A kind of biodegradable emamectin benzoate microspheres

A technology of methylamino abamectin and benzoate, applied in the field of pesticides, can solve the problems of material loss of complete biodegradation and poor compatibility, and achieve the effects of prolonging effective control time, reducing particle size and reducing pollution

Inactive Publication Date: 2017-08-11
FUJIAN AGRI & FORESTRY UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If it is blended with non-degradable polymers, the material will lose its complete biodegradability; if PLA and other aliphatic polyesters such as polycaprolactone (PCL), polydibutyl succinate (PBS) , poly 3-hydroxybutyrate (PHB) blend, although it can maintain complete biodegradability, but due to poor compatibility

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of biodegradable emamectin benzoate microspheres
  • A kind of biodegradable emamectin benzoate microspheres
  • A kind of biodegradable emamectin benzoate microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0030] (1) Preparation of drug-containing oil phase suspension: mix 0.3000g emamectin benzoate technical drug with 0.3g PLA / PPC (mass ratio 4 / 6), add 7mL dichloromethane, ice-water bath dissolved in medium to obtain a drug-containing oil phase suspension; wherein, the active ingredient in the original drug of emamectin benzoate accounts for 95.8%;

[0031] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil phase suspension in step (1) into 100 mL of PVA-1788 aqueous solution under the condition of uniform dispersion of milk, wherein, PVA-1788 The content in the aqueous solution is 10 mg / ml, and the O / W primary emulsion is prepared; the emulsification conditions are: the temperature is 30°C, the dispersion speed is 7000rpm, and the emulsification time is 5min;

[0032] (3) Preparation of microspheres: Stir the primary ...

Embodiment 2

[0035] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0036] (1) Preparation of medicinal oil phase suspension: mix 0.3000g emamectin benzoate technical drug with 0.9000g PLA / PPC (mass ratio 6 / 4, add 10 mL dichloromethane, ice-water bath dissolved in medium to obtain a drug-containing oil phase suspension; wherein, the active ingredient in the original drug of emamectin benzoate accounts for 95.8%;

[0037] (2) Preparation of primary emulsion: use a high-speed homogenizer to inject the drug-containing oil-phase suspension in step (1) into 100 mL of aqueous gum arabic solution under the condition of homogenous emulsion dispersion, wherein the gum arabic gum in the aqueous solution O / W primary emulsion was prepared with the content of 7.5 mg / ml in it; the emulsification conditions were: temperature 30 ℃, dispersion speed 10000 rpm, emulsification time 1.5 min;

[0038] (3) Preparation of microspheres: Pour all the primary ...

Embodiment 3

[0041] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0042] (1) Preparation of drug-containing oil phase suspension: mix 0.6000g emamectin benzoate technical drug with 0.3000g PLA / PPC (mass ratio 8 / 2), add 10mL dichloromethane, and put in an ice-water bath dissolved in medium to obtain a drug-containing oil phase suspension; wherein, the active ingredient in the original drug of emamectin benzoate accounts for 95.8%;

[0043] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil-phase suspension in step (1) into 100 mL of PVA-1788 aqueous solution under the condition of homogeneous emulsion dispersion, wherein, PVA-1788 The content in the aqueous solution is 10 mg / ml, and the O / W primary emulsion is prepared; the emulsification conditions are: the temperature is 30°C, the dispersion speed is 8000 rpm, and the emulsification time is 4 minutes;

[0044] (3) Preparation of mi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a biodegradable emamectin benzoate microsphere and a preparation method thereof. The emamectin benzoate is used as an active substance, that is, a core material; the biodegradable The material is a ball-forming material, that is, the wall material, which has the advantages of safety, low toxicity, high efficiency, long-lasting effect and good stability. Compared with the current multi-purpose polymer wall material microcapsules, it has good environmental compatibility, The advantage of good mechanical properties of the material; at the same time, by changing the ratio of polylactic acid and polypropylene carbonate in the wall material, the slow-release performance and particle size of the microspheres can be adjusted and controlled, which not only improves its drug release performance, but also improves Its environmental friendliness reduces the production cost and meets the requirements of pollution-free agricultural production.

Description

technical field [0001] The invention belongs to the technical field of pesticides, in particular to a biodegradable emamectin benzoate microsphere and a preparation method thereof. Background technique [0002] Emamectin benzoate (referred to as emamectin salt for short) is a new type of high-efficiency semi-synthetic antibiotic insecticide synthesized from the fermentation product avermectin B1. It has ultra-high efficiency, low toxicity, low residue, Pollution-free and other characteristics of biological pesticides. However, emamectin benzoate is easily degraded due to factors such as too high or too low acidity and light. In order to maintain good stability and long-lasting effect of emamectin benzoate during use and give full play to its efficacy, the easy-to-photolyze emamectin emamectin salt is made into slow-release microspheres, which can greatly delay the degradation rate and reduce the concentration in EC. , powder and other traditional dosage forms in the produc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/28A01P7/04
Inventor 徐升陈鹏浩吴祖建吴刚
Owner FUJIAN AGRI & FORESTRY UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap