Poly-a-hydroxy acid modified CdTe quantum dot and preparation method thereof

A technology of quantum dots and hydroxy acids, which is applied in the field of modifying CdTe quantum dots with poly a-hydroxy acids, to achieve the effects of simple and convenient operation, good water solubility and stability, and excellent fluorescence properties

Inactive Publication Date: 2015-02-25
YUNNAN MINZU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the research, we found that simply controlling the structure of inorganic nanowires and modifying the surface of nanomaterials with organic small molecules has certain effects on improving the biocompatibility of nanowires and reducing toxicity, but it also has limitations.

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  • Poly-a-hydroxy acid modified CdTe quantum dot and preparation method thereof

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Embodiment 1

[0013] A preparation method of polylactic acid modified CdTe quantum dots, the operation steps are as follows:

[0014] (1) Prepare sodium hydride telluride NaHTe solution as tellurium source;

[0015] (2) In a 50mL single-necked flask, mix 30mg of cadmium chloride, 240mg of trisodium citrate and 60mg of mercaptoethanol, add 35mL of deionized water, and exhaust with argon;

[0016] (3) Quickly inject 3 mL of sodium telluride hydride NaHTe solution with a concentration of 0.02 mg / mL into the mixed solution described in step (2), heat and reflux at 70°C for 1 hour, add an appropriate amount of absolute ethanol, and centrifuge. Freeze-drying for 24 hours to obtain CdTe quantum dots modified with mercaptoethanol;

[0017] (4) Mix L-lactic oxyanhydride and mercaptoethanol-modified CdTe quantum dots at a ratio of 1:1, add 10 mL of chloroform, add 2.1 mg of 4-dimethylaminopyridine, and use the hydroxyl groups at the end of the CdTe quantum dots to make L- Lactic acid oxyanhydride w...

Embodiment 2

[0020] A preparation method of polylactic acid modified CdTe quantum dots, the operation steps are as follows:

[0021] (1) Prepare sodium hydride telluride NaHTe solution as tellurium source;

[0022] (2) In a 50mL single-necked flask, mix 30mg of cadmium chloride, 270mg of trisodium citrate and 60mg of mercaptoethanol, add 35mL of deionized water, and exhaust with argon;

[0023] (3) Rapidly inject 3 mL of sodium telluride hydride NaHTe solution with a concentration of 0.02 mg / mL into the mixed solution described in step (2), heat and reflux at 90°C for 1 hour, add appropriate excess ethanol, and centrifuge, Freeze-drying for 24 hours to obtain CdTe quantum dots modified with mercaptoethanol;

[0024] (4) Mix L-lactic acid oxyanhydride and CdTe quantum dots modified by mercaptoethanol at a ratio of 6:1, add 10 mL of chloroform, add 6 mg of 4-dimethylaminopyridine, and make use of the hydroxyl groups at the end of CdTe quantum dots to make L- Lactic acid oxyanhydride is rin...

Embodiment 3

[0027] A preparation method of polylactic acid modified CdTe quantum dots, the operation steps are as follows:

[0028] (1) Prepare sodium hydride telluride NaHTe solution as tellurium source;

[0029] (2) In a 50mL single-necked flask, mix 30mg of cadmium iodide, 270mg of trisodium citrate and 90mg of mercaptoethanol, add 35mL of deionized water, and exhaust with argon;

[0030] (3) Rapidly inject 3 mL of sodium telluride hydride NaHTe solution with a concentration of 0.02 mg / mL into the mixed solution described in step (2), heat and reflux at 80°C for 2 hours, add appropriate excess ethanol, and centrifuge. Freeze-drying for 24 hours to obtain CdTe quantum dots modified with mercaptoethanol;

[0031] (4) Mix L-lactic oxyanhydride and mercaptoethanol-modified CdTe quantum dots at a ratio of 8:1, add 15 mL of chloroform, add 13 mg of 4-dimethylaminopyridine, and make use of the terminal hydroxyl groups of CdTe quantum dots to make L- Lactic acid oxyanhydride is ring-opened a...

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Abstract

The invention discloses a preparation method of a poly-a-hydroxy acid modified CdTe quantum dot. The preparation method comprises the following steps: preparing a CdTe quantum dot with a mercaptoethanol modified surface by taking the mercaptoethanol as a ligand and adopting a water-phase method; generating a-hydroxy acid oxygen acid anhydride polymerization by adopting hydroxy contained in the surface of the CdTe quantum dot; and introducing poly-a-hydroxy acid, namely polylactic acid, polyglycolic acid, poly (mandelic acid) and the like, to the surface of the CdTe quantum dot so as to realize the polymer modification on the CdTe quantum dot. The poly-a-hydroxy acid modified CdTe quantum dot has the advantages of good hydrophilicity and stability, excellent fluorescence property, good biocompatibility and the like and can be widely applied to the field of biomedicine as a novel fluorescent nanoprobe.

Description

technical field [0001] The invention relates to a CdTe quantum dot modified by poly-alpha-hydroxy acid and a preparation method thereof, in particular to a method for modifying CdTe quantum dot by poly-alpha-hydroxy acid, which belongs to the field of nanometer materials. Background technique [0002] In recent years, 1D semiconducting nanomaterials, including nanorods, nanowires, and nanotubes, have received more and more attention due to their unique structures, optical properties, and electrical properties, which make them promising in many fields, such as : Biosensors, drug carriers, solar cells, cell imaging, etc. CdTe nanomaterials belong to II–VI compound semiconductor nanomaterials, which not only have excellent optical properties, such as high absorption coefficient and wide absorption range, but also have excellent carrier transport properties, so they can be used in the above fields (Luo et al. al, Fabrication and growth mechanism of zinc blende and wurtzite CdTe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/88C08G83/00
Inventor 袁明龙覃宇悦肖臻刘冬李宏利郭俊明
Owner YUNNAN MINZU UNIV
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