75 results about "Kidney arteries" patented technology

An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

A system and method is provided that is adapted to allow for rapid cannulation of a guidewire into a branch lumen extending from a main lumen in a body of a patient, and in particular into two renal arteries extending from an abdominal aorta wall. A dual lumen catheter shaft delivers first and second pre-shaped guidewires to the location of the renal arteries in the aorta, such that the first and second pre-shaped guidewires self-cannulate within the renal arteries. Additional guidewires and / or interventional devices may be incorporated into the system and method for use with the catheter shaft, or over the two pre-shaped guidewires, to meet a particular need for a particular patient or intended procedure.

Systems, devices, and methods for delivering treatment to the renal arteries are provided. Exemplary systems include a delivery catheter having a distal bifurcation, an introducer assembly comprising an introducer sheath in operative association with a Y-hub, wherein Y-hub includes a first port for receiving the delivery catheter and a second port for receiving a second catheter, and a constraint assembly for holding the distal bifurcation of the delivery catheter in a low-profile configuration when it is advanced distally beyond the introducer sheath.

Various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue.

A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.

A stent graft extends in a flow lumen to span a defective portion of the flow lumen and seal the defective portion from further blood contact. The stent graft includes a pair of apertures, from which extensions project into the renal arteries to seal the passage of blood into the renal arteries from the abnormality. The apertures are larger than the opening of the renal arteries, such that the apertures need not be centered with the renal arteries to enable placement of the extensions. The aperture opening and side branch extensions contain hook and loop structures to provide a variably positionable seal of the aperture opening.

A radiosurgical method for treating cardiorenal disease of a patient, the method including directing radiosurgery radiation from outside the patient towards one or more target treatment regions encompassing sympathetic ganglia of the patient so as to inhibit the cardiorenal disease. In an exemplary embodiment, the method further includes acquiring three dimensional planning image data encompassing the first and second renal arteries, planning an ionizing radiation treatment of first and second target regions using the three dimensional planning image data so as to mitigate the hypertension, the first and second target regions encompassing neural tissue of or proximate to the first and second renal arteries, respectively, and remodeling the target regions by directing the planned radiation from outside the body toward the target regions.

Techniques for assessing a physiological profile of a patient include advancing a catheter shaft of a bifurcated renal catheter system into an aorta of the patient, deploying branches of the bifurcated renal catheter system into the renal arteries of the patient, detecting a renal arterial physiological parameter with a sensing mechanism, and assessing the physiological profile of the patient based on the physiological parameter. Related techniques include modifying or initiating pharmacological or surgical treatments for the patient based on the assessment.

The invention discloses a radio frequency cable controlled ablation catheter system for removing a sympathetic nerve from a renal artery. The system comprises an ablation catheter, a control handle and an ablation generation device, wherein a guiding catheter can be arranged or is not arranged. The ablation catheter sequentially consists of a catheter body section and an ablation section from a near end to a far end, and is characterized in that the front end of the catheter body section also comprises a controllable bending section; the controllable bending section is connected with the control handle through the catheter body section; and the ablation section is provided with at least two independent structures, and an ablation head is arranged on at least one independent structure. The system can simultaneously perform multi-point ablation, monitors an ablation effect in real time during operation, and has relatively high mechanical stability.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

The present invention includes a method and apparatus to perform rapid multi-slice MR imaging without ECG gating or requiring breath-holding that is capable of renal profusion analysis and angiographic screening. An ungated interleaved pulse sequence is applied in rapid succession, followed by a delay interval. The ungated interleaved pulse sequence is repeatedly played out with the predefined delay interval between each application of the pulse sequence. The resulting images provide not only a series of temporal phases of contrast-enhanced blood uptake for renal profusion analysis, but also provide enough dynamic range to include angiographic screening of the renal arteries.

Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Systems and methods are provided for locally delivering specific prophylactic, regenerative, or therapeutic agents within the body of a patient. Systems and methods can involve direct delivery of prophylactic, regenerative, or therapeutic agents into branch blood vessels or body lumens from a main vessel or lumen, respectively, and in particular into renal arteries extending from an aorta in a patient. Drug infusion techniques encompass specific treatment and prevention regimes for renal diseases including, but not limited to, Acute Kidney Injury, Renal Cell Carcinoma, Polycystic Kidney Disease, and Chronic Kidney Disease.

The present invention relates to an apparatus for mapping and ablating renal nerves distributed on renal arteries. The apparatus comprises a guiding catheter, a mapping and ablating catheter, a handle and a joint, wherein the guiding catheter has a front end which can control a degree of curvature of the catheter and is internally provided with at least one chamber; the mapping and ablating catheter is arranged in one chamber of the guiding catheter and is provided with one or more electrodes and one or more detection devices at the head end; the mapping and ablating catheter has a front end which has a degree of curvature, can stretch out of or retract back in the guiding catheter and is rotatable; the handle connects the guiding catheter and the mapping ablation catheter and comprises one or more control elements which are used for move the guiding catheter and the mapping ablating catheter; and the joint is used for providing energies for the electrodes.

The invention relates to an electrical ablation balloon radiofrequency catheter in the percutaneous renal artery. The electrical ablation balloon radiofrequency catheter comprises a catheter, an electrical ablation balloon and an ablation electrode plate, wherein the tail part of the catheter is provided with a connector, the head end of the catheter is provided with the electrical ablation balloon, the electrical ablation balloon is communicated with a contrast agent filling pipeline through the catheter, the contrast agent filling pipeline is arranged in the catheter and passes through the connector to be connected with a pressure pump with contrast agents, the outer surface of the electrical ablation balloon is provided with the ablation electrode plate in spiral arrangement, the ablation electrode plate is connected with a radiofrequency ablation instrument through a conducting wire, and the conducting wire is embedded in the catheter, enters the connector from the tail part of the catheter and extends out from a port of the connector. The electrical ablation balloon radiofrequency catheter has the advantages that the operation is simple and convenient, the positioning is precise, the leaning is reliable, and the manual error and the operative complications possibly generated in the operation process are reduced to the greatest degree.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods include evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

The invention discloses an electrophysiology catheter. The electrophysiology catheter comprises a catheter bendable section, a catheter main body section and a catheter handle which are connected in sequence, wherein the far end of the catheter bendable section is provided with an annular ring, a plurality of annular electrodes are distributed on the annular ring, the catheter handle is provided with a ring adjusting push button, the catheter is internally provided with a first cavity, the first cavity is provided with ring adjusting wires in a penetrating manner, and the ring adjusting wires are respectively connected with the ring adjusting push button and the far end of the annular ring. According to the electrophysiology catheter provided by the invention, the far end of the catheter bendable section is provided with the annular ring, and the push button of the catheter handle and the ring adjusting wires arranged in the catheter are used for controlling the bending shape of the far end of the catheter and the diameter of the annular ring, so that the plurality of electrodes arranged on the far end of the catheter effectively attach to the mouth part or the inner wall of the renal artery, the purpose of treating the refractory hypertension and other cardiovascular diseases, such as atrial fibrillation and catecholaminergic polymorphic ventricular tachycardia related to sympathetic nerve excessive activation is achieved, and the operation is safe and reliable.

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.

The invention belongs to the technical field of medical test instruments and particularly relates to an in-vitro simulation device for vascular intervention embolism treatment. The device comprises apulse pump, an organ artery module, a basic blood vessel module and a supporting structure, wherein the pulsation pump is used for supplying blood to the simulated heart pulsation; the organ artery module comprises a renal artery module, a hepatic artery module and a splenic artery module which are respectively used for simulating renal artery embolism, hepatic artery embolism and splenic artery embolism; the basic blood vessel module is used for simulating a basic blood vessel passage for the interventional catheter to enter the body; and the supporting structure is used for supporting and fixing the modules and maintaining the shape of blood vessels. The device is high in blood vessel reduction degree, can be modified according to the specific illness state, is transparent and visual, and can accurately simulate the embolism part and the embolism process.

The invention discloses a renal artery radiofrequency ablation catheter. The renal artery radiofrequency ablation catheter comprises a regulating assembly for regulating nerves, and the regulating assembly comprises an electrode and a bearing part for bearing the electrode; the electrode is used for transmitting regulating energy to the nerves and comprises an electrode wire wound on the bearing part, the bearing part has a first shape and a second shape, the regulating assembly is set to be suitable for moving in vessels when the bearing part is in the first shape, and the electrode is located at the position suitable for transmitting the regulating energy to the nerves when the bearing part is in the second shape. Compared with the prior art, the length that the electrode extends on the bearing part is longer, so that the renal artery radiofrequency ablation catheter has the better ablation effect.

Disclosed herein are a system and method for locating and identifying nerves innervating the wall of arteries such as the renal artery. The system identifies an area on a vessel wall innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The method includes evaluating a change in physiological parameters after energy is delivered to arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic ornone) based on the evaluated results. The system includes at least a device (101) for delivering energy to the wall of a blood vessel; a sensor (103) for detecting physiological signals from a subject; and an indicator (105) to display results obtained using said method. Also provided are catheters (2510, 2520) for performing the mapping and ablating functions.

The invention discloses an electrode catheter for quickly and accurately carrying out stimulation and ablation on sympathetic nerves on a renal artery wall by using a same catheter. An electrode catheter comprises a wire guide head inserted into a renal artery through a guide electrode catheter, a mesh basket, a pipe body, a control handle for controlling a space shape change of the mesh basket, and a connector, wherein the mesh basket is capable of adapting to full and tight contact with the inner wall of the renal artery through changing the space shape, and carrying out stimulation and ablation surgeries on renal sympathetic nerves; and the connector is used for electrically connecting a ring electrode on the mesh basket, an external stimulator and a radio frequency instrument and fixing on the tail part of the control handle. The electrode catheter is capable of carrying out electric stimulation on an inner membrane of the renal artery, mapping a point with an obvious blood pressure rise caused by the stimulation, finding out a sympathetic nerve dense region and carrying out positioning target ablation, so that more effective ablation of the sympathetic nerves on the renal artery wall is achieved. Stimulation mapping, ablation and temperature control of the renal artery can be achieved on the same ring electrode, position errors caused by replacement of various instruments in different processes are avoided and the electrode catheter is more accurate and faster.

The invention discloses a multipolar radiofrequency ablation catheter which is applicable to being used in renal artery vessels, comprising three parts of a catheter ablation working end, a main body section and a handle. The catheter ablation working end adopts a kinematic pair mechanism structure. The kinematic pair mechanism comprises a plurality of sets of single-unit front and back crank kinematic pairs. Each single-unit front and back crank kinematic pair is connected with a set of electrode tube and convex ring electrodes to constitute an independent or linked single-unit catheter ablation working end. A plurality of convex ring electrodes are evenly distributed the periphery of vessels and are closely attached to the inner wall of renal artery for mapping and ablation. The catheter of the invention has the advantages of simple and convenient operation, flexible adjustment, precise location of ablation, real-time monitoring and adjusting of ablation temperature and radio-frequency power, reducing treatment complication and lowering the surgical risk.

The invention discloses an iron-based alloy renal artery stent, and relates to the technical field of medical instruments. The iron-based alloy renal artery stent comprises a first end socket and an intermediate tube, wherein a connection large head is fixedly connected with one end of the first end socket, an inner buckle is fixedly connected with an inner wall of the connection large head, bothends of the intermediate tube are fixedly connected with connection small heads, outer buckles are fixedly connected with outer walls of the connection small heads, the inner buckle and the outer buckles are matched, and the connection large head is fixedly connected with the outer buckles on the connection small heads through the inner buckle. According to the iron-based alloy renal artery stent,by arranging the first end socket and a second end socket, after the first end socket and the second end socket, which are conical, are fixedly connected with the intermediate tube, the intermediatetube can always located in a hemadostenosis position, and due to the fact that the first end socket and the second end socket are conical, nether the first end socket nor the second end socket can gothrough the hemadostenosis position, so that the purposes of fixing the intermediate tube and preventing movement of the iron-based alloy renal artery stent in a blood vessel are achieved.

The invention discloses a composite drug intravascular stent which comprises a bare metal stent (prepared from a nickel-titanium memory alloy material), recombinant human collagen and folic acid are loaded on a stent body, HMGB1 fragment peptide and a VEGFR-2 antibody are crosslinked on the surface of the bare metal stent. Specifically, a dynamic liquid electrospinning technology is utilized to load a composite spinning solution of recombinant human collagen, folic acid, HMGBI fragment peptide and the VEGFR-2 antibody onto a nickel-titanium memory alloy bare metal stent to form an intravascular stent loaded with the recombinant human collagen and folic acid and cross-linked with the HMGBI fragment peptide and the VEGFR-2 antibody, so that EPCs capture, homing, proliferation and differentiation are promoted, and rapid endothelialization of the blood vessel is realized. The stent not only can be used for coronary stents, but also can be used for cerebrovascular stents, renal artery stents, main artery stents and the like.

The invention discloses a quality inspection body model suitable for digital subtraction angiography, and a detection method. The quality inspection body model comprises a U-shaped block, a socket module, a step module and a skeleton module which are sequentially stacked from bottom to top, wherein a jack is arranged in the socket module, a replaceable simulation module is arranged in the jack, and the replaceable simulation module comprises an artery blood vessel simulation module, a heart coronary artery simulation module, a carotid artery simulation module and a renal artery simulation module; and a resolution test module can be further placed in the socket module. The quality inspection body model further comprises a blank module and a mark module, wherein the blank module is used as a control group of the artery blood vessel simulation module and placed on the same plane with the artery blood vessel simulation module; and the mark module works cooperatively with the resolution test module. The quality inspection body model disclosed by the invention is close to a real case to a greater extent during detection because of being provided with the modules for simulating the carotid artery, renal artery and coronary artery diseases of a human body, thus more representative data is provided for quality inspection.

The invention relates to the technical field of molecular biological medical treatment, in particular to application of an atherosclerotic renal artery stenosis diagnosis molecular marker. The molecular marker is PR11-387H17.6, and the nucleotide sequence of the molecular marker is shown in SEQ ID No.1. The purpose is to provide the atherosclerotic renal artery stenosis diagnosis molecular markerPR11-387H17.6 aiming at the fact that currently and clinically, detection of atherosclerotic renal artery stenosis is lack of a diagnosis index with high sensitivity and high specificity. The application is significant in finding the atherosclerotic renal artery stenosis diagnosis molecular marker with high sensitivity and high specificity and developing a corresponding assisting diagnosis reagentor kit.

The invention discloses a medicated food for preventing and treating atherosclerosis. The medicated food is composed of the following raw materials in parts by weight: 500 to 1000 parts of crucian, 15 to 30 parts of red sage root, 5 to 10 parts of radix astragali, 5 to 10 parts of ginger, and 12 to 24 parts of jujube. The invention further discloses a preparation method and applications of the medicated food. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, is accord with the principle on treating atherosclerosis, and is capable of treating atherosclerosis effectively. The medicated food has a good effect during the preclinical phase of atherosclerosis, is capable of well preventing and treating coronary atherosclerotic cardiopathy, carotid atherosclerosis, renal atherosclerosis, and the like, and can be used to assist the therapy. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, has the advantages of fresh and delicious taste, rich nutrients, simple preparation, and low cost, is suitable for large-scale promotion and application, and has a good medical prospect.

The invention relates to a method to prevent contrast-induced nephropathy during an imaging procedure. The method includes steps of positioning balloon catheters in a patient's renal arteries and renal veins and inflating the balloons of each catheter to block the flow of contrast media into the patient's kidneys.

The invention provides a covered stent system. The covered stent system is simple in structure, clear in principle, flexible and diverse in combinations and relatively few in required stent specifications, achieves limited stent specifications and meets the requirements for different vascular anatomical structures. Various stents in a stent sub-system are fast in release, and blood flow, deep hypothermic circulatory and extracorporeal circulation do not need to be blocked, so that the surgical operation difficulty is greatly reduced, the operation time is shortened, and the perioperative mortality and complication can be greatly reduced. In addition, the operation time is shortened and the operation difficulty is reduced, so that the amount of a contrast medium can be reduced, and meanwhile, the irradiation time that a doctor and a patient are exposed to radioactive rays is significantly shortened. The covered stent system provided by the invention can achieve endovascular exclusion treatment from single-branched vessels to multibranched vessels, for example, endovascular exclusion treatment from arcus aortae and celiac trunks to renal arteries.