Biodegradable polyester material and preparation method and application thereof, carrier material and preparation method thereof

A technology of biodegradable polyester and carrier materials, applied in pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of insufficient mechanical properties, fast degradation rate, poor heat resistance, etc.

Active Publication Date: 2020-08-18
BEIJING CO FOUND HIGH TECH INCUBATOR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has defects such as fast degradation rate, poor heat resistance, and insufficient mechanical properties, which limit its application in long-acting drug carriers.

Method used

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  • Biodegradable polyester material and preparation method and application thereof, carrier material and preparation method thereof
  • Biodegradable polyester material and preparation method and application thereof, carrier material and preparation method thereof
  • Biodegradable polyester material and preparation method and application thereof, carrier material and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0042] The invention provides a kind of preparation method of biodegradable polyester material, comprises the following steps:

[0043] Mix 1,4-butanediol, dimethyl terephthalate, polycaprolactone, and a transesterification catalyst to perform a transesterification reaction to obtain a transesterification product system;

[0044] The transesterification product system, chain extender, polycondensation antioxidant and polycondensation catalyst are mixed for polycondensation reaction to obtain biodegradable polyester material.

[0045] In the present invention, unless otherwise specified, the required preparation materials are commercially available products well known to those skilled in the art.

[0046]The invention mixes 1,4-butanediol, dimethyl terephthalate (DMT), polycaprolactone and a transesterification catalyst to carry out a transesterification reaction to obtain a transesterification product system. In the present invention, the molar ratio of the 1,4-butanediol, di...

Embodiment 1

[0079] The preparation process of tetrabutyl titanate-magnesium acetate-metal organic compound compound is as follows: mix 100g tetrabutyl titanate with 150mL methanol, obtain a saturated solution, reflux for 24h, evaporate half of the methanol, and convert the obtained organic titanium Product 175g is mixed with titanium powder (KRTi-4) according to mass ratio 1:1, obtains titanium catalyst; Said titanium catalyst 10g, magnesium oxide powder 15g and stannous octoate 22g are mixed, and gained mixture is mixed with ethyl acetate again according to mass Mix well at a ratio of 1:1, heat to boiling, reflux for 1 hour, add to the reaction kettle while it is hot, and carry out compounding at 85°C for 120 minutes to obtain a liquid compound, namely tetrabutyl titanate-magnesium acetate-metal organic compound compound. In this example, the mass percentage of each effective component in the tetrabutyl titanate-magnesium acetate-metal organic compound composite is calculated based on the...

Embodiment 2

[0083] The preparation process of tetrabutyl titanate-magnesium acetate-metal organic compound compound is as follows: mix 100g tetrabutyl titanate with 150mL methanol, obtain a saturated solution, reflux for 24h, evaporate half of the methanol, and convert the obtained organic titanium Product 175g is mixed with titanium powder (KRTi-4) according to mass ratio 1:1, obtains titanium catalyst; Said titanium catalyst 10g, magnesium oxide powder 7.5g and tetraphenyltin 8.1g are mixed, and gained mixture is mixed with ethyl acetate The esters are fully fused according to the mass ratio of 1:1, heated to boiling, refluxed for 1 hour, added to the reactor while hot, and compounded at 85°C for 120 minutes to obtain a liquid compound, namely tetrabutyl titanate-magnesium acetate-metal organic compound Complex. In this example, the mass percentage of each effective component in the tetrabutyl titanate-magnesium acetate-metal organic compound composite is calculated based on the mass pe...

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Abstract

The invention provides a biodegradable polyester material and a preparation method and application thereof, a carrier material and a preparation method thereof, and belongs to the technical field of carrier materials. According to the invention, dimethyl terephthalate and polycaprolactone are used as monomers to synthesize the polyester material; the prepared polyester material contains polycaprolactone and a rigid aromatic ring structure of a polyester structure, the aromatic ring structure can improve the overall strength, impact performance, heat resistance and the like of the material, andthe open-loop polycaprolactone chain structure in the transesterification process is good in flexibility and can be completely degraded under natural conditions; furthermore, the prepared polyester material integrates the performance advantages of two reaction monomers (dimethyl terephthalate and polycaprolactone); the elongation at break of the polyester material is obviously improved, the heatresistance is obviously improved, and meanwhile, the polyester material has certain corrosion resistance and a shape memory function, is low in degradation rate and has a wide application prospect inthe aspect of long-acting drug carriers.

Description

technical field [0001] The invention relates to the technical field of carrier materials, in particular to a biodegradable polyester material, a preparation method and application thereof, a carrier material and a preparation method thereof. Background technique [0002] A drug carrier refers to a system that can change the way a drug enters the human body and its distribution in the body, controls the release rate of the drug, and delivers the drug to the target organ. Drug carrier materials play a very important role in the research of controlled-release preparations. Since the 1960s, research on drug-controlled release systems has attracted widespread attention. The drug controlled release system can improve the utilization rate, safety and effectiveness of the drug, thereby reducing the frequency of administration, so it has attracted attention. [0003] Drug carrier research is of great significance in the research of new drug release methods, and it is also an importa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/60C08G63/78C08G63/66A61K47/34
CPCC08G63/60C08G63/78C08G63/66A61K47/34
Inventor 钱志国尹继磊孙玉增付琪轩曹亮赵梓杉钱毅朱朗晖刘天骄孙洁竺朝山毕立王利新宋佳唐鸣
Owner BEIJING CO FOUND HIGH TECH INCUBATOR
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