33results about How to "Slow degradation rate" patented technology

The invention relates to a fully-degradable high-barrier composite material for flexible package, which is mainly prepared by blending the following components in parts by weight: 100 parts of a biodegradable matrix resin, 0-30 parts of an inorganic filler, and 0.1-15 parts of auxiliary agent; preferably, the composite material is formed by double-layer co-extrusion compounding of an inner layer biodegradable matrix resin and an outer layer biodegradable matrix resin; the inner layer biodegradable matrix resin is prepared from the following components in parts by weight: 10 to 90 parts of PBAT, 10 to 90 parts of PCL and 0.1 to 5 parts of an auxiliary agent, and the total weight part of PBAT and PCL is 100 parts; the outer layer biodegradable matrix resin is prepared from the following components in parts by weight: 10 to 90 parts of PBAT, 10 to 90 parts of PLA, 1 to 20 parts of an inorganic filler and 0.1 to 8 parts of an auxiliary agent, and the total weight part of PBAT and PLA is 100 parts, and the inorganic filler is nano calcium carbonate or talcum powder.

The invention discloses a pH sensitive medical polyurethane urea material and a preparation method thereof. The preparation method comprises the following steps: mixing a terminal dihydroxypyridine compound and a double-end hydroxyl polyethylene glycol to obtain polyurethane urea, and dissolving by adding N,N-dimethylformamide, carrying out chain extension in the presence of urea-containing diisocyanate, and purifying to obtain pH-sensitive polyurethane urea, wherein diisocyanate is L-lysine diisocyanate-1,4-butylenediamine-L-lysine diisocyanate. The pyridine group on a side chain of polyurethane urea is Lewis base, which is able to decompose hydrogen bonds in a polyurethane urea network under acidic conditions, resulting in discontinuous volume expansion of material. According to the invention, H<+> is removed under neutral or alkaline conditions, and N on a pyridine ring and NH on carbamate or ureido form a hydrogen bond, approximating a network structure, so that the polyurethane urea molecular chain shrinks and the swelling degree decreases remarkably. Therefore, by controlling the change of the pH of a medium, the degree of swelling of polyurethane urea can be effectively controlled.

The invention discloses a modification method used for the surface of a magnesium alloy stent and contains controlledly degradable magnesium alloy stent surface micro-arc oxidation modification treatment and drug molecule biomimetic deposition; the magnesium alloy stent surface micro-arc oxidation modification treatment is first performed on the surface of magnesium alloy stent substrate to form controlledly degradable microporous ceramic oxide film with high porosity, the thickness of the film is 80-120mu m, the porosity is 20-40%; then drug molecule biomimetic deposition capable of promoting endothelial growth or dissolving thrombus and anticoagulating is performed on the microporous ceramic oxide film and the width of the settled layer is 5-10mu m. The modification of the surface of the magnesium alloy stent of the invention can effectively improve the in vivo biodegradation rate of the stent and the corresponding consistency of the mechanical property thereof, increase the compatibility between the stent and vascular walls, reduce the restenosis rate of blood vessels, lower the incidence of complications of patients and improve the survival rate and the life quality.

The invention relates to a 3D-printed degradable macromolecular scaffold and photo-crosslinked hydrogel composite scaffold. The 3D-printed degradable macromolecular scaffold and photo-crosslinked hydrogel composite scaffold comprises a 3D-printed degradable macromolecular scaffold, wherein the interior of the 3D-printed degradable macromolecular scaffold comprises photo-crosslinked hydrogel with high substitution degree and photo-crosslinked hydrogel with low substitution degree, the photo-crosslinked hydrogel with high substitution degree is crosslinked with the photo-crosslinked hydrogel with low substitution degree, and preferably, a polycaprolactone (PCL) scaffold and methacrylic anhydride gelatin (GelMA) with different substitution degrees are crosslinked and compounded. In the composite scaffold, the 3D-printed degradable macromolecular scaffold has good mechanical properties; the photo-crosslinked hydrogel with high substitution degree has high crosslinking degree, can form a fiber network and micropores, and well supports cells; and the photo-crosslinked hydrogel with low substitution degree has multiple active sites, is beneficial to cell adhesion growth, and can adsorb alarge amount of nutrient solution. Through cooperation of the 3D-printed degradable macromolecular scaffold, the photo-crosslinked hydrogel with high substitution degree and the photo-crosslinked hydrogel with low substitution degree, the composite scaffold is suitable for cell growth and vascularization from an inner layer to an outer layer, and when the composite scaffold is used for medical human body repair, scaffold integration is realized to promote regeneration of new tissues.

The invention provides a manufacturing method of a composite material metal bone implant with a structural function. The method comprises the following steps that bone defect image data are imported into a computer and are processed, and a three-dimensional model of a filling bone implant is established; according to the requirements of bone repairing, fixing and resetting, reliable bearing and bone healing promotion, the bone implant is divided into functional areas with different bearing and degradation characteristics, corresponding alloys are adopted for implant material design, pore units with different porosities are adopted for implant internal structure design, and three-dimensional models of parts in the different functional areas are established on the basis of considering assembling and surgical operations; the three-dimensional models of the different functional areas are subdivided, printing parameters are set according to materials and structures, printing data of all section contours are obtained, and the printing data are input into a laser powder bed fusion printer; and parts of the different functional areas are printed on the basis of the printing data, and alloy powder is printed and formed in a layer-by-layer powder feeding and layer-by-layer laser scanning melting and solidifying mode.

The invention discloses a foam board which comprises the following components in parts by weight: 60-100 parts of polylactic acid, 30-50 parts of polyethylene, 6-17 parts of polyethylene glycol ether,2-8 parts of polyester polyol, 5-16 parts of polyester resin, 6-18 parts of starch, 1-5 parts of a foam stabilizer, 2-6 parts of a seaweed extract, 1-4 parts of silicone oil, 3-5 parts of high bauxite, 8-15 parts of ethylene-vinyl acetate, 0.5-3 parts of expanded graphite, 3-7 parts of bamboo fiber, 1-4 parts of magnesium carbonate and 0.2-0.5 part of a stabilizer. The preparation method comprises the steps of mixing, ultrasonic treatment, pre-foaming, extrusion and the like. The foam board is low in degradation rate and long in service life, generated degradation products are almost harmlessto human bodies and the environment, and the foam board has good structural strength and fireproof performance.

The invention discloses a pH-sensitive biodegradable polyurethane-urea material and a preparation method thereof. The polyurethane-urea is pH-sensitive biodegradable polyurethane-urea prepared by mixing dihydroxy-terminal polyether ester with N,N-bis(2-ethoxy) 4-pyridinccarbox amide, carrying out chain expansion by using carbamido-containing diisocyanate and purifying; the polyether ester is usedas a main soft segment, a chain segment containing carbamido and urethane group is used as a hard segment and a pyridine ring is positioned on a side chain. The polyurethane-urea has the characteristics of biodegradability, absorbability of a degradation product, pH sensitivity, high expanding and degrading rate in acidic mediums, as well as basically no expansion and low degrading rate in neutraland alkaline mediums; in addition, the pH sensitivity is not basically affected by temperature and can be applied to the field of controlled release as a drug carrier, and further the drug release rate is controlled according to pH values of different parts of an organism. The hard segment formed by carbamido-containing structure diisocyanate contains dense hydrogen bonds, so that the mechanicalproperty of the material is improved.

The invention relates to a nano-calcium plastic biodegradation composite resin. The composite resin is prepared from 0.5 to 20% of KV-environment-friendly plastic biodegradation cellulose and 80 to 99.5% of a nano-calcium modified plastic composite material, and under the condition of 100 to 130 DEG C, granulation via plastic extrusion is performed by mixing and stirring at 150 to 200rpm; then 1 to 65% of particles manufactured and 35 to 99% of polyethylene, polyvinyl chloride or polypropylene are mixed, and different degradable plastic products can be prepared. According to the composite resin, biological waste and natural calcium carbonate are taken as main raw materials, the distribution is wide, and the resources are rich; the preparing operation of the composite resin is simple and convenient, an original process does not need to be changed, and a plasticizer is not used; the degradability is controllable, a product only needs simple packaging, and can be stored for 3 years in a dry and lucifugal condition, the storage cost is low, and the production cost is equivalent to that of a common plastic product; compared with the prior art, the product performance is improved obviously and the composite resin has no toxicity, so that the composite resin is suitable for preparation of degradable plastic products which take polyethylene, polyvinyl chloride and polypropylene as raw materials, the quality and flexibility of the products are improved, and the degradable plastics are favorably used widely.

The invention relates to a fully degradable high-barrier composite material for flexible packaging, which is mainly prepared by blending the following components in parts by weight: 100 parts of biodegradable matrix resin; 0-30 parts of inorganic filler; 0.1-15 parts of auxiliary agent share. Preferably, the composite material is composed of an inner biodegradable matrix resin and an outer biodegradable matrix resin through double-layer co-extrusion. In parts by weight, the inner biodegradable matrix resin includes: 10-90 parts of PBAT, 10-90 parts of PCL, 0.1-5 parts of auxiliary agents, wherein the total parts by weight of PBAT and PCL is 100 parts; Said outer layer biodegradable matrix resin comprises: 10-90 parts of PBAT, 10-90 parts of PLA, 1-20 parts of inorganic filler, 0.1-8 parts of auxiliary agent; wherein, the total parts by weight of PBAT and PLA is 100 parts; all The inorganic filler is nanometer calcium carbonate or talcum powder.

The invention provides a soft tissue repair patch material, a soft tissue repair patch and a manufacturing method and application of the soft tissue repair patch, and relates to the technical field of biological tissue repair. The soft tissue repair patch material comprises sodium alginate / graphene hydrogel and fibrous protein / graphene hydrogel, wherein the sodium alginate / graphene hydrogel has certain mechanical strength and is low in degradation rate, and the defects that the mechanical property of the fibrous protein / graphene hydrogel is insufficient and the degradation rate is too high can be overcome; therefore, enough mechanical support and tissue repair time are provided for a prepared soft tissue repair patch, the fibrous protein / graphene hydrogel is beneficial to mass amplification and propagation of cells, soft tissue repair is promoted, and through cooperative use of the two hydrogel systems, the soft tissue repair patch prepared from the soft tissue repair patch material is endowed with mechanical properties suitable for clinical use, a degradation rate matched with tissue repair and good cell compatibility, and has a wide clinical application prospect.

The invention provides controllable self-crosslinking sulfhydrylated hyaluronic acid-collagen composite hydrogel as well as a preparation method therefore. The composite hydrogel is prepared from hyaluronic acid hydrogel and I-type collagen or II-type collagen; the I-type collagen or II-type collagen is distributed in a three-dimensional crosslinking network structure. The composite hydrogel has rigidity and elasticity, is high in mechanical property, can promote spreading growth of cartilage cells, is favorable for phenotype maintaining for cells, can relieve the shortcomings that an existinggel material for cartilage reparation is easy to shrink and low in cell adhesion, and has an important application value in the field of cartilage injury reparation.

The invention relates to high-volume-fraction biological magnesium alloy of an LPSO structure and a preparation method. The biological magnesium alloy comprises the following components by mass percent: 3.6 to 4.9 percent of Gd, 0.6 to 0.9 percent of Zn, 0.3 to 0.6 percent of Zr and the balance of Mg and inevitable impurities. The preparation method comprises the steps: placing the well-prepared raw materials into a crucible with protection gas to be smelted and cast to form cast ingot, placing the cast ingot after being solidified into the water to be rapidly cooled, and then placing the cast ingot into a resistance furnace with a protection atmosphere to be thermally treated, wherein the thermal treatment temperature is 340 to 460 DEG C, and the heat preserving time is 1h to 6h. The magnesium alloy has the LPSO structure with the volume fraction being greater than 30 percent, the alloy of the structure is excellent in degradability, and the problems of the biologically degradable magnesium alloy in a human body environment that the degradation speed is high and the degradation is non-uniform can be effectively solved; moreover, the alloy is toxicity-free to the cells and expected to be applied to the biomedicine field.

The invention relates to a fully absorbed Mg-Zn-Ag based amorphous medical implant base material with strong corrosion resistance, high strength and good biocompatibility, and also provides its preparation method and application. The fully absorbed Mg The -Zn-Ag based amorphous medical implant substrate is made of a Mg-Zn-Ag amorphous alloy having the following composition consisting of the following composition in the following atomic percentages Composition: silver 0%-10%, and the silver content is not 0%, zinc 15%-40%, impurity 0%-5%, and the balance is magnesium. The fully absorbed Mg-Zn-Ag based amorphous medical implant substrate of the present invention has excellent mechanical strength and hardness, low gas release during use, and slow degradation rate in the human body, and is suitable as a biodegradable implant in the human body. Implant materials are used to prepare components, components or devices used in the diagnosis, treatment, and repair of living organisms, and are used to prepare artificial tissues and artificial organs that replace damaged tissues and organs of living organisms, etc., and have broad market application prospects .

The invention adopts the copolymerization of dibasic fatty acid and dimer acid to prepare the carrier of hydrophilic anti-inflammatory drug and antitumor drug: polyanhydride. Because the polyanhydride material uses a diacid with a long carbon chain as a monomer, the degradation rate is slow and the drug release period is long, so it is suitable for the local sustained release drug treatment of osteomyelitis and solid tumor diseases.

The invention discloses a degradable iron, zinc and magnesium-based gradient composite material based on biological bone healing. A zinc layer and an iron layer are sequentially arranged on the surface of a magnesium matrix, and the thickness or the diameter of the magnesium matrix is 30-90% of bone dimension in the repaired part. The thicknesses of the zinc and iron layers are respectively determined according to the corrosion rates of zinc and iron in an in vitro simulated body fluid. According to the composite material, rigid fixation in early stage is realized to promote bone healing, the composite material is gradually degraded, use of the material with lower rigidity is transited to dynamic fixation, and finally, the material is fully absorbed in vivo to prevent from being taken out in the second operation. Rapid degradation in the non-mechanical bearing later stage is realized, and growth by differentiation of bone cells and ingrowth of blood vessels on the surface of material are induced by hoping to combine the advantages that iron in higher rigidity in the early stage realizes rigid fixation and zinc in lower rigidity in the middle stage realizes dynamic fixation by means of quicker corrosion rate of magnesium. Finally, the composite material is fully absorbed, so as to realize the bone repairing purpose. The composite material disclosed by the invention is applicable to gradient structure designs of internal fixing materials after fracture with change demands on mechanical property with the passage of time.

The invention discloses a biodegradable emamectin benzoate microsphere and a preparation method thereof. The emamectin benzoate is used as an active substance, that is, a core material; the biodegradable The material is a ball-forming material, that is, the wall material, which has the advantages of safety, low toxicity, high efficiency, long-lasting effect and good stability. Compared with the current multi-purpose polymer wall material microcapsules, it has good environmental compatibility, The advantage of good mechanical properties of the material; at the same time, by changing the ratio of polylactic acid and polypropylene carbonate in the wall material, the slow-release performance and particle size of the microspheres can be adjusted and controlled, which not only improves its drug release performance, but also improves Its environmental friendliness reduces the production cost and meets the requirements of pollution-free agricultural production.

The invention relates to a fully-absorbed Mg-Zn-Ag-based amorphous alloy with strong corrosion resistance, high strength and good biocompatibility and a preparation method thereof. The alloy is composed of the following components in the following atomic percentages : Silver 0%‑10%, and the silver content is not 0; zinc 15%‑40%; impurity 0%‑5%; the balance is magnesium. The fully absorbed Mg-Zn-Ag series amorphous alloy of the present invention has excellent mechanical strength and hardness, low gas release, strong corrosion resistance, and can be gradually absorbed by the human body as the damaged tissue heals after being implanted into the human body. It can be absorbed and degraded without secondary surgery, and it is an excellent choice as a degradable implant material in the human body, and has broad application prospects.

The invention discloses a pH sensitive medical polyurethane urea material and a preparation method thereof. The preparation method comprises the following steps: mixing a terminal dihydroxypyridine compound and a double-end hydroxyl polyethylene glycol to obtain polyurethane urea, and dissolving by adding N,N-dimethylformamide, carrying out chain extension in the presence of urea-containing diisocyanate, and purifying to obtain pH-sensitive polyurethane urea, wherein diisocyanate is L-lysine diisocyanate-1,4-butylenediamine-L-lysine diisocyanate. The pyridine group on a side chain of polyurethane urea is Lewis base, which is able to decompose hydrogen bonds in a polyurethane urea network under acidic conditions, resulting in discontinuous volume expansion of material. According to the invention, H<+> is removed under neutral or alkaline conditions, and N on a pyridine ring and NH on carbamate or ureido form a hydrogen bond, approximating a network structure, so that the polyurethane urea molecular chain shrinks and the swelling degree decreases remarkably. Therefore, by controlling the change of the pH of a medium, the degree of swelling of polyurethane urea can be effectively controlled.