a blood pressure state judgment result; transmitting set intensity focused ultrasound to act on renal door sensory nerves according to a judgment result, and activating sensory pathways to release calcitonin gene-related peptides to induce vascular smooth muscle relaxation so as to reduce blood pressure. The lead-free single crystal lithium niobate piezoelectric micromechanical ultrasonic transducer is introduced, so that the biocompatibility and safety of the implanted device are greatly improved.

The application provides a real-time feedback imaging system for assisting percutaneous renal denervation, comprising a catheter assembly, a controller connected with the catheter assembly and an imaging element connected with the controller; wherein the catheter assembly is used for ablating an ablation site in a patient's body and collecting information about the ablation site; the controller is used for determining the catheter position, the ablated site and the ablation times of the site according to the real-time acquired fluoroscopy image of the catheter moving in the renal artery, and determining the ablation effect according to the information about the ablation site; the application has the beneficial effect that based on the image processing system and the sensing system, the application can real-time feedback the progress of RDN on the imaging element, including the catheter position, the ablated site, the ablation times of the site and the ablation effect, etc., which provides convenience for the operation of the operator, thereby improving the safety and effectiveness of RDN.

The invention discloses a renal artery balloon catheter device for local cold perfusion, and relates to the field of renal artery balloon catheters, the renal artery balloon catheter device comprises a catheter main body, and the outer surface of the catheter main body is fixedly connected with a mounting ring tube. The renal artery balloon catheter device for local cold perfusion is provided with the two fixing liquid bags, the catheter body can be stably fixed to the inner wall of the artery, the catheter is effectively prevented from sliding and shifting in the flushing process, and it is ensured that the cold perfusion position is accurate. Meanwhile, the sealing liquid bag is tightly attached to the inner wall of the artery after being swelled, reliable sealing is formed, and backflow of low-temperature liquid is prevented. The through holes in the mounting ring pipe are annularly and uniformly distributed, so that the cold liquid uniformly enters the liquid bag, the expansion uniformity is ensured, and the fixing and sealing effects are further improved. In the flushing process, the valve reducing mechanism enables the fixed liquid bag and the sealed liquid bag to be always kept plump, low-temperature liquid evenly flows out through the liquid outlet holes, pressure is reduced, the artery wall is prevented from being damaged, and stable and efficient cold perfusion on the kidney is achieved.

The utility model provides a medical guide wire and a medical system. The medical guide wire comprises a guide wire core and an ultrasonic transducer module, the guide wire core comprises a main body section; and the ultrasonic transducer module is arranged on the far-end side wall of the main body section and is at least partially exposed. The outer diameter of the medical guide wire can be smaller than 2 mm, and the medical guide wire can enter small blood vessels, so that the medical guide wire can be used for ablation of sympathetic nerves near second-level branches and secondary renal arteries of the renal artery, and the effect of lowering blood pressure is achieved.

The invention provides a renal artery stenosis ultrasonic diagnosis report automatic generation method, and relates to the technical field of image data processing, and the method comprises the steps: inputting a plurality of renal artery ultrasonic images, carrying out the redundancy processing, calculating the semantic correlation between each image and a diagnosis text, and screening out a key image; performing feature extraction and enhancement on the screened key images, constructing a static medical knowledge memory matrix, and aligning enhanced visual features with the static medical knowledge memory matrix to generate knowledge alignment vectors; maintaining a dynamic memory network, and injecting the knowledge alignment vector into the dynamic memory network; and fusing the external knowledge token into a code, and finally outputting a structured renal artery ultrasonic diagnosis report based on the enhanced visual features, the external knowledge token and the dynamic memory network state. According to the method, redundant information processing and fine-grained feature extraction of the renal artery ultrasonic image are realized, and external medical knowledge is guided to generate a long ultrasonic diagnosis report which is consistent in logic and has clinical interpretability.

The invention provides a method for grading and prognosis prediction of an old patient with renal artery stenosis. The method comprises the following steps: (1) acquiring RAS multi-modal multi-time-point ultrasonic image data of the old; (2) extracting a region of interest of the RAS ultrasonic image; (3) enhancing the image of the region of interest of the RAS ultrasonic image; and (4) grading the RAS by using the trained multi-modal US image fusion network model, and performing prognosis prediction on renal function deterioration by using the trained multi-time-point US fusion analysis network model. The deep learning grading diagnosis and prognosis prediction model of the multi-mode ultrasonic image is used for carrying out feature extraction on the multi-mode multi-time-point ultrasonic image, rapid and noninvasive accurate grading is carried out on RAS, and the prognosis risk of renal function deterioration of different treatment schemes is accurately predicted; therefore, clinical doctors are assisted in formulating accurate and individualized treatment schemes for the old RAS diseases, and the hygienic economic cost of families of patients is reduced.

1. Name of the product in this design: Renal Artery Ultrasonic Ablation Device. 2. Application of this design: It is suitable for the main equipment in a clinical renal artery ultrasound ablation system, used to provide ultrasound energy drive, monitoring and control support during transcatheter renal artery ablation. This device does not come into direct contact with the patient or the medium and can be used in medical scenarios such as interventional catheter surgery. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design points: Component 1 3D view 1. 5. Other situations requiring explanation: Component 1 is the host, and component 2 is the controller.