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3D printing medical PLA (polylactic acid)/PCL (polycaprolactone) blend resin and preparation method thereof

A technology of polycaprolactone and three-dimensional printing, applied in the field of three-dimensional printing resin, can solve the problems of increasing difficulty in pathological analysis and difficult tissue cell engineering, and achieve good degradation rate, fast degradation rate and good tensile strength

Inactive Publication Date: 2018-11-02
MINJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the two methods of melting reaction to form graft copolymers in situ and adding low-molecular-weight compounds and reactive polymer solubilizers can greatly improve the compatibility of PLA / PCL and greatly improve the performance of the resin, they often need to The addition of a non-degradable third component to the resin increases the difficulty of pathological analysis and is difficult to apply to tissue cell engineering

Method used

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  • 3D printing medical PLA (polylactic acid)/PCL (polycaprolactone) blend resin and preparation method thereof
  • 3D printing medical PLA (polylactic acid)/PCL (polycaprolactone) blend resin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Combine L-polylactic acid (PLLA) and polyε-caprolactone (PCL) in accordance with the ratio in Table 1 with a polylactic acid / polycaprolactone diblock copolymer (PLLA-PCL) that accounts for 5% of the total mass of the two The solubilizer is mixed uniformly and pelletized in the extruder. The obtained pellets are then made into a linear material by a three-dimensional printing consumable extruder to obtain a three-dimensional printing medical PLLA / PCL blend resin.

[0018] Then the resin is printed into mechanical performance test and molding shrinkage test specimens using FDM technology for related tests. The results of the study indicate that the toughness of the resin is greatly improved, the hardness is reduced, and the biodegradation rate is slowed down, which is more conducive to the preparation of medical intervention materials such as vascular stents.

[0019] Table 1 Performance of PLLA / PCL resin when using diblock copolymer (PLLA-PCL) as a solubilizer

[0020]

Embodiment 2

[0022] The L-polylactic acid (PLLA) and polyε-caprolactone (PCL) were combined with the polylactic acid / polycaprolactone triblock copolymer (PLLA-PCL-PCL- PLLA) The solubilizer is uniformly mixed and pelletized in an extruder; the obtained pellets are then made into a linear material by a three-dimensional printing consumable extruder to obtain a three-dimensional printing medical PLA / PCL blend resin.

[0023] Then the resin is printed into mechanical performance test and molding shrinkage test specimens using FDM technology for related tests. The results of the study indicate that the toughness of the resin is greatly improved, the hardness is reduced, and the biodegradation rate is slowed.

[0024] Table 2 Performance of PLLA / PCL resin when using diblock copolymer (PLLA-PCL) as a solubilizer

[0025]

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Abstract

The invention relates to 3D printing medical PLA (polylactic acid) / PCL (polycaprolactone) blend resin and a preparation method thereof. The preparation method comprises steps as follows: PLA and PCL are mixed in the mass ratio being (100:5)-(5:100), a PLA / PCL copolymer solubilizer accounting for 5% of the total mass of PLA and PCL is added, and the mixture is mixed uniformly and granulated in an extruder; granules are prepared into linear materials through a 3D printing consumable extruder, and the 3D printing medical PLA / PCL blend resin is obtained. The 3D printing medical PLA / PCL blend resincan be further printed into a high-precision medical intervention material through a fused deposition molding 3D printing technology. The 3D printing medical PLA / PCL blend resin has whole-resin biodegradability, control of mechanical performance, biocompatibility, biodegradability and drug coating property of medical resin is realized by changing the proportion of PLA and PCL, and individualizedand accurate medical treatment is really realized.

Description

Technical field [0001] The invention belongs to the field of three-dimensional printing resins, and specifically relates to a three-dimensional printing medical polylactic acid / polycaprolactone blend resin and a preparation method thereof. Background technique [0002] Thanks to the excellent biocompatibility and biodegradability of medical materials such as PLA and PCL, three-dimensional printing medical devices have received widespread attention in the industry, but doubts have also followed. A small number of patients have slow degradation of PLA in the body, resulting in foreign body reactions and delayed aseptic inflammatory reactions, but generally only mild inflammatory reactions in the initial stage of implantation, no inflammatory infiltration, and no effect on the growth and repair of surrounding tissues interference. In addition, the natural defects in the properties of PLA and PCL materials also make their shortcomings prominent in application. For example, PLA-base...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04
CPCC08L67/04C08L2201/06C08L2205/025C08L2205/03
Inventor 薛涵与方润李心忠林棋
Owner MINJIANG UNIV
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