Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition of 5-aminolevulinic acid and derivative thereof as well as application thereof

A technology of aminolevulinic acid and a composition, applied in the field of medicine, can solve problems such as poor treatment effect, decreased dosage, gel shedding, etc., so as to improve bioavailability, increase permeability, and improve patient discomfort. Effect

Active Publication Date: 2010-06-23
上海复旦张江生物医药股份有限公司
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, although the gel will adhere to the inner wall of the cavity according to the physiological structure of the administration site after entering, reducing the loss of ALA to a certain extent, it is still necessary to clean the cavity before administration, especially with the application. If the medicine time is prolonged, the large amount of mucus secreted by the cervix will easily cause the gel attached to the inner wall of the cavity to fall off, the actual application time will decrease, the dosage will decrease, and the treatment effect will be poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: (based on 1000 bottles)

[0029] Aminolevulinic acid hydrochloride 400g

[0030] Ethylparaben 0.9g

[0031] Edetate Disodium 7.5g

[0032] Povidone 30.0g

[0033] Pepsin 9.0g

[0034] Accurately weigh ethylparaben, povidone, and disodium edetate and put them in a 100ml beaker, add 100ml of 10% ethanol solution, stir to dissolve each auxiliary material, filter through a 0.8μm microporous membrane, and use the filtrate Small spray dryer (Buchi191 spray dryer, Switzerland) spray drying, spray drying conditions are as follows: inlet temperature: 140 ° C; outlet temperature: 86 ~ 94 ° C; vortex mixer: 80%; compressed air flow: 600 ~ 700 L / h ; Feed rate: 10%. Collect the powder in a collector.

[0035] Grind aminolevulinic acid hydrochloride through 80 mesh sieve, then mix with pepsin and the above powder, pass through 80 mesh sieve twice, add appropriate amount of ethanol solution, make soft material, granulate with 20 mesh sieve, and dry at 30°C with c...

Embodiment 2

[0038] Prescription: (based on 1000 bottles)

[0039] Aminolevulinic acid hydrochloride 100g

[0040] Pepsin 30.0g

[0041] Weigh 100g of aminolevulinic acid hydrochloride and pulverize it through an 80-mesh sieve, then mix it evenly with 30.0g of pepsin powder, pass through an 80-mesh sieve twice to obtain a powdery solid, and pack it separately.

[0042] When using, dissolve the powder in an appropriate amount of water and rub it on.

Embodiment 3

[0044] Prescription: (based on 1000 bottles)

[0045] Aminolevulinic acid hydrochloride 2000g

[0046] Pepsin 0.06g

[0047] Weigh 2000g of aminolevulinic acid hydrochloride and pulverize it through an 80-mesh sieve, then mix it evenly with 0.06g of pepsin powder, pass through an 80-mesh sieve twice to obtain a powdery solid, and pack it separately.

[0048] When using, dissolve the powder in an appropriate amount of water and rub it on.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of medicines, in particular relating to a composition of 5-aminolevulinic acid and a derivative thereof as well as application thereof. The composition of the 5-aminolevulinic acid and the derivative thereof disclosed in the invention comprises an effective dose of active constituent of the 5- aminolevulinic acid and the derivative thereof, and is characterized in that the composition also comprises proteolytic enzyme which is 0.035-277U per gram of the composition. The invention simultaneously discloses the application of the composition in the preparation of medicines for treating gynecological diseases. The composition can effectively improve the influence of cervical mucus on an active constituent ALA and a derivative thereof, enhances the permeability of the active constituent ALA and the derivative thereof in the cervical part, and improves the bioavailability of the ALA and the derivative thereof. The composition not only greatly improves the effect of the ALA and the derivative thereof on treating the gynecological diseases and in particular the cervical diseases, but also ameliorates the disamenity of the patients in the traditional treating process.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition of 5-aminolevulinic acid and its derivatives and its application. Background technique [0002] 5-Aminolevulinic acid (δ-aminolevulinic acid, ALA) and its derivatives are commonly used photodynamic therapy drugs, and the products already on the market include 5-aminolevulinic acid hydrochloride, 5-aminolevulinic acid methyl and hexyl 5-aminolevulinate. After entering the human body, it is transformed into hematoporphyrin (ProtorphyrinIX, PpIX) and stays in the body. After being illuminated by a specific wavelength, it will generate reactive oxygen species such as singlet oxygen and other free radicals and kill pathogenic cells (cancer cells, HPV and HSV infected cells) cells, wart cells), while adjacent normal tissue cells are not affected in any way. Clinically, 5-aminolevulinic acid (ALA) and its derivatives are used to treat acne, genital warts, actinic kerato...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/48A61K31/197A61K31/221A61K9/00A61K9/02A61K9/08A61K47/32A61K47/34A61K47/36A61K47/38A61P15/00A61P31/20A61P35/00A61K47/10
Inventor 曹峰苏勇陈文晖任晓岚
Owner 上海复旦张江生物医药股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com