Modification method used for surface of magnesium alloy stent

Abstract

The invention discloses a modification method used for the surface of a magnesium alloy stent and contains controlledly degradable magnesium alloy stent surface micro-arc oxidation modification treatment and drug molecule biomimetic deposition; the magnesium alloy stent surface micro-arc oxidation modification treatment is first performed on the surface of magnesium alloy stent substrate to form controlledly degradable microporous ceramic oxide film with high porosity, the thickness of the film is 80-120mu m, the porosity is 20-40%; then drug molecule biomimetic deposition capable of promoting endothelial growth or dissolving thrombus and anticoagulating is performed on the microporous ceramic oxide film and the width of the settled layer is 5-10mu m. The modification of the surface of the magnesium alloy stent of the invention can effectively improve the in vivo biodegradation rate of the stent and the corresponding consistency of the mechanical property thereof, increase the compatibility between the stent and vascular walls, reduce the restenosis rate of blood vessels, lower the incidence of complications of patients and improve the survival rate and the life quality.

Description

technical field

[0001] The invention relates to alloy surface modification, in particular to the surface modification of a magnesium alloy vascular stent, and belongs to the technical field of medical devices. Background technique

[0002] According to the "Global Burden of Disease 2004" released by the World Health Organization, cardiovascular disease is the main cause of death in the world. In 2004, about 7.2 million patients died of ischemic heart disease worldwide, accounting for 12.2% of the total mortality rate. It ranks first among the 20 common mortality diseases. In the "2008 China Health Statistical Yearbook", the Ministry of Health of China analyzed the main disease mortality rate of Chinese urban residents in 2007 and showed that the mortality rate of heart disease was 16.29%, ranking third only after malignant tumors and cerebrovascular diseases. Cardiovascular disease mortality and disability mainly include ischemic heart disease and coronary embolism; cardiov...

Examples

Embodiment 1

[0024] Using metal magnesium with a mass purity of 99.99% (the remaining 0.01% is metal aluminum) is engraved with an inert gas protection laser to make a mesh tubular stent sample, with an average mesh diameter of 0.1±0.02mm, and ultrasonic cleaning in acetone and alcohol for 10 minutes ;

[0025]After the bracket is taken out and dried, the output power of the high-frequency switching power supply is 400W, and the power density is 160W / cm 2 , under the condition of switching frequency 200kHz, the calcium salt electrolyte (0.28mol / L NH 4 h 2 PO 4 , 0.082mol / LCa(CH 3 COO) 2 ·H 2 O) and phosphate electrolyte (15g / L Na 5 P 3 o 10 , 1.6g / L NaOH, 1g / LNa 2 WO 4 , 1.85g / L disodium edetate dihydrate (Na 2 -EDTA)) were subjected to micro-arc oxidation treatment for 20 minutes and 15 minutes respectively, so that the surface of the support obtained a microporous ceramic oxide film layer with a porosity of 75 μm and a porosity of 40%;

[0026] Prepare Ca(NO 3 ) 2 and (NH ...

Embodiment 2

[0032] Use AZ31 magnesium alloy to make a stent sample, with an average wire diameter of 0.1±0.02mm, and ultrasonically clean it in acetone and alcohol for 12 minutes respectively;

[0033] After the bracket is taken out and dried, the output power of the high-frequency switching power supply is 380W, and the power density is 200W / cm 2 , under the condition of switching frequency 180kHz, the calcium salt electrolyte (0.085mol / L NH 4 h 2 PO 4 , 0.106mol / LCa(CH 3 COO) 2 ·H 2 O) and 55°C phosphate electrolyte (15.3g / LNa 5 P 3 o 10 , 1.5g / LNaOH, 0.8g / LNa 2 WO 4 , 1.7g / L disodium edetate dihydrate (Na 2 -EDTA)) were subjected to micro-arc oxidation treatment for 25 minutes and 18 minutes respectively, so that the surface of the stent obtained a microporous ceramic oxide film layer with a porosity of 100 μm and a porosity of 30%;

[0034] Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 In the mixed solution, the anticancer drug polylactic acid and the anticoagulant low molec...

Embodiment 3

[0040] Use AZ91 magnesium alloy to make stent samples (average wire diameter 0.1±0.02mm), and ultrasonically clean them in acetone and alcohol for 10 minutes;

[0041] After the bracket is taken out and dried, the output power of the high-frequency switching power supply is 350W, and the power density is 180W / cm 2 , under the condition of switching frequency 250kHz, the calcium salt electrolyte (0.217mol / L NH 4 h 2 PO 4 , 0.15mol / LCa(CH 3 COO) 2 ·H 2 O) and phosphate electrolyte (16g / L Na 5 P 3 o 10 , 2g / L NaOH, 0.5g / LNa 2 WO 4 , 1.9g / L disodium edetate dihydrate (Na 2 -EDTA)) were subjected to micro-arc oxidation treatment for 30 minutes and 20 minutes respectively, so that the surface of the stent obtained a microporous ceramic oxide film layer with a porosity of 110 μm and a porosity of 20%;

[0042] Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 mixed solution, and paclitaxel was dissolved in the solution so that its mass concentration was prepared to be 3%, and t...

technical field

[0001] The invention relates to alloy surface modification, in particular to the surface modification of a magnesium alloy vascular stent, and belongs to the technical field of medical devices. Background technique

[0002] According to the "Global Burden of Disease 2004" released by the World Health Organization, cardiovascular disease is the main cause of death in the world. In 2004, about 7.2 million patients died of ischemic heart disease worldwide, accounting for 12.2% of the total mortality rate. It ranks first among the 20 common mortality diseases. In the "2008 China Health Statistical Yearbook", the Ministry of Health of China analyzed the main disease mortality rate of Chinese urban residents in 2007 and showed that the mortality rate of heart disease was 16.29%, ranking third only after malignant tumors and cerebrovascular diseases. Cardiovascular disease mortality and disability mainly include ischemic heart disease and coronary embolism; cardiov...

Examples

Embodiment 1

[0024] Using metal magnesium with a mass purity of 99.99% (the remaining 0.01% is metal aluminum) is engraved with an inert gas protection laser to make a mesh tubular stent sample, with an average mesh diameter of 0.1±0.02mm, and ultrasonic cleaning in acetone and alcohol for 10 minutes ;

[0025]After the bracket is taken out and dried, the output power of the high-frequency switching power supply is 400W, and the power density is 160W / cm 2 , under the condition of switching frequency 200kHz, the calcium salt electrolyte (0.28mol / L NH 4 h 2 PO 4 , 0.082mol / LCa(CH 3 COO) 2 ·H 2 O) and phosphate electrolyte (15g / L Na 5 P 3 o 10 , 1.6g / L NaOH, 1g / LNa 2 WO 4 , 1.85g / L disodium edetate dihydrate (Na 2 -EDTA)) were subjected to micro-arc oxidation treatment for 20 minutes and 15 minutes respectively, so that the surface of the support obtained a microporous ceramic oxide film layer with a porosity of 75 μm and a porosity of 40%;

[0026] Prepare Ca(NO 3 ) 2 and (NH ...

Embodiment 2

[0032] Use AZ31 magnesium alloy to make a stent sample, with an average wire diameter of 0.1±0.02mm, and ultrasonically clean it in acetone and alcohol for 12 minutes respectively;

[0033] After the bracket is taken out and dried, the output power of the high-frequency switching power supply is 380W, and the power density is 200W / cm 2 , under the condition of switching frequency 180kHz, the calcium salt electrolyte (0.085mol / L NH 4 h 2 PO 4 , 0.106mol / LCa(CH 3 COO) 2 ·H 2 O) and 55°C phosphate electrolyte (15.3g / LNa 5 P 3 o 10 , 1.5g / LNaOH, 0.8g / LNa 2 WO 4 , 1.7g / L disodium edetate dihydrate (Na 2 -EDTA)) were subjected to micro-arc oxidation treatment for 25 minutes and 18 minutes respectively, so that the surface of the stent obtained a microporous ceramic oxide film layer with a porosity of 100 μm and a porosity of 30%;

[0034] Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 In the mixed solution, the anticancer drug polylactic acid and the anticoagulant low molec...

Embodiment 3

[0040] Use AZ91 magnesium alloy to make stent samples (average wire diameter 0.1±0.02mm), and ultrasonically clean them in acetone and alcohol for 10 minutes;

[0041] After the bracket is taken out and dried, the output power of the high-frequency switching power supply is 350W, and the power density is 180W / cm 2 , under the condition of switching frequency 250kHz, the calcium salt electrolyte (0.217mol / L NH 4 h 2 PO 4 , 0.15mol / LCa(CH 3 COO) 2 ·H 2 O) and phosphate electrolyte (16g / L Na 5 P 3 o 10 , 2g / L NaOH, 0.5g / LNa 2 WO 4 , 1.9g / L disodium edetate dihydrate (Na 2 -EDTA)) were subjected to micro-arc oxidation treatment for 30 minutes and 20 minutes respectively, so that the surface of the stent obtained a microporous ceramic oxide film layer with a porosity of 110 μm and a porosity of 20%;

[0042] Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 mixed solution, and paclitaxel was dissolved in the solution so that its mass concentration was prepared to be 3%, and t...