8results about "DNA computers" patented technology

Methods, systems, and devices for encoding data for storage in genetic material are disclosed. For example, a computing system can segment user data into a plurality of data blocks and generate seed data characterizing a plurality of fountain code seeds. Additionally, the computing system can, for each data block, implement a set of operations to generate one or more data packets. In some instances, the set of operations can include, for each of the plurality of fountain code seeds, determining a bit value and a corresponding meta code value, and determining which of the fountain code seeds has a meta code value for the bit value that matches a value for the bit position identified in the metadata. Furthermore, the computing system can, for each data packet, cause implementation of a second set of operations to synthesize a polynucleotide strand from at least the bit values of the corresponding data packet.

Provided are a method and system for storing information using DNA. The method comprises: 1) obtaining a DNA fragment attribute library, wherein the DNA fragment attribute library comprises a plurality of DNA molecules, and comprises a retrieval table of storage object attributes and the DNA molecules, and each DNA molecule comprises double-stranded DNA, which represents the storage object attribute, and a single-stranded sticky end for connection; 2) on the basis of the retrieval table, encoding information to be stored, so that same is directly mapped to a corresponding DNA molecule in the DNA fragment attribute library; 3) acquiring corresponding DNA fragments from the DNA fragment attribute library, and connecting same, so as to obtain a connected DNA molecule; and 4) storing the connected DNA molecule. The method and system can be extended to different data types and different application scenarios, and prevent an oligonucleotide sequence from being repeatedly synthesized during storage, thereby greatly reducing storage cost.

A computer implemented system and process to determine a model for a domain includes identifying a schema that defines a possible causal element of a particular type of behavior. One or more concepts are determined, as well as one or more sub-concepts for each concept, where each concept and sub-concept are associated with a logical relationship. Multiple models are determined from the one or more concepts and the one or more sub-concepts. The multiple models may be calibrated using representative data collected from a real-world source. An optimal model is determined amongst a plurality of calibrated models.

The application provides a method for building a 9-bit parity check molecular switch circuit, and the steps are as follows: based on DNA strand displacement technology, the structure and reaction mechanism of the molecular switch circuit are described; the reaction rate and leakage rate are set, and the input signal of the molecular switch circuit and the concentration ratio of the molecular switch at each stage are optimized; the fan-in molecular switch circuit and the fan-out molecular switch circuit are set according to the molecular switch circuit; the 3-bit parity check molecular switch circuit is built based on the fan-in molecular switch circuit and the fan-out molecular switch circuit by using the switch canvas routing strategy, the 9-bit parity check molecular switch circuit is built by using three 3-bit parity check molecular switch circuits with the same structure; and the correctness of the 9-bit parity check molecular switch circuit is verified by using a Simbiology simulation platform. In the construction of a large-scale complex logic circuit, the application has a simple and unified DNA chain structure, a fast reaction speed and good stability, and provides a new scheme for the construction of a modular DNA circuit.

Methods and systems for sequence-controlled polymer encoding, decoding, and storage are provided. In various embodiments, input data is encoded into one or more sequence controlled polymer, wherein encoding the input data comprises applying an error-correction code. The one or more sequence-controlled polymer are synthesized. The synthesized one or more sequence- controlled polymer are encapsulated in a plurality of particles. The plurality of particles are embedded into a feedstock.

Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.) The compositions, devices, systems and methods described herein provide improved storage, density, and retrieval of biomolecule-based information.

A DNA movable type storage system and method based on movable type printing including: (1) construct a physical DNA movable type library of data payloads and a physical DNA movable type library of indexes based on “DNA movable type codebook”, which consist of a variety of DNA oligonucleotides corresponding to all “DNA payload movable type elements” and “DNA index movable type elements” in the two libraries, respectively; (2) transcode from the storage binary data into corresponding “DNA movable type units”, each of which contains corresponding DNA payload movable type elements and related DNA index movable type elements; (3) link the abovementioned DNA payload and index movable type elements to form a physical “DNA movable type unit”, and put all generated DNA movable type units together for DNA storage, which cover all data information of the target file.

The embodiment of the present disclosure discloses a soft decision information decoding method and encoding method for DNA storage. The soft decision information decoding method for DNA storage comprises: clustering sequencing sequences in obtained sequencing data; obtaining a consensus sequence for each cluster to obtain a plurality of consensus sequences, taking the support degree of multiple sequence alignment recorded by each base in the consensus sequence as the quality value of each base on the consensus sequence; arranging the plurality of consensus sequences according to sequence indexes to obtain a decoding matrix block; and decoding the decoding matrix block. By obtaining a consensus sequence for the sequencing sequence, most random errors are removed, and then the support degree of multiple sequence alignment is used to predict and sort the remaining errors, so that the sequencing information is fully mined to improve the prediction accuracy and reduce the calculation complexity of prediction. The soft decision decoding can greatly improve the error correction capability, so that the DNA storage can be applied to a larger data scale and has stronger fidelity.