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Magnesium alloy medical implant and preparation method thereof

A magnesium alloy and implant technology, which is applied in the field of biodegradable magnesium alloy medical implants and its preparation, can solve the problems of inappropriate degradation rate of magnesium alloy medical implants, etc.

Pending Publication Date: 2022-04-08
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The invention aims to solve the technical problems that the degradation rate of magnesium alloy medical implants is too fast and the existing surface coating method is not suitable for 3D printing complex structures

Method used

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  • Magnesium alloy medical implant and preparation method thereof
  • Magnesium alloy medical implant and preparation method thereof
  • Magnesium alloy medical implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The additive manufacturing equipment used in this example is the S-210 laser powder bed melting equipment produced by Xi’an BLT Additive Technology Co., Ltd. The magnesium alloy powder used in this example is produced by Tangshan Weihao Magnesium Powder Co., Ltd. WE43 magnesium alloy powder with a particle size range of 20-63 μm and a median diameter of 41 μm.

[0079] Before printing, draw a rectangular block with a length, width, and height of 5*2*5mm, and then use the subdivision software that comes with the laser powder bed melting printer to subdivide. After the subdivision is completed, import the layered file to the printer for preparation Print. Argon gas was used for protection during the printing process, the oxygen content in the printing chamber was controlled at 800ppm, and the temperature of the heating plate was adjusted to 200°C. The laser power used for printing is 80W, the scanning speed is 800mm / s, and the spot diameter is 70μm. The scanning track p...

Embodiment 2

[0085] In order to verify that the thermal oxidation treatment method is also effective for porous magnesium alloy implants, this example uses 3D printing to prepare a WE43 magnesium alloy porous scaffold and conduct passivation treatment, and at the same time verify its degradation behavior and mechanical properties.

[0086] The powder laser melting 3D printing equipment and WE43 magnesium alloy powder used in this embodiment are the same as those in Embodiment 1. Using 3D computer modeling software, draw a Gyroid structure porous scaffold with a diameter of 6 mm, a height of 6 mm, a porosity of 40%, and a rod diameter of 600 μm. Use the subdivision software that comes with the 3D printing device to subdivide. After the subdivision is completed, import the layered files to the printer for printing. Argon gas was used for protection during the printing process, the oxygen content in the printing chamber was controlled at 800ppm, and the temperature of the heating plate was ad...

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Abstract

The invention provides a magnesium alloy medical implant and a preparation method thereof, and the preparation method comprises the following steps: providing a magnesium alloy which comprises magnesium and at least one active element; the magnesium alloy is sequentially subjected to thermal oxidation treatment and post-treatment, the magnesium alloy medical implant is obtained, and the magnesium alloy medical implant comprises an oxide passivation layer, a middle layer and a magnesium alloy base body. The magnesium alloy medical implant has a customized appearance matched with bone defects and a composite structure comprising the oxide passivation layer on the surface, the middle layer and the magnesium alloy base body, the oxide passivation layer and the middle layer are degraded slowly in body fluid, the magnesium alloy base body is separated from the body fluid, the degradation rate of the magnesium alloy medical implant is decreased, and the service life of the magnesium alloy medical implant is prolonged. The degradation period is matched with bone tissue reconstruction and functional recovery, and the bone defect repair effect is improved. The preparation method is not influenced by geometric structures, no other materials are added, the degradation period is adjustable, the effect is stable, operability is high, and industrial production and clinical application are facilitated.

Description

technical field [0001] The invention relates to the technical field of magnesium alloy medical implants, in particular to a biodegradable magnesium alloy medical implant and a preparation method thereof. Background technique [0002] The commonly used biologically inert medical metals such as stainless steel and titanium alloy permanently occupy the bone growth space, making it difficult to achieve the overall reconstruction of the damaged bone. If a second operation is performed to remove it, it will cause new tissue trauma and economic burden to the patient. Degradable materials are attracting more and more attention. As a biodegradable metal biomaterial, magnesium alloy has many advantages: (1) The normal content of magnesium in the human body is 25g, and the density of magnesium is 1.74g / cm 3 , about 1 / 3 of the density of titanium alloy, which is similar to the density of human compact bone; (2) Young's modulus of magnesium is 45GPa, less than 1 / 2 of medical titanium all...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/04A61L27/58A61L27/56B22F10/28B22F10/64C22F1/06C23C28/00B33Y70/00
Inventor 温鹏刘金戈彭勃刘冰川田耘
Owner TSINGHUA UNIV
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