Preparation method and application of nanofibers

Abstract

The invention relates to nanofibers as well as a preparation method and an application thereof. The nanofibers are prepared from polyvinylpyrrolidone, acetone, an alkaline regulator, a surfactant andone or more of polylactic acid, polylactic acid-polyglycolic acid and poly(epsilon-caprolactone) with a gas spinning process and a compatible finishing process. The spinning process is simple, the nanofibers with smaller diameter can be obtained, furthermore, the alkaline regulator is introduced into a fiber material in the process, acidic substances produced by degradation can be regulated and controlled, the degradation speed of raw materials is reduced, and the pH value of a degradation solution is slowly increased in the later stage of degradation. According to the spinning process, the obtained fiber structure can be uniform and components can be stable with addition of the surfactant. Polyvinylpyrrolidone has good hydrophilicity, so that hydrophilicity of the nanofibers can be improved with addition of polyvinylpyrrolidone, and biocompatibility is promoted.

Description

technical field [0001] The invention belongs to the field of nanofiber materials, and particularly relates to a preparation method of polyester nanofibers and uses thereof. Background technique [0002] With the development of technology, tissue engineering materials are more and more favored by researchers. Tissue engineering materials need to have good biocompatibility, suitable mechanical properties, suitable hydrophobicity, good biodegradable absorbability, fine In the prior art, electrospinning technology is often used to prepare ultrafine fibers with fiber fineness up to nanometers, but this method still has some shortcomings, such as the solvent used is generally fluorine-containing or Chlorine, a toxic solvent, also needs to build a large electric field during spinning. [0003] In the field of tissue engineering, the commonly used electrospinning materials are synthetic polymer materials such as polylactic acid, polyglycolic acid, etc. They have good mechanical pro...

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Problems solved by technology

[0002] With the development of technology, tissue engineering materials are more and more favored by researchers. Tissue engineering materials need to have good biocompatibility, suitable mechanical properties, suitable hydrophilicity and hydrophobicity, good biodegradable absorbency, finer In the prior art, electrospinning technology is often used to prepare ultra-fine fibers with fiber fineness up to nanometer level, but this method still has some shortcomings, such as the solvent used is generally fluorine-containing or Chlorine is a toxic solvent, and it also needs to build a large electric field during spinning

[0003] In the field of tissue engineering, the commonly used electrospun materials are synthetic polymer materials such as polylactic acid and polyglycolic acid, which have good mechanical properties and biodegradability, and the degradation time in the body is too long, which may lead to poor degradation. Uniformity will cause discomfort to the human body and reduce its biocompatibility. In addition, the hydrophilicity needs to be improved. In addition, during use, these materials are prone to degradation and produce acidic substances. The accumulation of acidic substances will further promote polyester degradation. Degradation of the polymer, on the other hand, lowers the pH around the tissue, affects cell growth, and causes an inflammatory response