Soft tissue repair patch material, soft tissue repair patch and manufacturing method and application of soft tissue repair patch

A production method and soft tissue technology, applied in tissue regeneration, additive processing, prosthesis, etc., can solve the problems of low cell biological activity, insufficient mechanical properties, fast degradation time, etc., and achieve good cell activity and good biocompatibility. , the effect of sufficient mechanical properties

Active Publication Date: 2021-11-19
NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing soft tissue repair patches all have technical problems of insufficient mechanical properties, fast degradation time or low cell biological activity to varying degrees.

Method used

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  • Soft tissue repair patch material, soft tissue repair patch and manufacturing method and application of soft tissue repair patch
  • Soft tissue repair patch material, soft tissue repair patch and manufacturing method and application of soft tissue repair patch
  • Soft tissue repair patch material, soft tissue repair patch and manufacturing method and application of soft tissue repair patch

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Experimental program
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Embodiment approach

[0069] As an optional embodiment of the present invention, the sodium alginate / graphene hydrogel includes the following components: sodium alginate, gelatin, graphene and a first solvent;

[0070] Wherein, the mass ratio of sodium alginate, gelatin, graphene and the first solvent is (10-30): (10-30): (0.01-0.3): 1000, preferably (11-28): (11-28 ): (0.1-0.3): 1000; typical but non-limiting mass ratios of sodium alginate, gelatin, graphene and first solvent are 10:10:0.01:1000, 11:11:0.1:1000, 20:10 :0.01:1000, 30:10:0.01:1000, 10:20:0.01:1000, 10:30:0.01:1000, 20:20:0.01:1000, 20:20:0.02:1000, 20:20:0.2 :1000, 20:20:0.3:1000, 20:30:0.01:1000, 30:20:0.01:1000, 28:28:0.3:1000, 30:30:0.01:1000, 10:10:0.1:1000 , 10:10:0.2:1000, 10:10:0.3:1000, 20:10:0.1:1000, 30:10:0.2:1000, 10:20:0.1:1000, or 30:20:0.3:1000.

[0071] The "comprising" in the present invention means that besides the above-mentioned components, other components may also be included, and these other components endow...

Embodiment 1

[0126] This embodiment provides a soft tissue repair patch material, including sodium alginate / graphene hydrogel and fibrin / graphene hydrogel independently, sodium alginate / graphene hydrogel and fibrin / graphene The mass ratio of hydrogel is 3:1.

[0127] Wherein, the sodium alginate / graphene hydrogel includes the following components: sodium alginate, gelatin, graphene and PBS, and the mass ratio of sodium alginate, gelatin, graphene and PBS is 20:20:0.02:1000.

[0128] The preparation method of sodium alginate / graphene hydrogel comprises the following steps:

[0129]Weigh 100 mg of gelatin and sterilize it by irradiation for later use. Weigh 100 mg of sodium alginate and dissolve it in PBS, stir and dissolve at room temperature for 2 hours at a speed of 300 rpm, and filter and sterilize it with a sterile filter. Sterilized gelatin was added to sodium alginate after filter sterilization, and shaken at 37°C for 2 hours to dissolve and mix well to obtain gel A;

[0130] Graphe...

Embodiment 2

[0136] This embodiment provides a patch material for soft tissue repair, except that the mass ratio of sodium alginate, gelatin, graphene and PBS in the sodium alginate / graphene hydrogel is 20:20:0.1:1000, the remaining steps are the same as in the embodiment 1 is the same.

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Abstract

The invention provides a soft tissue repair patch material, a soft tissue repair patch and a manufacturing method and application of the soft tissue repair patch, and relates to the technical field of biological tissue repair. The soft tissue repair patch material comprises sodium alginate / graphene hydrogel and fibrous protein / graphene hydrogel, wherein the sodium alginate / graphene hydrogel has certain mechanical strength and is low in degradation rate, and the defects that the mechanical property of the fibrous protein / graphene hydrogel is insufficient and the degradation rate is too high can be overcome; therefore, enough mechanical support and tissue repair time are provided for a prepared soft tissue repair patch, the fibrous protein / graphene hydrogel is beneficial to mass amplification and propagation of cells, soft tissue repair is promoted, and through cooperative use of the two hydrogel systems, the soft tissue repair patch prepared from the soft tissue repair patch material is endowed with mechanical properties suitable for clinical use, a degradation rate matched with tissue repair and good cell compatibility, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of biological tissue repair, and in particular relates to a soft tissue repair patch material, a soft tissue repair patch and a production method and application thereof. Background technique [0002] The soft tissue repair patch is mainly used to fill the missing tissue in the damaged part after it is implanted into the organism, and under the induction of the material, the human body's own repair function can gradually grow new tissue in the original position, replacing the biological material , to complete the process of organ tissue regeneration. Treatment with soft tissue repair patches is a promising therapeutic approach in the field of biological tissue repair. However, the existing soft tissue repair patches all have technical problems of insufficient mechanical properties, fast degradation time or low biological activity of cells to varying degrees. [0003] In view of this, the present invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/08A61L27/20A61L27/22A61L27/38A61L27/50A61L27/52A61L27/58A61F2/00B33Y80/00
CPCA61L27/20A61L27/225A61L27/222A61L27/08A61L27/3813A61L27/3826A61L27/52A61L27/58A61L27/50A61F2/0063B33Y80/00A61L2430/34A61F2210/0004A61F2210/00A61F2240/001C08L5/04C08L5/08
Inventor 张楷乐牛长梅杨熙李文尧傅强赵伟新王丽阳
Owner NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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