Biodegradable emamectin benzoate microsphere

A technology of emamectin and benzoate, which is applied in the field of pesticides, can solve the problems of poor compatibility and complete biodegradation of materials, and achieve the goals of reducing particle size, prolonging effective control time, and improving optical stability Effect

Inactive Publication Date: 2015-09-09
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If it is blended with non-degradable polymers, the material will lose its complete biodegradability; if PLA and other aliphatic polyesters such as polycaprolactone (PCL), polydibutyl succinate (PBS) , poly 3-hydroxybutyrate (PHB) blend, although it can maintain complete biodegradability, but due to poor compatibility

Method used

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  • Biodegradable emamectin benzoate microsphere
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  • Biodegradable emamectin benzoate microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0030] (1) Preparation of drug-containing oil phase suspension: mix 0.3000g emamectin benzoate technical drug with 0.3g PLA / PPC (mass ratio 4 / 6), add 7mL dichloromethane, ice Dissolved in a water bath to obtain a drug-containing oil phase suspension; wherein, the active ingredient in the emamectin benzoate former medicine accounts for 95.8%;

[0031] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil phase suspension in step (1) into 100 mL of PVA-1788 aqueous solution under the condition of uniform dispersion of milk, wherein, PVA-1788 The content in the aqueous solution is 10 mg / ml, and the O / W primary emulsion is prepared; the emulsification conditions are: the temperature is 30°C, the dispersion speed is 7000rpm, and the emulsification time is 5min;

[0032] (3) Preparation of microspheres: Stir the primary emulsi...

Embodiment 2

[0035] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0036] (1) Preparation of drug-containing oil phase suspension: mix 0.3000g emamectin benzoate technical drug with 0.9000g PLA / PPC (mass ratio 6 / 4, add 10 mL dichloromethane, ice Dissolved in a water bath to obtain a drug-containing oil phase suspension; wherein, the active ingredient in the emamectin benzoate former medicine accounts for 95.8%;

[0037] (2) Preparation of primary emulsion: use a high-speed homogenizer to inject the drug-containing oil-phase suspension in step (1) into 100 mL of aqueous gum arabic solution under the condition of homogenous emulsion dispersion, wherein the gum arabic gum in the aqueous solution O / W primary emulsion was prepared with the content of 7.5 mg / ml in it; the emulsification conditions were: temperature 30 ℃, dispersion speed 10000 rpm, emulsification time 1.5 min;

[0038] (3) Preparation of microspheres: Pour all the primar...

Embodiment 3

[0041] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0042] (1) Preparation of drug-containing oil phase suspension: mix 0.6000g emamectin benzoate technical drug with 0.3000g PLA / PPC (mass ratio 8 / 2), add 10mL dichloromethane, ice Dissolved in a water bath to obtain a drug-containing oil phase suspension; wherein, the active ingredient in the emamectin benzoate former medicine accounts for 95.8%;

[0043] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil-phase suspension in step (1) into 100 mL of PVA-1788 aqueous solution under the condition of homogeneous emulsion dispersion, wherein, PVA-1788 The content in the aqueous solution is 10 mg / ml, and the O / W primary emulsion is prepared; the emulsification conditions are: the temperature is 30°C, the dispersion speed is 8000 rpm, and the emulsification time is 4 minutes;

[0044] (3) Preparation of microspheres: keep the...

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Abstract

The invention discloses a biodegradable emamectin benzoate microsphere and a preparation method thereof. Emamectin benzoate serves as an active substance namely a core material, and a biodegradable material serves as a balling material namely a wall material. The biodegradable emamectin benzoate microsphere has the advantages of safety, low toxicity, high efficiency, long lasting period, high stability and the like. Compared with a conventional common high-polymer wall material microsphere, the biodegradable emamectin benzoate microsphere has the advantages of high environment compatibility and good material mechanics property; meanwhile, by changing a ratio of polylactic acid to polypropylene carbonate in the wall material, the slow release performance and the particle size of the microsphere can be regulated and controlled, the drug release performance is improved, the environmental friendliness is improved, the production cost is reduced, and requirements on pollution-free agricultural production are met.

Description

technical field [0001] The invention belongs to the technical field of pesticides, in particular to a biodegradable emamectin benzoate microsphere and a preparation method thereof. Background technique [0002] Emamectin benzoate (referred to as emamectin salt for short) is a new type of high-efficiency semi-synthetic antibiotic insecticide synthesized from the fermentation product avermectin B1. It has ultra-high efficiency, low toxicity, low residue, Pollution-free and other characteristics of biological pesticides. However, emamectin benzoate is easily degraded due to factors such as too high or too low acidity and light. In order to maintain good stability and long-lasting effect of emamectin benzoate during use and give full play to its efficacy, the easy-to-photolyze emamectin emamectin salt is made into slow-release microspheres, which can greatly delay the degradation rate and reduce the concentration in EC. , powder and other traditional dosage forms in the produc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/28A01P7/04
Inventor 徐升陈鹏浩吴祖建吴刚
Owner FUJIAN AGRI & FORESTRY UNIV
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