26 results about "Immunological tests" patented technology

A detection method for detecting a substance to be detected in an immunological test sample, the detection method comprising a labeling step in which a complex of the substance to be detected and a labeling body is formed in the presence of at least one selected from imidazole and derivatives thereof, a pH buffer, and a polyvalent metal ion, the labeling body comprising a first probe molecule capable of binding to the substance to be detected and a label.

1. The name of this design product: Semi-automatic biochemical analyzer. 2. Purpose of the product of this design: used for quantitative analysis of clinical biochemical items and immunological tests of samples such as serum, plasma, urine, and cerebrospinal fluid. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The utility model relates to an immunological detection kit for mycoplasma pneumoniae in the technical field of immunological detection. The immunological detection kit comprises a main shell, an auxiliary shell is connected to the bottom of the main shell in an embedded mode. A clamping block is fixedly connected to the interior of the main shell; the clamping blocks are symmetrically arranged in the main shell; the supporting plate is placed through a buckling structure of the multiple clamping blocks. A sample pad is arranged at the top of the supporting plate; the sample pad is arranged between the main shell and the supporting plate; the top of the supporting plate is provided with a conjugate dilution pad; the conjugate dilution pad is arranged on one side of the sample pad; the top of the supporting plate is provided with an NC membrane, the NC membrane is arranged on one side of the conjugate dilution pad, the top of the supporting plate is provided with an absorption pad, and the absorption pad is arranged on one side of the NC membrane. And antibodies generated by mycoplasma pneumoniae infection and antibodies caused by other pathogen infection can be accurately distinguished.

The article related to this design is a specimen sensor device used in an electrochemical measuring instrument, and in particular, it is a disposable specimen sensor device used in immunological tests utilizing antigen-antibody reactions. This specimen sensor device is for detecting antigens and antibodies in body fluids, protein concentrations in food raw materials / processed products, and the like. This specimen sensor device includes a dropping port for dropping a solution containing a test substance, a viewing window through which the flow of the solution can be visually recognized, a ventilation port for confirming a wetness determination line and for ventilation, and an electrode connector substrate for insertion into an electrochemical measuring instrument.

The utility model discloses a test tube convenient for observing the agglutination degree of an immune test, which is applied to the technical field of medical instruments, ensures that the distribution of agglutinates at each angle can be stably observed through 360-degree dead-angle-free observation, keeps stable in rotation operation, avoids overturning of a sample, and is simple in structure and convenient to operate. The incident angle of ambient light can be adjusted to the optimal reflection range by the 45-degree inclination angle, so that the light forms a light and shade contrast enhancement effect on the surface of the agglutinant, the micro agglutination reaction is convenient to identify, and the projection of the agglutinant particles can be amplified to the optimal resolution size of human eyes; the top opening of the standard cylindrical tube body is smooth and round, the tube opening is thickened, the bottom transition is oblate, 20% of the upper surface of the outer surface of the tube body is frosted, and the remaining 80% of the outer surface of the tube body is transparent, so that the agglutination degree of an immune test can be observed more favorably; 20% of the upper surface of the tube body is frosted, so that the tube body is convenient to pick and is not easy to slip; liquid in the tube is not easy to pour out when the tube opening is thickened and inclined; and the pollution probability of the laboratory is reduced.

The invention relates to a blister packaging and protecting system developed to protect sensors, test kits and especially immunological test sensors from moisture and to prevent their degradation, to which a catalyst may be added in order to increase the sensitivity of said sensors.

Disclosed in the present invention is a monoclonal antibody binding to microtubule associated protein tau with 231Thr phosphorylation (pTau231). The present invention provides an amino acid sequence of a variable domain of the monoclonal antibody and an amino acid sequence of a complementarity determining region (CDR) comprised therein. The monoclonal antibody of the present invention has the ability to specifically recognize and significantly bind to the pTau231, and can be used as a reagent raw material for the development and production of pTau231 clinical in vitro diagnostic (IVD) medical device products based on the principle of immunological test.

The invention discloses an O-type foot and mouth disease virus multi-epitope virus-like particle nano antigen as well as a preparation method and application thereof. The nano antigen is obtained by sequentially connecting antigen epitopes of representative strains O / Tibet / CHA / 99, O / Mya98 / BY / 2010, OZK / 93, O / XJPS / CHA / 2017 and O / HKN / 2007 of three topological types of the O-type foot and mouth disease virus in series, introducing a T cell epitope of a foot and mouth disease virus 3A gene to a C terminal and finally inserting the T cell epitope into a cast mouse hepatitis B virus core antigen, and the amino acid sequence of the nano antigen is as shown in SEQ ID NO.6. An immunological test result shows that the nano antigen has good antigenicity, and a vaccine prepared from the nano antigen not only can induce generation of a high-level protective antibody, but also can protect immune animals from virus attack. In addition, the nano antigen has an immune protection effect on O-type foot-and-mouth diseases of pigs, cattle and sheep. The invention provides an effective technical means for preventing, controlling and purifying the foot-and-mouth disease.

In an electrochemical lateral flow immunological test method, flow of a sample solution is controlled. As a result, the reaction time is short and quantitative measurements and electrical measurements can be performed with excellent sensitivity and high accuracy, and the invention provides a sensor employed in the method. Electrode portions, electrically conductive portions for transferring electric current from the electrode portions, and connecting portions connected to an electrical measuring instrument for measuring the electric current values are arranged on a supporting body including a resin sheet, pads and the like disposed by partial lamination on the supporting body. A sample solution flows over the plurality of pads, and electrochemical detection is performed by controlling the flow at the position of the electrode portions. Furthermore, the flow is controlled by a flow rate control pad, a flow passage portion fiber pad, and flow rate control protruding portions.

The invention relates to the technical field of microbiological detection, in particular to a CRISPR / Cas12a-based detection kit and a CRISPR / Cas12a-based detection method for detecting bovine pasteurella multocida. An isothermal amplification primer pair is designed on the basis of a conserved kmt gene of bovine pasteurella multocida, the kmt gene is subjected to amplification marking by virtue of an isothermal amplification technology, and the detection kit for detecting bovine pasteurella multocida is constructed by virtue of the high-specificity recognition capability of CRISPR / Cas12a and the visualization advantage of an immune test strip. By utilizing the detection kit and the detection method provided by the invention, the bovine pasteurella multocida can be rapidly detected under normal-temperature and constant-temperature conditions, and the detection kit and the detection method have the advantages that the result is visual and accurate, the sensitivity is high, the operation steps are simple and convenient, and large precise instruments are not needed. The kit provided by the invention is suitable for various field detection scenes such as farms and grassroots veterinary stations, and an efficient tool is provided for early prevention and control of cattle pasteurellosis.

The article related to this design is a specimen sensor device used in an electrochemical measuring instrument, and in particular, a disposable specimen sensor device used in immunological tests utilizing antigen-antibody reactions. This specimen sensor device is for detecting antigens and antibodies in body fluids, protein concentrations in food raw materials / processed products, etc. This specimen sensor device is provided with a dropping port for dropping a solution containing a test substance, a viewing window through which the flow of the solution can be visually recognized, a ventilation port for confirming a wetness determination line and for ventilation, and an electrode connector substrate for insertion into an electrochemical measuring instrument.

The utility model discloses an immunoassay microwell plate sample adding auxiliary device which comprises a bottom plate, a placing groove is formed in the middle of the upper surface of the bottom plate, a microwell plate is placed in the placing groove, two supports which are distributed oppositely are arranged at the left end of the upper surface of the bottom plate, a cover plate is rotationally connected between the two supports through a rotating shaft, and the cover plate is connected with the bottom plate through a rotating shaft. The cover plate is positioned right above the micro-pore plate, and a plurality of sample adding holes which are distributed in one-to-one correspondence with the reaction holes in the micro-pore plate are formed in the surface of the cover plate. Through the arrangement of the light sensor and the indicator lamp, a worker can clearly know which holes are filled with an immunodetection reaction solution and which holes are not filled with the immunodetection reaction solution at a glance, so that the phenomena of missed adding and excessive adding can be effectively prevented, errors of detection data caused by excessive adding or missed adding are avoided, and the detection efficiency is improved. Therefore, the waste of resources and manpower is avoided, and the working efficiency is greatly improved.

The present application relates to a kind of anti-saxitoxin recombinant rabbit monoclonal antibody and its application, the amino acid sequence of the anti-saxitoxin recombinant rabbit monoclonal antibody includes heavy chain variable region and light chain variable region, respectively as shown in SEQ ID NO:1 And 10 shown in formula.The high sensitivity of it, the lowest saxitoxin can reach 7.3 pg mL ‑1 IC 50 , linear range is 0.0019 ng L ‑1 0.0282 ng L ‑1 ;Meanwhile, it also has high specificity, and other paralytic shellfish toxins and pufferfish toxin are not cross-reacted.The anti-saxitoxin recombinant rabbit monoclonal antibody prepared in the present application, compared with the anti-saxitoxin mouse monoclonal antibody on sale, the antibody provided in the present application is high in detection sensitivity, high in specificity, good in affinity, high in accuracy;It is suitable for immunological analysis kit, immunological test strip, immunoblotting and other clinical and scientific research applications.

1. Name of the Design Product: Immunoassay Chip. 2. Use of the Design Product: A test card. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective view of Design 1. 5. Design 1 is designated as the basic design.

1. Name of the Design Product: Immunoassay Test Card (1). 2. Use of the Design Product: This design product is an immunoassay test card. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph Most Indicating the Design Key Points: 3D view of Design 1. 5. Design 1 is designated as the basic design.

The invention provides a micro-fluidic immunoassay chip integrating lateral flow and vertical flow and an analysis method of the micro-fluidic immunoassay chip. Cooperative optimization of lateral flow immunoassay and vertical flow immunoassay is achieved through a self-driven micro-fluidic technology. According to the chip, the porous anodic aluminum oxide film is adopted to replace a test line in a lateral flow immune test strip, and a surface enhanced Raman scattering technology is combined, so that a target biomarker can be subjected to rapid, high-sensitivity and repeatable naked eye / Raman dual-readout detection. And the chip has the characteristics of being convenient to carry, simple and convenient to operate, low in cost, high in expansibility and the like, and has important significance on primary health care screening and field detection of public health emergencies.

The utility model relates to the field of immunological detection, in particular to a blood extraction device for immunological detection, which comprises a support frame, a first rotating rod mounted in the support frame, mounting frames arranged on the inner walls of two ends of the support frame, a bearing frame mounted on the first rotating rod, and a mounting seat arranged at the bottom of the bearing frame. Blood storage test tubes are inserted into the tops of the mounting seats; a fixing plate is installed on the outer wall of the supporting frame, a second driving part is installed on the fixing plate, a one-way screw rod is installed on the second driving part, a sliding block is connected to the one-way screw rod, a connecting plate is arranged on the sliding block, an extraction pipe is embedded in the connecting plate, a telescopic rod is embedded in the connecting plate, a connecting block is arranged at the top of the telescopic rod, and a connecting rod is arranged at the bottom of the connecting block; a piston plate is arranged at the bottom of the connecting rod, a sealing cavity and a liquid discharging assembly are formed in the piston plate, blood for immunological detection can be effectively, conveniently and automatically extracted and treated in sequence, and therefore the extraction device can be conveniently used.

This application relates to the field of data processing technology, and in particular to a method, system, device, medium, and product for generating rheumatoid and immunological test reports. The method includes receiving a VCF file from NGS sequencing, a report output directory, and a report output template to generate an order number; naming the VCF file, patient information file, quality control parameter file, and filter parameter file according to a naming convention including the order number, and saving them to the report output directory; extracting patient information, quality control parameters, filter thresholds, and a list of target rheumatoid and immunological diseases, and combining the paths of relevant files to generate, verify, and save a configuration file containing the order number to the report output directory; starting a Docker container to analyze the VCF file, and automatically filling the analysis results, patient information, and quality control parameters into the report output template, generating and saving a rheumatoid and immunological test report containing the order number to the report output directory, thus achieving fully automated generation and analysis from data input to result output.

The utility model belongs to immune inspection equipment technical field, and disclose a kind of immune inspection microplate sample adding auxiliary device, including auxiliary workbench, the top outer wall of auxiliary workbench is equipped with placing groove, the bottom inner wall center of placing groove is set to be placed positioning area, and the top of placing positioning area is placed with microplate, and the inner wall of auxiliary workbench is fixed with the ear plate of symmetry on the both sides of placing positioning area, the top outer wall of ear plate is inlayed and fixed with hydraulic rod, and the bottom end of hydraulic rod telescopic rod is fixed with the pressure holding seat, and the top outer wall of auxiliary workbench is provided with auxiliary positioning sample adding assembly;The utility model is provided with linkage splash-proof assembly, the pressure in front end cylinder before sample adding is increased, part liquid enters telescopic liquid bag by pressure relief pipe, so that it expands and pushes down cover ring, before liquid injection head extends into microhole, cover ring is first contacted with the surface of microplate and forms local seal, effectively prevent liquid splashing or aerosol formation when sample adding, reduce the risk of cross contamination between holes.

The utility model relates to the technical field of placing racks, in particular to a test tube placing rack for immunological examination. In order to solve the problems that along with operation, the action of a hand may accidentally knock down a placement rack, so that leakage of a sample is caused, and smooth inspection operation is affected, the following technical scheme is provided: the placement rack comprises a placement rack body, the placement rack body comprises two groups of symmetrically arranged side plates, a plurality of groups of first clamping plates are fixedly connected between the two groups of side plates, and a plurality of second clamping plates are fixedly connected between the two groups of side plates; a plurality of groups of first placing holes corresponding in position are formed in the plurality of groups of first clamping plates up and down, a group of second clamping plates are arranged below the plurality of groups of first clamping plates, the second clamping plates are fixedly connected between the two groups of side plates, and a plurality of groups of second placing holes are formed in the second clamping plates. After being placed on a table top, the placing rack can be fixed through simple operation, so that the placing stability of the placing rack body is ensured, a sample is prevented from being splashed, and the inspection operation is smoothly carried out.

The present disclosure provides improved methods of processing a fecal sample by a human subject in which the fecal sample is collected at home and subsequently delivered to a medical diagnostics laboratory. As described herein, the means of collecting and processing the fecal sample can desirably reduce the number of steps undertaken by the human subject, including avoiding steps of removing or separating the fecal sample into multiple portions. Furthermore, the human subject does not have to perform an immunological test (e.g., a fecal immunochemical test (FIT) or an immunochemical fecal occult blood test (iFOBT)) at home.

This invention discloses a Mycoplasma pneumoniae antibody detection kit based on immunoturbidimetry, belonging to the field of clinical immunology testing. It includes solutions R1 and R2. Solution R1 is a dispersion of double-coupled latex microspheres coated with natural Mycoplasma pneumoniae antigens, and solution R2 is a sample diluent containing an enhancer. The test samples can be serum, plasma, or whole blood samples, and it is applicable to biochemical analyzers, protein analyzers, or combined blood cell and immunoturbidimetric analyzers. The kit prepared by this invention can be used on various instruments, has a wide range of detection targets, and can be coupled with other instruments to detect various clinically valuable blood indicators, further shortening the testing time. It solves the problems of poor accuracy, low efficiency, and limited application scenarios caused by the subjective interpretation of results, long processing time, and limited applicability of blood samples in existing technologies. It can effectively simplify the testing process and improve diagnostic efficiency.

The present disclosure provides improved methods of processing a fecal sample by a human subject in which the fecal sample is collected at home and subsequently delivered to a medical diagnostics laboratory. As described herein, the means of collecting and processing the fecal sample can desirably reduce the number of steps undertaken by the human subject, including avoiding steps of removing or separating the fecal sample into multiple portions. Furthermore, the human subject does not have to perform an immunological test (e.g., a fecal immunochemical test (FIT) or an immunochemical fecal occult blood test (iFOBT)) at home.

The present invention addresses the problem of providing an immunological testing method which is highly sensitive and in which false positives are unlikely to occur. This immunological testing method comprises: a concentration step in which a liquid that could contain an antigen is mixed with a highly water-absorbent polymer to concentrate the liquid that could contain an antigen and to obtain an antigen-concentrated liquid; and a detection step in which an antigen in the antigen-concentrated liquid is detected by using an antigen-antibody reaction. The content, in the antigen-concentrated liquid, of a polymer having a weight-average molecular weight of less than 1,000,000 is more than 0 mg / mL and less than 35 mg / mL.

The application provides an anti-hyoscine monoclonal antibody and application and product thereof, and relates to the technical field of biology.The application immunizes Balb / c mice with hyoscine, fuses mouse spleen cells with myeloma cells, obtains hybridoma cells with high specificity through specific high-throughput screening, obtains a large amount of mouse ascites through culture and re-immunization, and further obtains high-purity, high-sensitivity and high-specificity anti-hyoscine monoclonal antibodies through multi-step separation and purification, thereby providing raw materials required for developing an immunological test strip for detecting hyoscine.The anti-hyoscine monoclonal antibody anti-hyoscine-mab1 of the application can be used for immunological detection such as immunoblotting and immunofluorescence, and the obtained antibody has good specific binding capacity.