3D printed digital artificial bone and preparation method thereof

A 3D printing and artificial bone technology, applied in additive processing, medical science, prosthesis, etc., can solve the problems of unsatisfactory curative effect, inconvenient repair and treatment of patients with bone defects, etc., and achieve stable, uniform and perfect matching of size and shape , the effect of stable absorption speed

Active Publication Date: 2015-11-11
上海浦卫生物科技有限公司
View PDF4 Cites 25 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the fact that the artificial bone prepared by the existing technology and materials is difficult to match the natural bone, it brings a lot of inconvenience to the repair treatment of patients with bone defects, and the curative effect is difficult to be satisfactory.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The cortical bone material is PLA with a molecular weight of 300,000; the cancellous bone material is a mixture of PLA with a molecular weight of 90,000 and HA with a particle size of 20 nm, and the ratio of the two is 2:2.

[0020] The specific 3D printing process is:

[0021] According to the patient's CT, magnetic resonance imaging (MRI) and other images and data, obtain the 3D data of the patient's bone defect, use Simpleware3.1 software to construct its specific CAD solid model, and convert it into an STL format file through the numerical control conversion of the forming machine , and then use MedCAD software to cut out a series of slices with a thickness of 0.2mm, and then transfer each piece of data to the rapid automatic prototyping machine.

[0022] The material box of the rapid automatic molding machine contains PLA with a molecular weight of 300,000, and a mixture of PLA and HA with a molecular weight of 90,000.

[0023] Applying the principle of "layered s...

Embodiment 2

[0028] The cortical bone material is PLA with a molecular weight of 300,000; the cancellous bone material is a mixture of PLA with a molecular weight of 90,000 and HA with a particle size of 30 nm, and the ratio of the two is 3:2.

[0029] The specific 3D printing process is:

[0030]According to the patient's CT, magnetic resonance imaging (MRI) and other imaging data, the 3D data of the patient's bone defect is obtained, and the Simpleware3.1 software is used to construct its specific CAD solid model, which is converted into an STL format file through the numerical control conversion of the forming machine. Then use MedCAD software to cut out a series of slices with a thickness of 0.2mm, and then transfer the data of each slice above to the rapid automatic prototyping machine.

[0031] The material box of the rapid automatic molding machine contains PLA with a molecular weight of 300,000, and a mixture of PLA and HA with a molecular weight of 90,000.

[0032] Applying the p...

Embodiment 3

[0037] The cortical bone material is PLA with a molecular weight of 300,000; the cancellous bone material is a mixture of PLA with a molecular weight of 90,000 and HA with a particle size of 50 nm, and the ratio of the two is 2:3.

[0038] The specific 3D printing process is:

[0039] According to the patient's CT, magnetic resonance imaging (MRI) and other imaging data, the 3D data of the patient's bone defect is obtained, and the Simpleware3.1 software is used to construct its specific CAD solid model, which is converted into an STL format file through the numerical control conversion of the forming machine. Then use MedCAD software to cut out a series of slices with a thickness of 0.2mm, and then transfer the data of each slice above to the rapid automatic prototyping machine.

[0040] The material box of the rapid automatic molding machine contains PLA with a molecular weight of 300,000, and a mixture of PLA and HA with a molecular weight of 90,000.

[0041] Applying the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
Login to view more

Abstract

The invention discloses a 3D printed digital artificial bone. The artificial bone consists of a cortical bone, a cancellous bone and a marrow cavity, wherein the cortical bone is composed of poly-L-lactic acid or polyester-ester-ketone; the cancellous bone is formed by mixing poly-L-lactic acid and hydroxyapatite; the molecular weight of the poly-L-lactic acid of which the cortical bone is composed higher than that of which the cancellous bone composed; the cortical bone and the cancellous bone are simultaneously prepared by a 3D printing technology. The invention also discloses a 3D printing method for the digital artificial bone. According to the artificial bone disclosed by the invention, in micrometer and millimeter scales, the porosity of the cortical bone is 10 percent; the porosity of the cancellous bone is 60-80 percent, and the pore size of the cancellous bone is 120-220 micrometers. The 3D printed digital artificial bone has the porosity, the pore size and the mechanical property as those of a bone structure of human beings.

Description

technical field [0001] The invention relates to a 3D printed digital artificial bone and a preparation method thereof. Background technique [0002] The repair and reconstruction of traumatic or tumor bone defects has always been one of the difficult problems in orthopedics. Clinically, autologous bone transplantation is currently the most effective treatment method, but there are disadvantages such as limited materials, prolonged operation time, and secondary trauma to patients. Finding a safe and effective alternative to autologous bone grafting has always been a research hotspot in international orthopedics. [0003] Bone has a complex spatial structure, which is composed of cortical bone, cancellous bone, and bone marrow cavity from outside to inside, and its hierarchical structure includes nanoscale, microscale, millimeter, and centimeter levels. Bone is mineralized collagen fibers at the nanoscale, including collagen microfibrils and hydroxyapatite. Collagen microfi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/58A61L27/50B29C67/00B33Y10/00
Inventor 胡堃李路海余均武危岩杜彩霞
Owner 上海浦卫生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap