Fully absorbed mg-zn-ag system amorphous medical implant substrate, its preparation method and application

A fully absorbed, amorphous technology, applied in medical science, prosthesis, surgery, etc., can solve the problems of inability to form protective oxide film, fast degradation rate of magnesium and magnesium alloys, loss of function of implanted components, etc. Market application prospect, excellent mechanical strength and hardness, slow degradation effect

Active Publication Date: 2021-07-13
PEKING UNIV SHENZHEN GRADUATE SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1) The standard electrode potential of magnesium is very low, it is easy to corrode, and cannot form an effective protective oxide film, especially the Cl in body fluids - It will accelerate the corrosion of magnesium alloys, causing the degradation rate of magnesium and magnesium alloys in the human body to be too fast, which will easily lead to premature loss of function of its implanted components before the injured tissue heals;

Method used

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  • Fully absorbed mg-zn-ag system amorphous medical implant substrate, its preparation method and application
  • Fully absorbed mg-zn-ag system amorphous medical implant substrate, its preparation method and application
  • Fully absorbed mg-zn-ag system amorphous medical implant substrate, its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0043] (1) According to the designed alloy composition ratio, weigh 76at.%Mg, 20at.%Zn and 4at.%Ag on an electronic balance with an accuracy of 0.0001g;

[0044] (2) put the weighed Mg, Zn, Ag raw materials into the test tube of the amorphous smelting furnace, carry out mixed smelting in the presence of high-purity inert protective gas helium, and the high-purity inert protective gas pressure is 1 standard atmospheric pressure , the input voltage of the amorphous melting furnace is three-phase 380V 50-60Hz, the maximum power is 40kW, and the working current is 300-1800A;

[0045] (3) remelting the obtained alloy at least 3 times, then feeding high-pressure inert protective gas helium into the test tube of the amorphous smelting furnace to carry out metal spray casting, and the high-pressure inert protective gas pressure is about 10Mpa;

[0046](4) demoulding after spray casting to obtain the fully absorbed Mg-Zn-Ag amorphous alloy sample A1 of the present invention: Mg76Zn20Ag...

Embodiment 2

[0049] (1) According to the designed alloy composition ratio, weigh 73at.%Mg, 23at.%Zn and 4at.%Ag on an electronic balance with an accuracy of 0.0001g;

[0050] (2) put the weighed Mg, Zn, Ag raw materials into the test tube of the amorphous smelting furnace, and carry out mixed smelting in the presence of high-purity inert protective gas argon, and the high-purity inert protective gas pressure is 1 standard atmospheric pressure , the input voltage of the amorphous melting furnace is three-phase 380V 50-60Hz, the maximum power is 40kW, and the working current is 300-1800A;

[0051] (3) remelting the obtained alloy at least 3 times, then feeding high-pressure inert protective gas argon into the test tube of the amorphous smelting furnace to carry out metal spray casting, and the high-pressure inert protective gas pressure is about 10Mpa;

[0052] (4) demoulding after spray casting to obtain the fully absorbed Mg-Zn-Ag amorphous alloy sample A2 of the present invention: Mg73Zn2...

Embodiment 3

[0055] (1) According to the designed alloy composition ratio, weigh 70at.%Mg, 26at.%Zn and 4at.%Ag on an electronic balance with an accuracy of 0.0001g;

[0056] (2) put the weighed Mg, Zn, Ag raw materials into the test tube of the amorphous smelting furnace, carry out mixed smelting in the presence of high-purity inert protective gas helium, and the high-purity inert protective gas pressure is 1 standard atmospheric pressure , the input voltage of the amorphous melting furnace is three-phase 380V 50-60Hz, the maximum power is 40kW, and the working current is 300-1800A;

[0057] (3) remelting the obtained alloy at least 3 times, then feeding high-pressure inert protective gas helium into the test tube of the amorphous smelting furnace to carry out metal spray casting, and the high-pressure inert protective gas pressure is about 10Mpa;

[0058] (4) demoulding after spray casting to obtain the fully absorbed Mg-Zn-Ag amorphous alloy sample A3 of the present invention: Mg73Zn23A...

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Abstract

The invention relates to a fully absorbed Mg-Zn-Ag based amorphous medical implant base material with strong corrosion resistance, high strength and good biocompatibility, and also provides its preparation method and application. The fully absorbed Mg The -Zn-Ag based amorphous medical implant substrate is made of a Mg-Zn-Ag amorphous alloy having the following composition consisting of the following composition in the following atomic percentages Composition: silver 0%-10%, and the silver content is not 0%, zinc 15%-40%, impurity 0%-5%, and the balance is magnesium. The fully absorbed Mg-Zn-Ag based amorphous medical implant substrate of the present invention has excellent mechanical strength and hardness, low gas release during use, and slow degradation rate in the human body, and is suitable as a biodegradable implant in the human body. Implant materials are used to prepare components, components or devices used in the diagnosis, treatment, and repair of living organisms, and are used to prepare artificial tissues and artificial organs that replace damaged tissues and organs of living organisms, etc., and have broad market application prospects .

Description

technical field [0001] The invention belongs to the field of magnesium-based amorphous alloy materials, and in particular relates to a fully absorbed Mg-Zn-Ag system amorphous medical implant substrate, a preparation method and application thereof. Background technique [0002] In modern biomedicine, some metals or alloys are often used as human implant materials, such as cardiovascular implant stents. The density and elastic modulus of magnesium and magnesium alloys are closer to those of human bone than other medical metal materials, and their mechanical properties are similar to those of human bones. As implant materials, they can effectively avoid or alleviate the force shielding effect and shorten the bone. tissue healing process. In addition, after being implanted into the human body, magnesium and magnesium alloys can be gradually absorbed and degraded by the human body with the recovery of the damaged tissue without the need for secondary surgery. tissue lesions. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C45/00B22F3/115A61L27/04A61L27/58A61L31/02A61L31/14
CPCC22C45/005B22F3/115A61L27/047A61L27/58A61L31/022A61L31/148C22C1/11
Inventor 王见张章赵玲玉都贝宁盛立远
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
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