66 results about "Kidney arteries" patented technology

Various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue.

The present invention includes a method and apparatus to perform rapid multi-slice MR imaging without ECG gating or requiring breath-holding that is capable of renal profusion analysis and angiographic screening. An ungated interleaved pulse sequence is applied in rapid succession, followed by a delay interval. The ungated interleaved pulse sequence is repeatedly played out with the predefined delay interval between each application of the pulse sequence. The resulting images provide not only a series of temporal phases of contrast-enhanced blood uptake for renal profusion analysis, but also provide enough dynamic range to include angiographic screening of the renal arteries.

The present invention relates to an apparatus for mapping and ablating renal nerves distributed on renal arteries. The apparatus comprises a guiding catheter, a mapping and ablating catheter, a handle and a joint, wherein the guiding catheter has a front end which can control a degree of curvature of the catheter and is internally provided with at least one chamber; the mapping and ablating catheter is arranged in one chamber of the guiding catheter and is provided with one or more electrodes and one or more detection devices at the head end; the mapping and ablating catheter has a front end which has a degree of curvature, can stretch out of or retract back in the guiding catheter and is rotatable; the handle connects the guiding catheter and the mapping ablation catheter and comprises one or more control elements which are used for move the guiding catheter and the mapping ablating catheter; and the joint is used for providing energies for the electrodes.

The invention relates to an electrical ablation balloon radiofrequency catheter in the percutaneous renal artery. The electrical ablation balloon radiofrequency catheter comprises a catheter, an electrical ablation balloon and an ablation electrode plate, wherein the tail part of the catheter is provided with a connector, the head end of the catheter is provided with the electrical ablation balloon, the electrical ablation balloon is communicated with a contrast agent filling pipeline through the catheter, the contrast agent filling pipeline is arranged in the catheter and passes through the connector to be connected with a pressure pump with contrast agents, the outer surface of the electrical ablation balloon is provided with the ablation electrode plate in spiral arrangement, the ablation electrode plate is connected with a radiofrequency ablation instrument through a conducting wire, and the conducting wire is embedded in the catheter, enters the connector from the tail part of the catheter and extends out from a port of the connector. The electrical ablation balloon radiofrequency catheter has the advantages that the operation is simple and convenient, the positioning is precise, the leaning is reliable, and the manual error and the operative complications possibly generated in the operation process are reduced to the greatest degree.

The invention discloses an electrophysiology catheter. The electrophysiology catheter comprises a catheter bendable section, a catheter main body section and a catheter handle which are connected in sequence, wherein the far end of the catheter bendable section is provided with an annular ring, a plurality of annular electrodes are distributed on the annular ring, the catheter handle is provided with a ring adjusting push button, the catheter is internally provided with a first cavity, the first cavity is provided with ring adjusting wires in a penetrating manner, and the ring adjusting wires are respectively connected with the ring adjusting push button and the far end of the annular ring. According to the electrophysiology catheter provided by the invention, the far end of the catheter bendable section is provided with the annular ring, and the push button of the catheter handle and the ring adjusting wires arranged in the catheter are used for controlling the bending shape of the far end of the catheter and the diameter of the annular ring, so that the plurality of electrodes arranged on the far end of the catheter effectively attach to the mouth part or the inner wall of the renal artery, the purpose of treating the refractory hypertension and other cardiovascular diseases, such as atrial fibrillation and catecholaminergic polymorphic ventricular tachycardia related to sympathetic nerve excessive activation is achieved, and the operation is safe and reliable.

The invention belongs to the technical field of medical test instruments and particularly relates to an in-vitro simulation device for vascular intervention embolism treatment. The device comprises apulse pump, an organ artery module, a basic blood vessel module and a supporting structure, wherein the pulsation pump is used for supplying blood to the simulated heart pulsation; the organ artery module comprises a renal artery module, a hepatic artery module and a splenic artery module which are respectively used for simulating renal artery embolism, hepatic artery embolism and splenic artery embolism; the basic blood vessel module is used for simulating a basic blood vessel passage for the interventional catheter to enter the body; and the supporting structure is used for supporting and fixing the modules and maintaining the shape of blood vessels. The device is high in blood vessel reduction degree, can be modified according to the specific illness state, is transparent and visual, and can accurately simulate the embolism part and the embolism process.

The invention discloses a renal artery radiofrequency ablation catheter, which includes an adjustment assembly for adjusting the nerve, the adjustment assembly includes an electrode and a bearing part for carrying the electrode, the electrode is used for transmitting adjustment energy to the nerve, the electrode includes a An electrode wire on a carrier member having a first shape in which the modulating assembly is configured to move within a blood vessel and a second shape in which the electrode is in a shape suitable for delivering modulating energy to the nerve s position. Compared with the prior art, the extension length of the electrode on the bearing part is longer, which makes the renal artery radiofrequency ablation catheter of the present invention have better ablation effect.

The invention discloses an electrode catheter for quickly and accurately carrying out stimulation and ablation on sympathetic nerves on a renal artery wall by using a same catheter. An electrode catheter comprises a wire guide head inserted into a renal artery through a guide electrode catheter, a mesh basket, a pipe body, a control handle for controlling a space shape change of the mesh basket, and a connector, wherein the mesh basket is capable of adapting to full and tight contact with the inner wall of the renal artery through changing the space shape, and carrying out stimulation and ablation surgeries on renal sympathetic nerves; and the connector is used for electrically connecting a ring electrode on the mesh basket, an external stimulator and a radio frequency instrument and fixing on the tail part of the control handle. The electrode catheter is capable of carrying out electric stimulation on an inner membrane of the renal artery, mapping a point with an obvious blood pressure rise caused by the stimulation, finding out a sympathetic nerve dense region and carrying out positioning target ablation, so that more effective ablation of the sympathetic nerves on the renal artery wall is achieved. Stimulation mapping, ablation and temperature control of the renal artery can be achieved on the same ring electrode, position errors caused by replacement of various instruments in different processes are avoided and the electrode catheter is more accurate and faster.

The invention discloses a multipolar radiofrequency ablation catheter which is applicable to being used in renal artery vessels, comprising three parts of a catheter ablation working end, a main body section and a handle. The catheter ablation working end adopts a kinematic pair mechanism structure. The kinematic pair mechanism comprises a plurality of sets of single-unit front and back crank kinematic pairs. Each single-unit front and back crank kinematic pair is connected with a set of electrode tube and convex ring electrodes to constitute an independent or linked single-unit catheter ablation working end. A plurality of convex ring electrodes are evenly distributed the periphery of vessels and are closely attached to the inner wall of renal artery for mapping and ablation. The catheter of the invention has the advantages of simple and convenient operation, flexible adjustment, precise location of ablation, real-time monitoring and adjusting of ablation temperature and radio-frequency power, reducing treatment complication and lowering the surgical risk.

The invention discloses a composite drug intravascular stent which comprises a bare metal stent (prepared from a nickel-titanium memory alloy material), recombinant human collagen and folic acid are loaded on a stent body, HMGB1 fragment peptide and a VEGFR-2 antibody are crosslinked on the surface of the bare metal stent. Specifically, a dynamic liquid electrospinning technology is utilized to load a composite spinning solution of recombinant human collagen, folic acid, HMGBI fragment peptide and the VEGFR-2 antibody onto a nickel-titanium memory alloy bare metal stent to form an intravascular stent loaded with the recombinant human collagen and folic acid and cross-linked with the HMGBI fragment peptide and the VEGFR-2 antibody, so that EPCs capture, homing, proliferation and differentiation are promoted, and rapid endothelialization of the blood vessel is realized. The stent not only can be used for coronary stents, but also can be used for cerebrovascular stents, renal artery stents, main artery stents and the like.

The invention discloses a quality inspection body model suitable for digital subtraction angiography, and a detection method. The quality inspection body model comprises a U-shaped block, a socket module, a step module and a skeleton module which are sequentially stacked from bottom to top, wherein a jack is arranged in the socket module, a replaceable simulation module is arranged in the jack, and the replaceable simulation module comprises an artery blood vessel simulation module, a heart coronary artery simulation module, a carotid artery simulation module and a renal artery simulation module; and a resolution test module can be further placed in the socket module. The quality inspection body model further comprises a blank module and a mark module, wherein the blank module is used as a control group of the artery blood vessel simulation module and placed on the same plane with the artery blood vessel simulation module; and the mark module works cooperatively with the resolution test module. The quality inspection body model disclosed by the invention is close to a real case to a greater extent during detection because of being provided with the modules for simulating the carotid artery, renal artery and coronary artery diseases of a human body, thus more representative data is provided for quality inspection.

The invention relates to the technical field of molecular biological medical treatment, in particular to application of an atherosclerotic renal artery stenosis diagnosis molecular marker. The molecular marker is PR11-387H17.6, and the nucleotide sequence of the molecular marker is shown in SEQ ID No.1. The purpose is to provide the atherosclerotic renal artery stenosis diagnosis molecular markerPR11-387H17.6 aiming at the fact that currently and clinically, detection of atherosclerotic renal artery stenosis is lack of a diagnosis index with high sensitivity and high specificity. The application is significant in finding the atherosclerotic renal artery stenosis diagnosis molecular marker with high sensitivity and high specificity and developing a corresponding assisting diagnosis reagentor kit.

The invention discloses a medicated food for preventing and treating atherosclerosis. The medicated food is composed of the following raw materials in parts by weight: 500 to 1000 parts of crucian, 15 to 30 parts of red sage root, 5 to 10 parts of radix astragali, 5 to 10 parts of ginger, and 12 to 24 parts of jujube. The invention further discloses a preparation method and applications of the medicated food. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, is accord with the principle on treating atherosclerosis, and is capable of treating atherosclerosis effectively. The medicated food has a good effect during the preclinical phase of atherosclerosis, is capable of well preventing and treating coronary atherosclerotic cardiopathy, carotid atherosclerosis, renal atherosclerosis, and the like, and can be used to assist the therapy. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, has the advantages of fresh and delicious taste, rich nutrients, simple preparation, and low cost, is suitable for large-scale promotion and application, and has a good medical prospect.

The invention relates to a method to prevent contrast-induced nephropathy during an imaging procedure. The method includes steps of positioning balloon catheters in a patient's renal arteries and renal veins and inflating the balloons of each catheter to block the flow of contrast media into the patient's kidneys.

The invention provides a covered stent system. The covered stent system is simple in structure, clear in principle, flexible and diverse in combinations and relatively few in required stent specifications, achieves limited stent specifications and meets the requirements for different vascular anatomical structures. Various stents in a stent sub-system are fast in release, and blood flow, deep hypothermic circulatory and extracorporeal circulation do not need to be blocked, so that the surgical operation difficulty is greatly reduced, the operation time is shortened, and the perioperative mortality and complication can be greatly reduced. In addition, the operation time is shortened and the operation difficulty is reduced, so that the amount of a contrast medium can be reduced, and meanwhile, the irradiation time that a doctor and a patient are exposed to radioactive rays is significantly shortened. The covered stent system provided by the invention can achieve endovascular exclusion treatment from single-branched vessels to multibranched vessels, for example, endovascular exclusion treatment from arcus aortae and celiac trunks to renal arteries.

A renal sympathetic nerve ablation system comprises a main body module, a developing module and an ablation module; the main body module comprises a control handle with an ablation catheter inlet and a main body tube which is arranged on the control handle and is internally provided with an ablation catheter passage; the developing module comprises an endoscope camera, an endoscope light source and a circuit board with a developing module control assembly; the ablation module comprises an ablation catheter and an ablation catheter control device which are connected with each other; and the ablation catheter is inserted into and penetrates through the ablation catheter passage. The renal sympathetic nerve ablation system in the invention can directly act on renal sympathetic nerves instead of being conducted through a blood vessel wall; the ablation effect is remarkably improved under the condition that energy consumption is greatly reduced; and damage to the renal artery blood vessel is greatly reduced.

The invention relates to the technical field of medical instruments, in particular to a renal artery microwave ablation needle. According to the specific technical scheme, the renal artery microwave ablation needle comprises an outer tube with one closed end and one open end, a needle tube arranged in the outer tube in a sleeved mode and a cable arranged in the needle tube, an electrode adjusting device is arranged in the outer tube and close to the closed end of the outer tube, and an electrode is fixed to the electrode adjusting device. The side wall of the outer tube is provided with an arc-shaped hole for the electrode to stretch out, one end of the needle tube is provided with a circular-truncated-cone-shaped connector, and the circular-truncated-cone-shaped connector is matched with an electrode adjusting device. And under the action of the circular-truncated-cone-shaped connector, the electrode gradually extends out of the outer pipe. The problem that the distance between the electrode and the inner wall of the renal artery cannot be adjusted in real time in the prior art is solved.

The invention provides an interventional renal artery sympathetic nerve activity detection system. The system comprises an interventional catheter, a various-blood detection sensor and blood analysis and detection equipment, an interventional end structure of the interventional catheter is communicated with a catheter, and chemical substances are conveyed to a preset position through the interventional end structure, wherein renal artery sympathetic nerves sense the concentration of the input chemical substances and then feed back through a RAAS system so as to secrete and form related blood to be detected; the various-blood detection sensor is arranged on the interventional catheter and close to the interventional end structure of the interventional catheter, and the various-blood detection sensor is used for detecting the blood to be detected to form detection signals; and the blood analysis and detection equipment is connected with the blood detection sensor and is used for receiving the detection signals and analyzing various signals of the blood to be detected to form corresponding physicochemical indexes reflecting the activity of the renal artery sympathetic nerves. The technical scheme has the beneficial effects that the activity of the renal artery sympathetic nerves can be accurately determined through the cooperative operation of the whole set of system.

The invention relates to a modular stent with branches for treating thoracoabdominal aortic aneurysm, and belongs to the technical field of medical instruments. The stent is a covered stent and comprises a descending aorta region near-end anchoring module, a visceral artery region branch graft module and an abdominal aorta region far-end anchoring module which are communicated in sequence; the number of the descending aorta area near-end anchoring module is at least one. The invention provides a modular endovascular graft with branches for treating thoracico-abdominal aortic aneurysm of Asian people. Through modularization and different combination modes, anatomical structures of various thoracico-abdominal aortic aneurysms can be adapted, and the time required by customization can be effectively avoided; visceral arteries and renal arteries can be reconstructed through branches; sufficient friction force is provided for graft anchoring and bridging through combined anchoring, branch selection is facilitated through a guide wire guiding area, and operation difficulty and the time are reduced. Therefore, the thoracico-abdominal aortic aneurysm is effectively treated, the operation time is shortened, and adverse reactions of contrast agents are reduced.