The invention discloses medical organic silicon quaternary ammonium salt antibacterial agent modified PP and a preparation method thereof. The modified PP is prepared through the following steps: weighing the following components: PP, zinc stearate, an organic silicon quaternary ammonium salt antibacterial agent, sodium benzoate, LDPE, calcium carbonate, an antioxidant, phosphite ester, polybutadiene, barium stearate, an ultraviolet ray absorbent, calcium stearate, a styrene thermoplasticity elastomer, CPE and carbon black in parts by weight, uniformly mixing the weighed components, and extruding and pelleting the uniformly-mixed components so as to obtain the modified PP. The PP has the advantages that the impact strength is 3.5-5.5 kJ/m<2>, elasticity modulus is 2-4 GPa, the antibacterial rate for escherichia coli is 85-95%, the antibacterial rate for golden staphylococcus is 95-99%, the bacteriostasis rate for pseudomonas aeruginosa is 97.5-99.5%, the bacteriostasis rate for salmonella typhimurium and Klebsiella pneumoniae is 92-96%, and the bactericidal rate for sarcina is 90-95%.