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Biodegradable iron-zinc-magnesium-based gradient composites based on biological bone healing and its preparation

A composite material and bone healing technology, applied in the fields of medical science, chemical instruments and methods, layered products, etc., can solve the problem of not being able to adapt to the constant changes in mechanical properties, reducing the corrosion rate of magnesium-based materials, and unable to independently meet the requirements of biological bone healing. and other problems, to achieve the effect of convenient and fast adjustment, dense and reliable combination

Inactive Publication Date: 2015-11-18
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, reducing the corrosion rate of magnesium-based materials by studying new magnesium alloys cannot adapt to the changing requirements of mechanical properties in the process of biological bone healing.
That is to say, in view of the fact that a single degradable metal or alloy has its own performance characteristics, since a single metal or alloy cannot achieve variable stiffness and corrosion rate, it cannot independently meet the conceptual requirements of biological bone healing

Method used

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  • Biodegradable iron-zinc-magnesium-based gradient composites based on biological bone healing and its preparation
  • Biodegradable iron-zinc-magnesium-based gradient composites based on biological bone healing and its preparation
  • Biodegradable iron-zinc-magnesium-based gradient composites based on biological bone healing and its preparation

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Effect test

Embodiment 1

[0033] The rat model is used, and the thickness of each gradient layer of the material is designed according to the bone healing process of the rat. At the initial stage of implantation, materials with high elastic modulus and relatively slow degradation are required to ensure strong fixation, which is conducive to the growth of bone tissue. After 5 weeks, if the fixation is strong again, problems such as bone resorption caused by stress shielding effect will occur, which will affect bone tissue. heal. Therefore, after 5 weeks of rigid fixation, 3 weeks of elastic fixation is required, and a material with a lower elastic modulus is required at this time. After 8 weeks, the bone tissue is generally repaired, and the implant material needs to be rapidly degraded. Starting from the mechanical performance requirements of biological bone healing, combined with the respective advantages of iron, zinc and magnesium materials, a new type of degradable iron-zinc-magnesium-based gradie...

Embodiment 2

[0045] Taking the femur fracture in a 10-year-old child as an example, the thickness of each gradient layer of the material is designed according to the bone healing process of the child. At the initial stage of implantation, materials with high elastic modulus and relatively slow degradation are required to ensure strong fixation, which is conducive to the growth of bone tissue. After 3 weeks, if the fixation is strong again, problems such as bone resorption caused by stress shielding effect will occur, which will affect bone tissue. heal. Therefore, after 7 weeks of strong fixation, 3 weeks of elastic fixation is required, and a material with a lower elastic modulus is required at this time. After 7 weeks, the bone tissue is generally repaired, and the implant material needs to be rapidly degraded. Starting from the mechanical performance requirements of biological bone healing, combined with the respective advantages of iron, zinc, and magnesium materials, a new type of de...

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Abstract

The invention discloses a degradable iron, zinc and magnesium-based gradient composite material based on biological bone healing. A zinc layer and an iron layer are sequentially arranged on the surface of a magnesium matrix, and the thickness or the diameter of the magnesium matrix is 30-90% of bone dimension in the repaired part. The thicknesses of the zinc and iron layers are respectively determined according to the corrosion rates of zinc and iron in an in vitro simulated body fluid. According to the composite material, rigid fixation in early stage is realized to promote bone healing, the composite material is gradually degraded, use of the material with lower rigidity is transited to dynamic fixation, and finally, the material is fully absorbed in vivo to prevent from being taken out in the second operation. Rapid degradation in the non-mechanical bearing later stage is realized, and growth by differentiation of bone cells and ingrowth of blood vessels on the surface of material are induced by hoping to combine the advantages that iron in higher rigidity in the early stage realizes rigid fixation and zinc in lower rigidity in the middle stage realizes dynamic fixation by means of quicker corrosion rate of magnesium. Finally, the composite material is fully absorbed, so as to realize the bone repairing purpose. The composite material disclosed by the invention is applicable to gradient structure designs of internal fixing materials after fracture with change demands on mechanical property with the passage of time.

Description

technical field [0001] The invention belongs to a preparation method of a composite material, in particular to a medical composite material meeting the clinical requirements of biological bone healing. Background technique [0002] As the largest tissue and organ in the human body, bone bears important responsibilities for life activities, but it is the most likely to cause defects. Millions of patients with bone tissue defects need surgical treatment. In China, a country with a large population, it is estimated that more than 3 million patients with bone defects or dysfunction are caused by traumatic fractures, spinal degenerative diseases, bone tumors, bone tuberculosis and other orthopedic diseases caused by traffic accidents and production safety accidents every year. On the rise, the potential market demand is huge. Carrying out research on new and practical bone repair materials is of great significance to improving the life expectancy and quality of life of the peopl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B32B15/01B32B15/18C25D3/22C25D3/20A61L27/40A61L27/04
Inventor 魏强李小月张善勇马剑雄
Owner TIANJIN UNIV
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