The present application relates to a kind of
antibody viscosity prediction method and its application, the method includes: (1) extracting physical and chemical characteristics from the variable region sequence and structure of
antibody;The physical and chemical characteristics include net charge, hydrophobicity, DeepSCM
space charge chart
score, space aggregation attribute based on DeepSP prediction, local SCM based on DeepSP prediction, surface hydrophobic region, positive charge region,
negative charge region, variable region charge symmetry parameter and length parameter;(2) the features and
viscosity value extracted in step (1) are used to
train viscosity prediction model;(3) the viscosity prediction model obtained in step (2) is used for prediction;The viscosity judgment method is: greater than 20 cP, high viscosity, less than or equal to 20 cP, low high viscosity.The present application extracts 43 physical and chemical characteristics from the variable region sequence and structure of
antibody, and the accuracy of detection is greatly improved compared with the existing prediction method by the viscosity prediction model obtained by training.