A kind of rapid granulation method of traditional Chinese medicine spray extract cough tablet

A technology of traditional Chinese medicine and extract, applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of double time, inflammable and explosive, high pollution probability, etc. Simple, uniform heating, low contamination rate

Active Publication Date: 2015-09-23
丰宁满族自治县七环旅游开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this preparation method are: long operating procedures, poor continuity, high probability of contamination, especially hundreds of kilograms of wet particles, placed on hundreds of stainless steel trays, which are concentrated in high-concentration ethanol in the workshop, which not only has the potential to easily The danger of flammability and explosion is also affected by the temperature and humidity of the workshop. If the humidity exceeds 50% and the temperature exceeds 25°C, hundreds of kilograms of wet granules are not stirred in time, and it is easy to absorb moisture and become syrupy, resulting in Granulation failure
It must be dried and re-granulated, the ingredients are lost, and the time is doubled
Under smooth conditions, 3-5 operators are needed to complete the preparation of more than 100 kilograms of granules in one day

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh the spray-dried powder of more than 200 times the prescription amount, weigh the corresponding medicinal starch with the dry powder-medicinal starch in a weight ratio of 3:1, put it in a V-type mixer, mix evenly, and set aside;

[0031] (2) Prepare a 50% ethanol solution with 2.3g: 1mL of the spare mixed powder weight-50% ethanol solution volume, and then add povidone according to the volume of the prepared ethanol solution at a ratio of 2g povidone K30 per 100mL After K30, stir, dissolve, and mix evenly, and move it into the spray storage tank as a granulation binder;

[0032] (3) Move the mixed powder under item (1) into the granulator that has been preheated to 50-60°C by means of vacuum suction;

[0033] (4) Turn on the spray knob connected to the spray storage tank, spray the adhesive at 50-60°C, form granules while blasting and drying, observe and check from the observation window of the granulator and the micro-feeding port from time to time When the d...

Embodiment 2

[0036] (1) Weigh the spray-dried powder that is more than 200 times the prescription amount, weigh the corresponding medicinal starch with a weight ratio of 4:1 dry powder-medicinal starch, put it in a V-type mixer, mix evenly, and set aside;

[0037] (2) Prepare a 50% ethanol solution with 2.4g: 1mL of the standby mixed powder weight-50% ethanol solution volume, and then add povidone according to the volume of the prepared ethanol solution at a ratio of 2g povidone K30 per 100mL After K30, stir, dissolve, and mix evenly, and move it into the spray storage tank as a granulation binder;

[0038] (3) Move the mixed powder under item (1) into the granulator that has been preheated to 50-60°C by means of vacuum suction;

[0039] (4) Open the spray knob connected to the spray storage tank, spray the adhesive at 50-60°C, form granules while blowing and drying, observe and check from the observation window of the granulator and the micro-feeding port from time to time When the drug ...

Embodiment 3

[0042] (1) Weigh the spray-dried powder that is more than 200 times the prescription amount, weigh the corresponding medicinal starch with the dry powder-medicinal starch in a weight ratio of 5:1, put it in a V-shaped mixer, mix it evenly, and set aside;

[0043] (2) Prepare a 50% ethanol solution with 2.5g: 1mL of the standby mixed powder weight-50% ethanol solution volume, and then add povidone according to the volume of the prepared ethanol solution at a ratio of 2g povidone K30 per 100mL After K30, stir, dissolve, and mix evenly, and move it into the spray storage tank as a granulation binder;

[0044] (3) Move the mixed powder under item (1) into the granulator that has been preheated to 50-60°C by means of vacuum suction;

[0045] (4) Open the spray knob connected to the spray storage tank, spray the adhesive at 50-60°C, form granules while blowing and drying, observe and check from the observation window of the granulator and the micro-feeding port from time to time Wh...

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PUM

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Abstract

The invention relates to a method for quickly granulating traditional Chinese medicinal spray-extract anti-cough tablets. The method is characterized by comprising the following steps of: uniformly mixing starch and spray powder which are different in mass percent by using a V-type mixer on the basis of wet granulation; blowing to suspend medicinal powder at a specified temperature and spraying a granulation wetting agent at the same time, wherein the medicinal powder comes into contact with the atomized wetting agent to form granules; drying the granules with hot air; repeating the steps of suspension, granulation and drying again and again until the medicinal powder is completely formed into granules and the granules reach the specified moisture content. The method is simple and quick; soft material preparation, granulation and drying are all completed in the same equipment, and 110kg of granules can be made in 70 minutes, the efficiency is 4-5 times that of a traditional method, materials are heated uniformly, the preparation time is short, and the granule pollution rate in the preparation process is low. Furthermore, the yield of the granules is not limited by the amount of starch, and qualified granules can be obtained according to the proportion in the method provided by the invention.

Description

technical field [0001] The invention relates to a rapid granulation method for cough-relieving tablets of traditional Chinese medicine spray extract. Background technique [0002] The granulation methods commonly used in traditional Chinese medicine include: wet granulation, dry plate-making, spray granulation, etc. The appropriate granulation method can be selected according to the composition of the prescription, the preparation process and the characteristics of the required granules. [0003] Dry granulation is mostly the granulation of the whole extract of traditional Chinese medicine, and most of them are the granulation of the whole spray extract with large prescription dosage and no auxiliary materials. The spray-dried fine powder is directly dry-pressed into tablets by using special pressing equipment, and then Break the flakes into small particles. Although this method is simple, it must be equipped with special equipment, and the granules made by the dry method a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K9/20A61K9/16A61K47/36A61K47/32A61P11/14A61J3/02
Inventor 韩桂茹吴云贺张文臣宋长国张文武申玉龙
Owner 丰宁满族自治县七环旅游开发有限公司
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