Controllablely degradable internal fixation composite material and preparation method and application thereof

A technology of composite materials and composite powders, which is applied in the fields of internal bone synthesis, fixers, medical science, etc., can solve the problems of affecting the mechanical properties of composite materials, the neutralization effect needs to be improved, and the burden and pain of patients will be increased, so as to achieve a good industrialization prospect , promote bone healing, improve biocompatibility

Inactive Publication Date: 2013-07-31
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, metal internal fixators made of the above-mentioned fixing materials have obvious defects: 1) The rigidity is much greater than that of cortical bone. 2) Under the action of physiological corrosion and wear, toxic metal ions and microparticles may be released, causing local tissue inflammation; 3) The material cannot be degraded, and it must be removed by a second operation after bone healing, which increases the patient's Financial and psychological burden and physical pain
But so far, the research on this type of composite materials has not been well resolved in the following aspects: 1) The uniformity of HA dispersion in the PLA matrix: both the traditional hot pressing method and the melt blending method have obvious local defects. The agglomeration phenomenon greatly affects the mechanical properties of composite materials; 2) Since HA is difficult to dissolve and absorb, its neutralization effect on the local acidic environment caused by the degradation of polylactic acid in vivo needs to be improved

Method used

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  • Controllablely degradable internal fixation composite material and preparation method and application thereof
  • Controllablely degradable internal fixation composite material and preparation method and application thereof
  • Controllablely degradable internal fixation composite material and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Prepare 500 g of Mg-HA / PLA composite material with magnesium content of 3%, HA content of 10%, and polylactic acid as the rest, and shape it into a bone screw. The steps are as follows:

[0033] 1) First, calcium nitrate (Ca(NO 3 ) 2 4H 2 O) and ammonium phosphate (NH4) 3 PO 4 ·3H 2 O is the raw material, weighed according to Ca / P=1.67 (stoichiometric ratio), and made 100 ml aqueous solution with deionized water respectively. Ca(NO 3 ) 2 The solution was all moved into a three-necked flask, and then 100 milliliters of 0.1 g / ml gelatin aqueous solution was added, the mixed solution was heated to 80° C., the reaction pH was adjusted to 9 with NaOH solution, and the (NH 4 ) 3 PO 4 solution while stirring vigorously. The reaction temperature and the pH value of the reaction system were kept constant throughout the experiment. After the dropwise addition, 100 ml of 0.1 g / ml polyethylene glycol was added and stirred at constant temperature for 30 min. Raise the te...

Embodiment 2

[0038] Prepare 500g of Mg-HA / PLA composite material with magnesium content of 2%, HA content of 8%, and polylactic acid as the rest, and shape it into a bone nail. The steps are as follows:

[0039] 1) First, calcium nitrate (Ca(NO 3 ) 2 4H 2 O) and ammonium phosphate (NH4) 3 PO 4 ·3H 2 O is the raw material, weighed according to Ca / P=1.67 (stoichiometric ratio), and made 100 ml aqueous solution with deionized water respectively. Ca(NO 3 ) 2 Move all the solution into a three-necked flask, add 100 milliliters of 0.1 g / ml gelatin aqueous solution, heat the mixed solution to 90 ° C, adjust the reaction pH value to 10 with ammonia water, and start to drop (NH 4 ) 3 PO 4 solution while stirring vigorously. The reaction temperature and the pH value of the reaction system were kept constant throughout the experiment. After the dropwise addition, 100 ml of 0.1 g / ml polyethylene glycol was added and stirred at constant temperature for 60 min. Raise the temperature of the s...

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Abstract

The invention discloses a controllable degradable internal fixation composite material, which consists of the following components in percentage by weight: 8 to 15 percent nanorod-shaped hydroxyapatite granule, 2 to 5 percent of magnesium granule and the balance of polylactic acid. The composite material is used for manufacturing bone screws, namely magnesium-nano hydroxyapatite / polylactic acid composite material is injected and molded into absorbable bone screws by an injection molding machine in the specification of 10 to 90g. The invention has the advantages that: rod-shaped n-HA granules and Mg granules are introduced into a polylactic acid matrix, wherein the rod-shaped n-HA granules can improve the toughness and bioactivity of the composite material, and the added Mg granules can neutralize the local acid environment of the degraded polylactic acid in vivo to reduce the irritation on human tissues. Meanwhile, the composite material is easy to prepare and low in cost, and has good industrial prospect.

Description

technical field [0001] The invention relates to a biodegradable internal bone fixation material and a preparation method thereof, belonging to the technical field of preparation of materials for medical surgery. Background technique [0002] Medical metal materials such as stainless steel, cobalt-based alloys, titanium alloys, etc., are currently the most widely used fracture internal fixation materials. However, metal internal fixators made of the above-mentioned fixing materials have obvious defects: 1) The rigidity is much greater than that of cortical bone. 2) Under the action of physiological corrosion and wear, toxic metal ions and microparticles may be released, causing local tissue inflammation; 3) The material cannot be degraded, and it must be removed by a second operation after bone healing, which increases the patient's Economic and psychological burden and physical pain. Therefore, in bone injury surgery, the use of in vivo degradable materials instead of trad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/12A61L31/04A61L31/02A61B17/86
Inventor 刘德宝陈民芳孙丽丽由臣
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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