41 results about "Cough medicine" patented technology

The invention discloses a preparation method of dimethylmorphinan phosphate used as a cough medicine. The method comprises the following steps: removing L-mandelic acid from (S)-l-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-L-mandelate to obtain (S)-l-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline, performing methylation by using the (S)-l-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline chiral material as a raw material, and then performing cyclization reaction together with phosphoric acid under the conditions of heating and decompression to obtain (9S,13S,14S)-3,17-dimethylmorphinan monophosphate with three chiral centers, namely dimethylmorphinan phosphate; and desalting, rectifying, crystallizing, salifying, drying, and packaging to obtain the refined dimethylmorphinan phosphate product. The method has the characteristics of simple process, low cost, high yield, high product purity, short production cycle and the like, thereby being a synthetic route suitable for industrial mass production.

The invention relates to a formula of Chinese medicinal lotion powder and effervescent tablets for preventing cough and a preparation method thereof. In the formula of the Chinese medicinal lotion powder, the Chinese medicinal lotion powder comprises the following Chinese medicines by weight: 3,750 grams of great burdock achene, 6,250 grams of mulberry bark, 3,750 grams of platycodon root, 3,125 grams of loquat leaf and 3,125 grams of borneol; and the preparation method for the Chinese medicinal lotion powder comprises the following steps of: weighing the Chinese medicines in a weight ratio, crushing into 200-mesh powder, stirring uniformly, and packaging in a form of 20 grams/bag. In the formula of the effervescent tablets, the effervescent tablets comprise the following raw material medicaments by weight: 690 grams of great burdock achene, 1,110 grams of mulberry bark, 690 grams of platycodon root, 520 grams of loquat leaf and 520 grams of borneol and comprise the following auxiliary materials by weight: 650 grams of citric acid, 780 grams of sodium bicarbonate, 1,105 grams of starch, 260 grams of sodium carboxymethyl starch, 195 grams of hydroxy propyl cellulose and 195 grams of polyethylene glycol 6000, The reparation method for the effervescent tablets comprises the following steps of: (1) preparing extract powder; (2) dividing the extract fine powder into two parts, adding 650 grams of citric acid into one part of the fine powder, mixing uniformly, pelletizing, drying, granulating, adding 780 grams of sodium bicarbonate into the other part of the fine powder, mixing uniformly, pelletizing, drying, and granulating; and (3) adding 195 grams of hydroxy propyl cellulose and 195 grams of polyethylene glycol 6000 into the granules, mixing uniformly, and tabletting to form 1,000 tablets.

The invention relates to preparation of a Prunin derivative and application thereof in drugs for relieving a cough and reducing phlegm. The Prunin derivative is obtained by introducing glycosyl or aliphatic chains or an amine group or an ether group, and the water solubility, the dissolving-out speed and the bioavailability are significantly improved. The Prunin derivative has better cough relieving and phlegm reducing effects, the curative effects on various coughs and asthma caused by acute bronchitis, chronic bronchitis, colds and the like are significant, and no toxic or side effect exists; compared with traditional cough medicine Nin Jiom Pei Pa Koa, the curative effect is more significant, and the Prunin derivative is an ideal drug for relieving the cough and reducing the phlegm, andhas a wide market prospect. The formula is defined in the description.

The invention discloses a traditional Chinese medicine bath preparation for children's cough and a preparation method thereof. The traditional Chinese medicine bath preparation for children's cough comprises 8-11g of bellflower, 8-11g of nepeta, 8-11g of radish, 8-11g of poria cocos, and 5-8g of ephedra , Fangfeng 5-8g, Pinellia 5-8g, Tangerine Peel 5-8g, Licorice 5-8g, Radix 5-8g, Aster 5-8g, Perilla 5-8g, White Mustard Seed 5-8g, Almond 3-5g; The preparation method of the traditional Chinese medicine bath agent for infant cough of the present invention comprises the steps of grinding traditional Chinese medicine powder, packing into bags, decocting and the like. The traditional Chinese medicine bath preparation for infantile cough and the preparation method thereof of the present invention aim at symptoms such as cold phlegm and cough of children under the age of 14, and have the effects of clearing the lung and relieving asthma, relieving cough, drying dampness and resolving phlegm, and the like.

The invention belongs to the technical field of microbes and discloses staphylococcus albus powder. The staphylococcus albus powder is prepared by inoculating a wheat bran nutrient medium with a staphylococcus albus seed solution and performing fermentation and culture. The staphylococcus albus powder disclosed by the invention is prepared by adopting a special fermentation technique, has the advantage of low cost and can be applied to preparation of cough medicines.

The invention discloses an antihistamine and sleep promotion composition and soft capsules. The composition comprises the following components in percentage by weight: 5-45% of diphenhydramine hydrochloride, 30-90% of polyethylene glycol and 1-25% of polyalcohol. Each soft capsule comprises soft capsule rubber cover and content, wherein the content comprises the following components in percentage by weight: 5-45% of diphenhydramine hydrochloride, 30-90% of polyethylene glycol and 1-25% of polyalcohol; the soft capsule rubber cover comprises the following components in percentage by weight: 50-90% of gelatin, 5-70% of plasticizer, 5-15% of purified water and 0-0.5% of coloring agent. The invention aims at providing an antihistamine and sleep promotion composition which is simple in composition, stable and effective and fast in dissolution and absorption, and soft capsules containing the antihistamine and sleep promotion composition. The soft capsules disclosed by the invention are suitable for the allergy of the skin mucosa, prevention of motion sickness, Parkinson's disease and extrapyramidal symptoms for calming and hypnosis, enhance the effects of cough medicines, and are suitable for the cough caused by cold or allergy.

The invention discloses an itching, cough and asthma relieving lozenge and a preparation method thereof, which relate to an antitussive and a preparation method thereof, in particular to the itching, cough and asthma relieving lozenge and the preparation method thereof. The prior antitussives on the market itch throats and have no obvious therapeutic effect, and the invention is the novel antitussive which mainly relieves the itching of the throats, can relieve itching, can also relieve cough, and also has asthma-relieving effect when the antitussive is frequently taken. The lozenge takes seven Chinese medicines, namely shanxi aged vinegar, rock sugar, lepidium seed, radix cynanchi, Chinese ephedra, borneol, and fresh willow braches and leaves as main ingredients, and is produced by adding the medicines according to certain proportion; and two technical proposals are used: the first is a boiling type manufacturing method, and the second is a purification type manufacturing method. The two proposals are both adopted to prepare the seven Chinese medicines into the caked sugar shaped antitussive, and the antitussive has therapeutic effects of itching relieving, cough relieving and asthma relieving, particularly has instant therapeutic effect on the itching relieving, and can relive itching to achieve the cough relieving within tens of seconds after taken by people.

The invention discloses a lung-clearing cough-relieving drug comprising the following raw materials in parts by mass: 1-3 parts of medicated leaven, 2-4 parts of common scouring rush herb, 2-5 parts of rhizoma cimicifugae, 1-4 parts of dragon bone, 2-3 parts of antifeverile dichroa root, 1-3 parts of obscured homalomena rhizome, 2-5 parts of nux vomica, 3-8 parts of loquat leaf, 2-6 parts of medicinal evodia fruit and 3-7 parts of ophiopogon root. The lung-clearing cough-relieving drug disclosed by the invention has the efficacies of clearing lung and relieving cough, dissipating heat and stopping pain, calming the adverse-rising energy and stopping vomit, invigorating spleen and promoting digestion, regulating vital energy and dissipating dampness, dispelling wind and heat, improving eyesight and removing nebula, relieving convulsion and soothing nerves, arresting sweating and spontaneous emission, stop bleeding and astringing intestines, promoting tissue regeneration and healing sore.

The invention provides a lung-heat cough medicine, and belongs to the field of traditional Chinese medicine. The lung-heat cough medicine includes the following raw materials: Chinese arborvitae leaf, radix bupleuri, fresh bamboo sap, day lily, honeysuckle, rhizoma pinellinae praeparata, stem and leaf of briar, broussonetia kaempferi, piper sarmentosum, longhairy antenoron herb, radix puerariae, abrus cantoniensis hance, common clubmoss herb, imperata rhizome, herba rabdosiae, honeysuckle stem, edible vinegar, and pork ribs. The invention also discloses a preparation method of the medicine. The raw materials are all natural medicines and have no drug resistance, no residue and no side effects; in addition, based on Chinese arborvitae leaf having good treatment of lung-heat cough and broussonetia kaempferi having good treatment of cough, the added radix bupleuri, fresh bamboo sap, day lily, honeysuckle, rhizoma pinellinae praeparata, stem and leaf of briar, piper sarmentosum, longhairy antenoron herb, radix puerariae, abrus cantoniensis hance, common clubmoss herb, imperata rhizome, herba rabdosiae and honeysuckle stem can have good interaction and have obvious effect on treatment of lung-heat cough; based on a pork rib soup, a patient can well absorb the medicine; and in addition, with addition of the edible vinegar, the traditional Chinese medicine taste can be effectively removed.

The invention relates to preparation of low-glycosylation prunin and application in a cough relieving and sputum reducing medicine. Low-glycosylation prunin is prepared by conducting two times of bioenzyme catalysis on raw materials such as naringin. Through the two times of bioenzyme catalysis, the problem of poor water solubility and lipid solubility of prunin is solved, the solubility of pruninis increased by 75 folds or above through low glycosylation, the bioavailability is increased obviously, and prunin can be applied widely. Low-glycosylation prunin has a better cough relieving and sputum reducing effect and has an obvious efficacy on all kinds of cough and asthma caused by acute/chronic bronchitis or cold, there is no toxic and side effect, the efficacy of low-glycosylation prunin is more obvious than that of a traditional cough relieving medicine-(Nianci) Chuanbei Pipa Gao, and low-glycosylation prunin is an ideal cough relieving and sputum reducing medicine and has a wide market prospect. The chemical structural formula of low-glycosylation prunin is shown in the description.

The invention discloses a cough-relieving medicine formula. The cough-relieving medicine formula is prepared from the following raw materials in parts by mass: 9-45 parts of ramulus cinnamomi, 9-45 parts of radix paeoniae alba, 10-50 parts of semen armeniacae, 9-45 parts of rhizoma cynanchi stauntonii, 9-45 parts of radix platycodonis, 9-45 parts of radix asteris, 9-45 parts of flos farfarae, 15-75 parts of radix adenophorae, 15-75 parts of bulbus lilii, 5-25 parts of fructus schisandrae and 5-25 parts of bulbus fritillariae. The invention relates to the technical field of cough-relieving medicine formulas. The cough-relieving medicine formula has remarkable curative effects on various coughs such as dry cough, productive cough, lung heat cough, lung yin deficiency cough, cough after cold,aged cough, cough regardless of day and night, cough while speaking, cough in cold and cough in smoking; a cough-relieving medicine can also be prepared into decoction, granules, capsules and the like; and honey exists in pills and has the effects of clearing heat, tonifying middle warmer, moistening dryness, improving immunity and the like, so that the pills have the best effect.

The invention discloses a traditional Chinese medicine for relieving cough, which is prepared from the following raw materials: 2-8 parts of Taizishen, 4-10 parts of fig, 5-10 parts of Platycodon grandiflorum, 4-8 parts of saxifrage, 2-8 parts of Tinglizi ‑7 parts, 15-20 parts of mint, 15-25 parts of raw land, 5-20 parts of Fritillaria, 5-8 parts of Luo Han Guo, 1-10 parts of Bai Bu, 1-10 parts of Lucky Herb, 4-6 parts of licorice, 10-12 servings of Poria, 4-10 servings of wolfberry fruit, and 3-10 servings of ginseng. The beneficial effects of the present invention are as follows: the present invention has the characteristics of good curative effect, short time, small dosage, low cost, environmental protection, convenient drinking, easy absorption of traditional Chinese medicine ingredients, and obvious effect. It has the characteristics of moistening the lungs and relieving cough, and has good therapeutic effect. It can be used to treat cough and dry throat caused by colds and acute and chronic bronchitis.

The present invention relates to a cough medicine formula. The raw materials in the formula are composed of 5-15% of mint, 1-5% of tangerine peel, 1-10% of Baibu, 5-15% of Bupleurum and 3% of bitter almond. ‑9%, Bellflower 2‑3%, Carrot 1‑5%, Forsythia 11‑19%, Ginger 5‑7%, Citrus aurantium 3‑5%, Licorice 3‑5%, Honeysuckle 3‑5%, Purple Perilla 5-10%, Jujube 1-1.5%, Pibaye 4-5%, Angelica dahurica 2-4%, Guizhi 0.4-0.6%, Zhilicorice 1-2%, Aconitum 2-4%, The cough medicine of the present invention has the effect of stably lowering blood pressure without rebounding, long-term stable blood pressure, no need for long-term medication, no drug resistance, safety and no side effects, suitable for a wide range of people, and is a caring medicine for ordinary people.

The invention provides a cough medicine composition. The raw materials of the cough medicine composition comprises, by weight, 3-10 parts of ephedra stir-frying with honey, 5-10 parts of semen armeniacae amarum, 12-17 parts of gypsum, 2-7 parts of radix glycyrrhizae, 2-7 parts of acorus calamus, 1-4 part of herba epimedii, 1-5 parts of chinese honeylocust abnormal fruit, 15-25 parts of talc, 7-13 parts of rhizoma anemarrhenae, 20-40 parts of fructus hordei germinatus and 5-10 parts of radix angelicae. The cough medicine composition is precise and appropriate in compatibility of medicinal materials and can be used for treating mucousy, especially lung heat cough or lung heat cough and common cold due to cold-wind; and in addition, while ephedra villus is used, the cough medicine composition is especially suitable for treating child cough and provides a new choice for clinical medication.

The invention relates to a method of treating cough and a cough medicine prepared by the method. The method is mainly characterized by comprising the following steps: 1) adding 2000g of water into seven medicinal materials including 50g of cortex mori radicis, 10g of cortex lycii radicis, 5g of liquorice, 10g of bamboo juice, 40g of specious alpinia seeds, 50g of greater pteris and 35g of large-leaved cayratia to be decocted for 2 hours; jointly decocting twice; combining the decoction liquids; filtering; concentrating to 500ml; adding 3.5g of sodium benzoate; stirring till sodium benzoate is dissolved; adding 50g of rock candy; continuously heating to boil by slow fire; insulating for 1 hour; and uniformly mixing to obtain the medicine. The medicine provided by the invention has the beneficial effects of clearing heat, promoting diuresis, dispelling wind, detoxifying, relieving cough and eliminating phlegm.

Belonging to the field of cough-relieving drugs, the invention in particular relates to a cough-relieving medicinal liquor. The cough-relieving medicinal liquor is prepared from the following raw materials by weight: 3-4 parts of loquat leaf, 5-10 parts of white radish seeds, 3-10 parts of Bulbus fritillariae cirrhosae, 3-8 parts of lily, 3-7 parts of perilla, 1-2 partse of wrinkled gianthyssop herb, 2-5 parts of ginkgo, 3-7 parts of platycodon grandiflorus, 3-7 parts of reed root, 1-3 parts of folium mori, and 50-80 parts of liquor. The raw materials selected by the invention are all picked naturally, the cough-relieving medicinal liquor has the effects of regulating qi and clearing lung, relieving cough and reducing sputum, has excellent curative effect on pharyngitis, dry, itching and aching throat, and acute and chronic bronchitis, etc., and is especially effective for curing intractable cough.

The invention relates to a cough medicine formula. The formula comprises the following raw materials in parts by weight: 2-10 parts of liquorice root, 6-14 parts of mint, 4-10 parts of bulbus fritillariae cirrhosae, 6-14 parts of radix puerariae, 3-13 parts of fructus forsythia, 4-16 parts of radix bupleuri, 2-6 parts of radix platycodonis, 2-8 parts of herba rabdosiae, 5-13 parts of reed rhizome,3-7 parts of loquat leaves, 1-3 parts of ginger, 2-6 parts of herba abri, 4-10 parts of radix scutellariae, 2-6 parts of dried orange peel, 5-15 parts of herba lysimachiae, 2-6 parts of cassia twigs,2-10 parts of semen armeniacae amarae, 1-3 parts of radix angelicae dahuricae, and 10-20 parts of fresh bamboo juice. The raw materials of the cough medicine prepared according to the formula are pure traditional Chinese medicines, so that the cough medicine has small side effects on a human body, has the effects of promoting the secretion of saliva or body fluid and quenching thirst, clearing away the lung-heat and relieving sore throat and detoxifying and abating fever, fundamentally improves the symptoms of throat dryness, itching and swelling and pain, and has a very good treatment effecton cough.

The invention belongs to the field of traditional Chinese medicine preparations, and the purpose is to provide a pill medicine for clearing the lungs, resolving phlegm, relieving cough and relieving asthma according to the cognitive mechanism of traditional Chinese medicine for treating cough and asthma. The components and their mass ratios of the medicine are as follows : Ephedra 25~120g, Anemarrhena 60~150g, Scrophularia 90~160g, Poppy shell 50~120g, Baiqian 30~120g, Ophiopogon japonicus 60~150g, Coltsfoot flower 30~100g, Aster 30~180g, Radix 50g ~100g, almond 50~90g, centipeda 30~100g, dannanxing 50~120g, fritillary fritillary 30~120g, Tinglizi 30~100g; the medicine provided by the invention is a good traditional Chinese medicine prescription.